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Hybridomas --- Monoclonal antibodies --- Antibodies, Monoclonal --- Hybridomas. --- Monoclonal antibodies. --- Monoclonal immunoglobulins --- Myeloma-spleen cell hybrids --- Biotechnology. --- Immunology. --- Medical Technology. --- Immunoglobulins --- Molecular cloning --- Clone cells --- Lymphocytes --- Plasmacytoma --- Somatic hybrids --- Agriculture Sciences --- Engineering --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Biotechnology

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Georges Köhler (1946-1995) was one of the most prominent German scientists of recent history. In 1984, at an age of 38, he received the Nobel Prize in Physiology or Medicine, together with N.K. Jerne and C. Milstein, for inventing the technique for generating monoclonal antibodies. This method and its subsequent applications had an enormous impact on basic research, medicine and the biotech industry. In the same year, Köhler became one of the directors of the Max-Planck-Institute of Immunobiology in Freiburg; his unfortunate premature death in 1995 set an end to his extraordinary career. Prof. Klaus Eichmann, who had joined the institute as director in 1981, and had invited Köhler to become his codirector, is one of the people who were closest to Georges Köhler. This scientific biography commemorates the 10th anniversary of Köhler's untimely death. It describes his scientific and personal biography, based on 10 years of close personal and professional relationship between Eichmann and Köhler, as well as interviews with many colleagues and friends, including his "Doktorvater" and mentor Fritz Melchers. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of the immunological research at the time.

Immunologists --- Hybridomas. --- Monoclonal antibodies. --- Köhler, Georges. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Myeloma-spleen cell hybrids --- Clone cells --- Lymphocytes --- Monoclonal antibodies --- Plasmacytoma --- Somatic hybrids --- Immunology --- Medical scientists --- Immunology. --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Immunobiology --- Serology --- Health Workforce --- Biomedicine, general. --- Köhler, Georges --- Kohler, Georges.

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Immunopharmacology --- Immunotoxicology --- Allergy and Immunology --- Immune System --- Pharmacology --- drug effects --- Immunotoxins --- Communicable Diseases --- Immunopharmacology. --- Immunotoxicology. --- Immunology. --- Pharmacology. --- Toxicology. --- Immunotoxins. --- Allergy and Immunology. --- Communicable Diseases. --- Immunologic toxicology --- Immunotoxicity --- Pharmacoimmunology --- Infectious Diseases --- Communicable Disease --- Disease, Communicable --- Disease, Infectious --- Diseases, Communicable --- Diseases, Infectious --- Infectious Disease --- Pharmacologies --- Pharmaceutical Preparations --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- Affinotoxins --- Chimeric Toxin --- Immunotoxin --- Monoclonal Antibody-Toxin Conjugates --- Toxin Carrier --- Toxin Conjugate --- Antibody-Toxin Conjugates --- Antibody-Toxin Hybrids --- Chimeric Toxins --- Cytotoxin-Antibody Conjugates --- Targeted Toxins --- Toxin Carriers --- Toxin Conjugates --- Toxin-Antibody Conjugates --- Toxin-Antibody Hybrids --- Toxins, Chimeric --- Toxins, Targeted --- Antibody Toxin Conjugates --- Antibody Toxin Hybrids --- Antibody-Toxin Conjugates, Monoclonal --- Carrier, Toxin --- Carriers, Toxin --- Conjugate, Toxin --- Conjugates, Antibody-Toxin --- Conjugates, Cytotoxin-Antibody --- Conjugates, Monoclonal Antibody-Toxin --- Conjugates, Toxin --- Conjugates, Toxin-Antibody --- Cytotoxin Antibody Conjugates --- Hybrids, Antibody-Toxin --- Hybrids, Toxin-Antibody --- Monoclonal Antibody Toxin Conjugates --- Toxin Antibody Conjugates --- Toxin Antibody Hybrids --- Toxin, Chimeric --- pharmacology --- Immunopathology --- Toxicology --- Disease Outbreaks --- Disease Transmission, Infectious --- Recombinant Fusion Proteins --- Antibodies, Bispecific --- Affinotoxin --- Antibody-Toxin Conjugate --- Antibody-Toxin Hybrid --- Cytotoxin-Antibody Conjugate --- Monoclonal Antibody-Toxin Conjugate --- Targeted Toxin --- Toxin-Antibody Conjugate --- Toxin-Antibody Hybrid --- Antibody Toxin Conjugate --- Antibody Toxin Hybrid --- Antibody-Toxin Conjugate, Monoclonal --- Conjugate, Antibody-Toxin --- Conjugate, Cytotoxin-Antibody --- Conjugate, Monoclonal Antibody-Toxin --- Conjugate, Toxin-Antibody --- Cytotoxin Antibody Conjugate --- Hybrid, Antibody-Toxin --- Hybrid, Toxin-Antibody --- Monoclonal Antibody Toxin Conjugate --- Toxin Antibody Conjugate --- Toxin Antibody Hybrid --- Toxin, Targeted

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This book, a collection of 12 original contributions and 4 reviews, provides a selection of the most recent advances in the preparation, characterization, and applications of polymeric nanocomposites comprising nanoparticles. The concept of nanoparticle-reinforced polymers came about three decades ago, following the outstanding discovery of fullerenes and carbon nanotubes. One of the main ideas behind this approach is to improve the matrix mechanical performance. The nanoparticles exhibit higher specific surface area, surface energy, and density compared to microparticles and, hence, lower nanofiller concentrations are needed to attain properties comparable to, or even better than, those obtained by conventional microfiller loadings, which facilitates processing and minimizes the increase in composite weight. The addition of nanoparticles into different polymer matrices opens up an important research area in the field of composite materials. Moreover, many different types of inorganic nanoparticles, such as quantum dots, metal oxides, and ceramic and metallic nanoparticles, have been incorporated into polymers for their application in a wide range of fields, ranging from medicine to photovoltaics, packaging, and structural applications.

graphene oxide --- n/a --- latex compounding method --- gold nanoparticles --- ratiometric temperature sensing --- catalysis --- conjugated polymer nanoparticles --- carrier transport --- polymer-NP interface --- nanocomposites --- polyethylene --- structure-property relationship --- chemical and physical interface --- SiO2/TiO2 nanocomposite --- nanoparticles --- separation --- conductive polymer --- clays --- organic light-emitting diodes (OLEDs) --- nanocomposite --- molecular chain motion --- nanosheets --- morphology --- metal oxides --- hybrid hydrogels --- gas barrier properties --- nanomaterials --- in situ synthesis --- mechanical properties --- power cable insulation --- inorganic nanotubes --- surface modification of silica --- optoelectronic properties --- layered structures --- sol–gel --- nano-hybrids --- fluorescent assay --- N-isopropylacrylamide --- bismaleimide --- electrical property --- solar cell --- N-isopropylmethacrylamide --- SiO2 microspheres --- PFO/MEH-PPV hybrids --- power-conversion efficiency --- in-situ synthesis --- electrical breakdown --- active layer --- crystallization kinetics --- polypropylene nanocomposite --- electric energy storage --- silver ions --- composite membrane --- carbon nanoparticles --- graphene --- composites --- electrode --- reduced graphene oxide --- selective adsorption --- thermoresponsive hyperbranched polymer --- colorimetric sensor --- FRET --- polymers --- graphene-like WS2 --- polymer-matrix composites --- thermoplastic nanocomposite --- fluorescence resonance energy transfer --- PHBV --- melamine --- Ag nanoparticles --- adhesion --- chain topology --- interfacial layer --- silica/NR composite --- sol-gel

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Surface-enhanced Raman scattering (SERS) is a research technique that was discovered in the mid-1970s. SERS is a powerful and fast tool for analysis, which has a high detection sensitivity for a great number of chemical and biological molecules. However, it is in this last decade that a very significant explosion of the fabrication of highly sensitive SERS substrates has occurred using novel designs of plasmonic nanostructures and novel fabrication techniques of the latter, as well as new plasmonic materials and hybrid nanomaterials. Thus, this Special Issue is dedicated to reporting on the latest advances in novel plasmonic nanomaterials that are applied to the SERS domain. These developments are illustrated through several articles and reviews written by researchers in this field from around the world.

pulsed laser ablation --- acetonitrile (CH3CN) --- Cu/gCN hybrids --- localized surface plasmon resonance (LSPR) --- surface enhanced Raman scattering (SERS) --- surface enhanced resonance Raman scattering (SERRS) --- silver aggregates --- laser-induced synthesis --- surface-enhanced Raman scattering --- hot spots --- SERS --- sensors --- plasmonics --- gold --- silicon --- surface-enhanced Raman scattering (SERS) --- surface plasmon polariton (SPP) --- surface plasmon resonance (SPR) --- nanograting --- nanofabrication --- electron beam lithography --- zinc oxide --- metal oxides --- self-assembly --- bimetallic nanoparticles --- localized surface plasmon --- surface enhanced Raman scattering --- grating effect --- gold nanodisks --- Rayleigh anomaly --- n/a