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There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Moreover, recent observations of community acquired infections have been reported, especially in patients with various risk factors such as immuno-deficiencies. Also, it is now becoming evident that Acinetobacter infections occur frequently in violent situations such as earthquake or war zones. The mechanisms of Acinetobacter virulence are becoming increasingly clear, providing new insights into their pathogenic role in community acquired infections. It is apparent the time is appropriate for detailed review of the increasing knowledge concerning important new information, both clinical and therapeutic, especially information concerning virulence, resistance mechanisms and typing of Acinetobacter spp. Many new findings are accumulating in almost an exponential manner since publication of previous books on this subject in 1991 and 1996.

Life Sciences. --- Microbiology. --- Immunology. --- Virology. --- Life sciences. --- Medical virology. --- Sciences de la vie --- Immunologie --- Virologie médicale --- Microbiologie --- Acinetobacter infections. --- Acinetobacter. --- Nosocomial infections. --- Acinetobacter infections --- Acinetobacter --- Nosocomial infections --- Moraxellaceae Infections --- Biology --- Moraxellaceae --- Infection --- Anti-Infective Agents --- Therapeutic Uses --- Gram-Negative Aerobic Rods and Cocci --- Gram-Negative Bacterial Infections --- Bacterial Infections and Mycoses --- Biological Science Disciplines --- Gammaproteobacteria --- Gram-Negative Aerobic Bacteria --- Bacterial Infections --- Natural Science Disciplines --- Diseases --- Proteobacteria --- Pharmacologic Actions --- Disciplines and Occupations --- Bacteria --- Gram-Negative Bacteria --- Chemical Actions and Uses --- Chemicals and Drugs --- Organisms --- Acinetobacter Infections --- Microbiology --- Anti-Bacterial Agents --- Cross Infection --- Health & Biological Sciences --- Microbiology & Immunology --- Hospital-acquired infections --- Hospital infections --- Acinetobacter diseases --- Colloides --- Herella --- Mimae --- Iatrogenic diseases --- Gram-negative bacterial infections --- Neisseriaceae

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Clinical Blood Pool MR Imaging »This excellent treatise on Vasovist® created by a team of exceptional faculty who are pioneers in MR Angiography covers the basic techniques, safety, efficacy, image processing and pharmaco-economic details to successfully implement a new level of MRA image quality with this new contrast agent.« Martin Prince, Cornell University, New York »The editors and authors have made groundbreaking contributions towards establishing MR angiography in various investigative settings, rendering it more precise and applying it for diverse indications. The work presented here is founded upon the extensive experience of the editors, as well as the broad range of experience from other scientific working groups.« Maximilian Reiser, Ludwig Maximilian University, Munich Vasovist® (Gadofosveset), worldwide the first blood pool agent, has only recently become available for clinical use, but has already gained wide acceptance as a tool to improve magnetic resonance angiography. This book presents the first in-depth introduction to the basic physicochemical aspects of the agent, the application of Vasovist® in clinical MRA, as well as potential clinical applications beyond MRA and patient management-related aspects. The first part of the book explains basic and technical properties of the agent and the differences of Vasovist® compared to currently available extracellular agents. The second part contains detailed chapters on safety and efficacy. In the third part the focus is on MR angiographic applications, and in the fourth part of the book potential clinical fields beyond MRA are explored. All clinical chapters feature ready-to-use clinical protocols and a series of take home messages that concisely summarize the current role of blood pool imaging for each specific indication.

Medicine & Public Health. --- Imaging / Radiology. --- Medicine. --- Medical radiology --- Médecine --- Radiologie médicale --- Angiography. --- Contrast media (Diagnostic imaging). --- Gadolinium -- Diagnostic use. --- Gadolinium --- Magnetic Resonance Angiography --- Contrast Media --- Lanthanoid Series Elements --- Magnetic Resonance Imaging --- Specialty Uses of Chemicals --- Angiography --- Metals, Rare Earth --- Diagnostic Imaging --- Tomography --- Chemical Actions and Uses --- Diagnostic Techniques, Cardiovascular --- Elements --- Diagnostic Techniques and Procedures --- Inorganic Chemicals --- Metals --- Chemicals and Drugs --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Radiology, MRI, Ultrasonography & Medical Physics --- Cardiovascular Diseases --- Medicine --- Health & Biological Sciences --- Blood-vessels --- Magnetic resonance imaging. --- Diseases --- Diagnosis. --- Angiology --- Vascular system --- Vasculature --- Radiology. --- Cardiovascular system --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological physics --- Physics --- Radiation

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Clinical interest in the camptothecins continues to expand even though this class of topoisomerase I inhibitors has been studied for almost 50 years, and two early generation members of the family have gained FDA approval. In Camptothecins in Cancer Therapy, leading clinicians and researchers critically review our current understanding of camptothecins, their shortcomings, and the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance. Authoritative and up-to-date, Camptothecins in Cancer Therapy provides a comprehensive summary of camptothecin research, as well as a much-needed guide to all the latest information on their optimal therapeutic applications.

Camptothecin --- Neoplasms --- Antineoplastic Agents, Phytogenic --- Camptothecin. --- Cancer --- therapeutic use. --- drug therapy. --- analogs & derivatives. --- pharmacology. --- Chemotherapy. --- Chimiothérapie --- Chemotherapy --- therapeutic use --- drug therapy --- analogs and derivatives --- pharmacology --- Cancer -- Chemotherapy. --- Alkaloids --- Diseases --- Therapeutics --- Antineoplastic Agents --- Biological Science Disciplines --- Therapeutic Uses --- Natural Science Disciplines --- Heterocyclic Compounds --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Pharmacology --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents --- Antiviral agents --- Treatment --- Oncology  . --- Cancer - Chemotherapy --- Camptothecin - therapeutic use --- Neoplasms - drug therapy --- Antineoplastic Agents, Phytogenic - therapeutic use --- Camptothecin - analogs and derivatives --- Camptothecin - pharmacology

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It was not long ago that clinicians would say,“study ed at the 1975 meeting revealed. Among them was the late complications of cancer treatments we give to one based on data collected by the Late Effects Study children? You must be joking! We can start worrying Group, an international consortium that consisted about that when we start curing them! Meanwhile, initially of ?ve, then ten, pediatric centers. This was cure must be our only aim. ”These practitioners were the ?rst large scale, cooperative unit of its kind, - only partially correct in what seemed to be a glaring ganized speci?cally for the purpose of studying the truth, for, in fact, increasing numbers of children late effects of cancer therapy (the study of delayed were beginning to survive their malignancy,and the complications had been included as part of the or- long-term consequences of therapy would soon be- inal design in the National Wilms Tumor Study come critical. launched in 1969) [1]. These historical notes demon- It is well to remember that the delayed conse- strate that the epidemiologic,statistical and reco- quences of a cancer treatment delivered to develop- keeping mechanisms necessary for studying lo- ing organisms were ?rst studied long ago. It has been term survivors effectively were in the process of be- 100 years since Perthes reported in 1903 that growth ing established decades before the meeting in 1975.

Kanker ; kinderen (0-12 jaar) --- Cancer in children --- Treatment --- Complications. --- Cancer in children. --- Cancer in children - Treatment - Complications. --- Adolescent --- Child --- Antineoplastic Agents --- Neoplasms --- Age Groups --- Diseases --- Therapeutic Uses --- Pharmacologic Actions --- Persons --- Named Groups --- Chemical Actions and Uses --- Chemicals and Drugs --- Oncology --- Medicine --- Health & Biological Sciences --- Complications --- Tumors in children --- Kanker ; kinderen --- Pediatric oncology --- Childhood cancer --- Pediatric cancer --- Medicine. --- Oncology. --- Nursing. --- Pediatrics. --- Medicine & Public Health. --- Children --- Oncology  . --- Paediatrics --- Pediatric medicine --- Clinical nursing --- Nurses and nursing --- Nursing process --- Care of the sick --- Tumors --- Health and hygiene

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This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. Through this approach, we recognize additionally the importance of nucleic acid damage beyond mutation and in pathological conditions other than carcinogenesis. The primary audience for the book would be research scientists and advanced postgraduate students, the book may also be of interest to clinicians with strong research interests. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before.

Life Sciences. --- Biochemistry, general. --- Life sciences. --- Biochemistry. --- Sciences de la vie --- Biochimie --- Antioxidants -- therapeutic use. --- Chemical mutagenesis. --- DNA Damage. --- DNA Repair Enzymes. --- DNA repair. --- Nucleic acids -- Oxidation. --- Oxidative Stress. --- Nucleic acids --- DNA repair --- Chemical mutagenesis --- DNA Repair --- Oxidative Stress --- Antioxidants --- DNA Damage --- DNA Repair Enzymes --- Stress, Physiological --- Genetic Processes --- Biochemical Processes --- Metabolism --- Protective Agents --- Enzymes --- Molecular Mechanisms of Pharmacological Action --- Physiological Processes --- Specialty Uses of Chemicals --- Genetic Phenomena --- Chemical Processes --- Physiological Effects of Drugs --- Pharmacologic Actions --- Biochemical Phenomena --- Metabolic Phenomena --- Enzymes and Coenzymes --- Phenomena and Processes --- Chemical Actions and Uses --- Chemicals and Drugs --- Physiological Phenomena --- Chemical Phenomena --- Biology - General --- Biochemistry --- Animal Biochemistry --- Human Anatomy & Physiology --- Chemistry --- Biology --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Oxidation --- Oxidation. --- Deoxyribonucleic acid repair --- Repair, DNA --- Repair mechanisms in DNA --- Polynucleotides --- Biosciences --- Sciences, Life --- Science --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Composition --- Genetic toxicology --- Mutagenesis --- Biochemical genetics --- Antimutagens --- Biomolecules