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Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.
Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Oncology
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Neovascularization. --- Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Blood-vessels --- Growth
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This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions. .
Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Oncology. --- Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Cancer research
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Neoplasm refers to an abnormal tissue growth that arises as a consequence of rapid cell proliferation and continues to grow abnormally even after terminating the stimuli that had instigated the change. It lacks partial or complete functional coordination with that of the normal tissues. Neoplasms are classified depending on the degree and type of tissues involved. Carcinogenesis is a multistep process where a plethora of endogenous and exogenous factors turns out genetic and epigenetic modifications, which collectively amend some critical cellular pathways controlling the proliferation, apoptosis, and differentiation. The cells having aberrant modifications are transformed into malignant ones of which the clonal expansion results in the development of cancer. This book provides the reader with a comprehensive overview of various cancer types along with their molecular mechanisms of initiation and progression. It also describes the current knowledge about the state-of-the-art measures being employed in cancer diagnosis and therapeutics. Particular attention is paid to make this book equally useful for students, practitioners, and expert scientists.
Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Life Sciences --- Genetics and Molecular Biology --- Oncology --- Biochemistry --- Cancer Biology
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The recent isolation and identification of the TGFß receptors, as well as their intracellular mediating proteins, has driven the development of many new methodologies and techniques for the study of TGFß. In Transforming Growth Factor-Beta Protocols, Philip H. Howe and a group of well-versed experimentalists present the first major collection of indispensable classic and cutting-edge TGFß assays. Described in great detail to ensure robust and successful results, these readily reproducible techniques range from the growth inhibition assay for TGFß to methodologies for monitoring its interactions with the mediating proteins. Extensive notes discuss potential pitfalls and provide tips on how to avoid failures, and throughout, emphasis is given to detailing those technical steps critical for experimental success that are often omitted in the primary literature. Concise and highly practical, Transforming Growth Factor-Beta Protocols provides today's molecular and cell biologists-both expert and novice-with time-tested methods for the identification and analysis of the signal transduction pathways by which TGFß induces and modulates physiological behavior.
Transforming growth factors-beta --- Transforming growth factors. --- TGF (Peptides) --- Tumor growth factors --- Biological response modifiers --- Growth factors --- Beta transforming growth factors --- TGF-beta (Peptide) --- Transforming growth factor beta --- Transforming growth factors --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists
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The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Medicine. --- Cancer research. --- Immunology. --- Molecular biology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Immunobiology --- Cancer research --- Clinical sciences --- Medical profession --- Tumors --- Cancer --- Neoplasm growth --- Tumor growth --- Tumor immunology --- Immunological aspects. --- Growth. --- Growth --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Pathology --- Physicians --- Oncology . --- Health Workforce
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The e-book is a timely overview of the roles played by inflammatory soluble mediators in neoplastic diseases. The topics addressed in this volume serve as a handy reference to investigators studying basic aspects of the malignant tumor growth, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological professionals seeking novel candidates for therapeutic intervention in cancer.
Tumors. --- Metastasis. --- Tumors --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- Cancer --- Neoplasm growth --- Tumor growth --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Cancer invasiveness --- Cancer of unknown primary origin --- Growth. --- Growth --- Dissemination --- Metastasis
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Control and automation systems are at the heart of our every day lives. This book is a collection of novel ideas and findings in these fields, published as part of the Special Issue on Control and Automation. The core focus of this issue was original ideas and potential contributions for both theory and practice. It received a total number of 21 submissions, out of which 7 were accepted. These published manuscripts tackle some novel approaches in control, including fractional order control systems, with applications in robotics, biomedical engineering, electrical engineering, vibratory systems, and wastewater treatment plants. This Special Issue has gathered a selection of novel research results regarding control systems in several distinct research areas. We hope that these papers will evoke new ideas, concepts, and further developments in the field.
Technology: general issues --- fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system --- fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system
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A wide range of ongoing research in the areas of controller design and information engineering reveals that the pace of technological change in this domain seems to be accelerating. The primary focus is on futuristic segments ranging from robotics, genomics to chemical feedstock and electrical storage. The main objective of this special issue was to provide a forum for researchers and practitioners to exchange their latest theoretical and technological achievements and to identify critical issues and challenges for future investigation on topics regarding advanced automation and control techniques based on information system technologies.
Technology: general issues --- fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system --- fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system
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A wide range of ongoing research in the areas of controller design and information engineering reveals that the pace of technological change in this domain seems to be accelerating. The primary focus is on futuristic segments ranging from robotics, genomics to chemical feedstock and electrical storage. The main objective of this special issue was to provide a forum for researchers and practitioners to exchange their latest theoretical and technological achievements and to identify critical issues and challenges for future investigation on topics regarding advanced automation and control techniques based on information system technologies.
Technology: general issues --- fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system --- n/a
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