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Oncology. Neoplasms --- kwaadaardige gezwellen --- Sarcoma --- Sarcome --- Periodicals. --- Périodiques --- Sarcoma. --- Health Sciences --- Life Sciences --- Clinical Medicine --- General and Others --- Micro and Molecular Biology --- oncology --- sarcoma --- Oncology. --- Connective Tissue. --- Cancer --- Tumors --- Sarcoma, Epithelioid --- Sarcoma, Soft Tissue --- Sarcoma, Spindle Cell --- Epithelioid Sarcoma --- Epithelioid Sarcomas --- Sarcomas --- Sarcomas, Epithelioid --- Sarcomas, Soft Tissue --- Sarcomas, Spindle Cell --- Soft Tissue Sarcoma --- Soft Tissue Sarcomas --- Spindle Cell Sarcoma --- Spindle Cell Sarcomas

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It is now well established that sleep and wakefulness are locally regulated. In fact, typical sleep hallmarks, such as slow waves and spindles, display a clear regional modulation based on maturational and experience-dependent brain plasticity. Of note, these regional changes have been suggested to reflect the off-line processing and transformation of wake-dependent brain modifications, in line with a direct involvement of sleep in learning and memory consolidation. In addition, recent work showed that islands of wakefulness and sleep may often coexist in the same individual. Indeed, the incidence of local sleep-like episodes during wakefulness increases following sleep restriction or deprivation, but also as a consequence of the reiterated or extended ‘use’ of task-related brain areas. Such sleep-like activity seems to represent an index of ‘functional fatigue’ and may have a significant impact on behavior and cognition. On the other hand, local wake-like activity may occur during sleep and has been suggested to be involved in the generation and characterization of dream experiences. Finally, alterations in the balance between local aspects of sleep and wakefulness may contribute to explain symptoms commonly attributed to many sleep disorders, such as insomnia or sleepwalking. However, preliminary evidence has also pointed to their potential involvement in neurological (e.g., stroke) and psychiatric (e.g., major depression) pathological conditions. This Research Topic collects articles related to the investigation and characterization of local aspects of sleep and wakefulness.

Science: general issues --- Neurosciences --- Local sleep --- hd-EEG --- MEG --- fMRI-EEG --- Sleep --- K-complex --- Slow Wave --- sleep spindle --- connectivity --- plasticity --- Disconnection --- Local sleep --- hd-EEG --- MEG --- fMRI-EEG --- Sleep --- K-complex --- Slow Wave --- sleep spindle --- connectivity --- plasticity --- Disconnection

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Cell Nucleus. --- Chromosomes --- 576.316 --- 576.311.348.7 --- 576.353 --- Spindle (Cell division) --- #WPLT:dd.prof.J.Vendrig --- Cell organelles --- Meiosis --- Mitosis --- Chromosome theory --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Genetics --- Karyokinesis --- Linkage (Genetics) --- Cell Nuclei --- Nuclei, Cell --- Nucleus, Cell --- physiology. --- Microtubulars --- Mitosis. Karyokinesis. Indirect cell division --- Chromosomes. --- Cell nucleus --- CHROMOSOMES --- physiology --- 576.353 Mitosis. Karyokinesis. Indirect cell division --- 576.311.348.7 Microtubulars --- 576.316 Chromosomes --- Spindle (Cell division). --- Cell nucleus. --- Spindle (cell division). --- Physiology. --- Cell Nucleus

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Microtubules --- Microtubules. --- 576.311.348.7 --- Microtubule --- Spindle Apparatus --- Tubulin Modulators --- Microtubulars --- 576.311.348.7 Microtubulars --- #WSCH:FYS3 --- Histology. Cytology

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Fluorodeoxyglucose F18 --- Fluorine Radioisotopes --- Soft Tissue Neoplasms --- Dideoxynucleosides --- Tomography, Emission-Computed --- Sarcoma --- Sarcoma, Epithelioid --- Sarcoma, Soft Tissue --- Sarcoma, Spindle Cell --- Epithelioid Sarcoma --- Epithelioid Sarcomas --- Sarcomas --- Sarcomas, Epithelioid --- Sarcomas, Soft Tissue --- Sarcomas, Spindle Cell --- Soft Tissue Sarcoma --- Soft Tissue Sarcomas --- Spindle Cell Sarcoma --- Spindle Cell Sarcomas --- ddNus --- 2',3'-Dideoxynucleosides --- Dideoxyribonucleosides --- 2',3' Dideoxynucleosides --- Neoplasm, Soft Tissue --- Neoplasms, Soft Tissue --- Soft Tissue Neoplasm --- Neoplasms, Connective Tissue --- Radioisotopes, Fluorine --- Fluorine --- 18F-FDG --- Fluorine-18-fluorodeoxyglucose --- Fluorodeoxyglucose F 18 --- 18F Fluorodeoxyglucose --- 18FDG --- 2-Fluoro-2-deoxy-D-glucose --- 2-Fluoro-2-deoxyglucose --- Fludeoxyglucose F 18 --- 2 Fluoro 2 deoxy D glucose --- 2 Fluoro 2 deoxyglucose --- F 18, Fludeoxyglucose --- F 18, Fluorodeoxyglucose --- F18, Fluorodeoxyglucose --- Fluorine 18 fluorodeoxyglucose --- Fluorodeoxyglucose, 18F --- diagnostic use --- radionuclide imaging --- methods --- Theses --- diagnostic use.