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Biotic and abiotic stress factors deliver a huge impact on plant life. Biotic stress factors such as damage through pathogens or herbivore attack, as well as abiotic stress factors like variation in temperature, rainfall and salinity, have placed the plant kingdom under constant challenges for survival. As a consequence, global agricultural and horticultural productivity has been disturbed to a large extent. Being sessile in nature, plants cannot escape from the stress, and instead adapt changes within their system to overcome the adverse conditions. These changes include physiological, developmental and biochemical alterations within the plant body which influences the genome, proteome and metabolome profiles of the plant. Since proteins are the ultimate players of cellular behavior, proteome level alterations during and recovery period of stress provide direct implications of plant responses towards stress factors. With current advancement of modern high-throughput technologies, much research has been carried out in this field. This e-book highlights the research and review articles that cover proteome level changes during the course or recovery period of various stress factors in plant life. Overall, the chapters in this e-book has provided a wealth of information on how plants deal with stress from a proteomics perspective.

Infection --- signaling events during stress --- Quantitative Proteomics --- heavy metal stress --- plant proteomics --- drought --- high temperature --- Salinity

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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

natural compounds --- anti-obesity drugs --- high fat diet --- Ishige okamurae --- fat --- zebrafish Nile red fat metabolism assay --- physical exercise --- JAK2-STAT3 --- metabolite profiling --- obesity --- chlorophyll derivatives --- brown seaweed --- Skate skin --- PPAR? --- marine alga --- marine biodiscovery --- skate skin --- lipolytic --- leptin --- uncoupling protein 1 --- 3T3-L1 cells --- glucolipid metabolism disorder --- nutrition --- bioactivity --- chitosan oligosaccharide --- diphlorethohydroxycarmalol (DPHC) --- nutraceuticals --- whole small animal models --- high-fat diet --- adipocyte --- dyslipidemia --- bioactivity screening --- peroxisome proliferator-activated receptor gamma --- white adipose tissue --- antiobesity --- fatty liver disease --- thermal proteome profiling --- inflammation --- cyanobacteria --- Raja kenojei --- Arthrospira maxima --- cellularity --- adipocytes --- bioactive compound --- collagen peptide --- double-blind --- bisabolane-related compounds --- proliferation --- fatty acid metabolism --- cholesterol metabolism --- collagen --- randomized controlled trial --- mechanisms of action --- murine pre-adipocytes --- adipogenesis --- fucan --- marine sponges --- label-free quantitative proteomics --- diabetes --- body fat

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Lysosomal storage disorders are a heterogenoeus group of rare genetic conditions affecting worldwide population and often exhibiting severe clinical manifestations. During the last two decades, the joined collaboration between scientists and clinicians has allowed to offer valuable therapeutic options to affected patients. Therefore, the tight connection between basic science and clinical medicine represents the gold standard approach to these disorders. In this context, the present book collects a piece of current scientific advances in the knowledge of disease pathogenesis and in the development of novel diagnostic and therapeutic strategies for some of these diseases. Altogether, these articles define and recapitulate which essential steps are required during the clinical management of a rare inherited disorder and describe forthcoming advances and a breakthrough in the field of lysosomal diseases.

Medicine --- mucopolysaccharidosis IIIB --- quantitative proteomics --- NAGLU --- lysosomes --- Gaucher disease --- bone involvement --- enzyme replacement therapy --- substrate reduction therapy --- Osteoimmunology --- RANK/RANKL --- Osteopontin --- MIP-1β --- mucolipidosis II --- sortilin --- TGF-beta --- cathepsin D --- Fabry disease --- alpha-galactosidase A --- endocytosis --- lysosome --- IGF2R/M6P --- clathrin --- chloroquine --- lysosomal diseases --- precision medicine --- pharmacological chaperones --- gene therapy. --- Pompe disease --- lysosomal targeting --- autophagy --- gene therapy --- muscle --- satellite cells --- rhGAA --- glycogen --- lysosomal α-glucosidase --- GAA biomarker --- Gaucher Disease --- Wnt/β-catenin --- Dkk1 --- Wnt3a --- iPSC --- neuronopathy --- Krabbe disease --- Twitcher mouse --- psychosine --- visual system --- visual cortex --- astrogliosis --- mucopolysaccharidosis type I --- Hurler syndrome --- hematopoietic stem cell transplantations --- animal models --- experimental therapies --- axon guidance --- lysosomal storage disorders --- neuronal circuit --- α-galactosidase A --- A4GALT --- globotriaosylceramide (Gb3) --- globotriaosyl-sphingosine (lysoGb3) --- pharmacological chaperone therapy --- exosomes --- endocytic pathways --- neurodegenerative disease --- Parkinson disease --- lysosomal storage disorder --- viral vectors --- newborn screening --- variant interpretation --- second tier test --- tandem mass spectrometry --- lyso-Gb3 --- dried blood spot --- GLA gene --- globotriaosylsphingosine --- biomarkers --- mucopolysaccharidosis IIIB --- quantitative proteomics --- NAGLU --- lysosomes --- Gaucher disease --- bone involvement --- enzyme replacement therapy --- substrate reduction therapy --- Osteoimmunology --- RANK/RANKL --- Osteopontin --- MIP-1β --- mucolipidosis II --- sortilin --- TGF-beta --- cathepsin D --- Fabry disease --- alpha-galactosidase A --- endocytosis --- lysosome --- IGF2R/M6P --- clathrin --- chloroquine --- lysosomal diseases --- precision medicine --- pharmacological chaperones --- gene therapy. --- Pompe disease --- lysosomal targeting --- autophagy --- gene therapy --- muscle --- satellite cells --- rhGAA --- glycogen --- lysosomal α-glucosidase --- GAA biomarker --- Gaucher Disease --- Wnt/β-catenin --- Dkk1 --- Wnt3a --- iPSC --- neuronopathy --- Krabbe disease --- Twitcher mouse --- psychosine --- visual system --- visual cortex --- astrogliosis --- mucopolysaccharidosis type I --- Hurler syndrome --- hematopoietic stem cell transplantations --- animal models --- experimental therapies --- axon guidance --- lysosomal storage disorders --- neuronal circuit --- α-galactosidase A --- A4GALT --- globotriaosylceramide (Gb3) --- globotriaosyl-sphingosine (lysoGb3) --- pharmacological chaperone therapy --- exosomes --- endocytic pathways --- neurodegenerative disease --- Parkinson disease --- lysosomal storage disorder --- viral vectors --- newborn screening --- variant interpretation --- second tier test --- tandem mass spectrometry --- lyso-Gb3 --- dried blood spot --- GLA gene --- globotriaosylsphingosine --- biomarkers

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Advancements in high-throughput “Omics” techniques have revolutionized plant molecular biology research. Proteomics offers one of the best options for the functional analysis of translated regions of the genome, generating a wealth of detailed information regarding the intrinsic mechanisms of plant stress responses. Various proteomic approaches are being exploited extensively for elucidating master regulator proteins which play key roles in stress perception and signaling, and these approaches largely involve gel-based and gel-free techniques, including both label-based and label-free protein quantification. Furthermore, post-translational modifications, subcellular localization, and protein–protein interactions provide deeper insight into protein molecular function. Their diverse applications contribute to the revelation of new insights into plant molecular responses to various biotic and abiotic stressors.

14-3-3 proteins --- n/a --- targeted two-dimensional electrophoresis --- somatic embryogenesis --- nitrogen metabolism --- subtilase --- Sporisorium scitamineum --- non-orthodox seed --- antioxidant activity --- sweet potato plants infected by SPFMV --- photosynthesis --- B. acuminata petals --- chlorophyll deficiency --- seed proteomics --- imbibition --- pollination --- Sarpo Mira --- qRT-PCR --- holm oak --- tuber phosphoproteome --- isobaric tags for relative and absolute quantitation (iTRAQ) --- Quercus ilex --- nucleotide pyrophosphatase/phosphodiesterase --- lettuce --- ?-subunit --- protein phosphatase --- germination --- drought stress --- pyruvate biosynthesis --- weakening of carbon metabolism --- differential proteins --- heterotrimeric G protein --- organ --- LC-MS-based proteomics --- potato proteomics --- smut --- gel-free/label-free proteomics --- ? subunit --- shotgun proteomics --- 2D --- chloroplast --- proteome functional annotation --- Phalaenopsis --- Clematis terniflora DC. --- wheat --- Dn1-1 --- carbon metabolism --- physiological responses --- Zea mays --- phenylpropanoid biosynthesis --- ISR --- mass spectrometric analysis --- patatin --- leaf --- pea (Pisum sativum L.) --- maize --- ergosterol --- Camellia sinensis --- seed storage proteins --- silver nanoparticles --- elevated CO2 --- metacaspase --- SPV2 and SPVG --- SnRK1 --- MALDI-TOF/TOF --- (phospho)-proteomics --- leaf spot --- rice isogenic line --- wheat leaf rust --- pathway analysis --- phosphoproteome --- sugarcane --- senescence --- Oryza sativa L. --- Arabidopsis thaliana --- heat stress --- gene ontology --- innate immunity --- Pseudomonas syringae --- bolting --- chlorophylls --- shoot --- Simmondsia chinensis --- RT-qPCR --- stresses responses --- Solanum tuberosum --- seeds --- GC-TOF-MS --- sucrose --- proteome --- Puccinia recondita --- cultivar --- Zea mays L. --- secondary metabolism --- ROS --- Ricinus communis L. --- after-ripening --- cadmium --- Stagonospora nodorum --- virus induced gene silencing --- quantitative proteomics --- sweet potato plants non-infected by SPFMV --- affinity chromatography --- population variability --- GS3 --- fungal perception --- ammonium --- transcriptome profiling --- mass spectrometry analysis --- papain-like cysteine protease (PLCP) --- cold stress --- nitrate --- late blight disease --- early and late disease stages --- seed imbibition --- lesion mimic mutant --- protease --- proteome map --- seed dormancy --- petal --- 2-DE proteomics --- 2D DIGE --- root --- Phytophthora infestans --- differentially abundant proteins (DAPs) --- polyphenol oxidase --- degradome --- flavonoid --- 14-3-3 --- caspase-like --- proteomics --- RGG4 --- co-infection --- plasma membrane --- chlorotic mutation --- Medicago sativa --- RGG3 --- glycolysis --- barley --- 2-DE --- protein phosphorylation --- western blotting --- N utilization efficiency --- rice --- plant pathogenesis responses --- high temperature --- data-independent acquisition --- pattern recognition receptors --- vegetative storage proteins --- leaf cell wall proteome --- plant-derived smoke --- iTRAQ --- starch --- proteome profiling --- Morus