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Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Phagocytosis. --- Cytology. --- Autophagy. --- Cell biology --- Cellular biology --- Biology --- Cells --- Antigen-antibody reactions --- Endocytosis --- Immune response --- Immunology --- Phagosomes --- Pinocytosis --- Reticulo-endothelial system --- Tuftsin --- Autophagic vacuoles. --- Autophagocytosis --- Life Sciences --- Microbiology --- Genetics and Molecular Biology --- Cytology --- Biochemistry

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Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a series of up-to-date essays (chapters) that describe the present knowledge on the various steps of the phagocytic process from initial cell contact, through internalization of the foreign particle, to the final phagosome formation where the phagocytosed particle is destroyed.

Phagocytosis. --- Antigen-antibody reactions --- Endocytosis --- Immune response --- Immunology --- Phagosomes --- Pinocytosis --- Reticulo-endothelial system --- Tuftsin --- Cytology. --- Oncology. --- Immunology. --- Biochemistry. --- Microbiology. --- Cell Biology. --- Cancer Research. --- Biochemistry, general. --- Microbial biology --- Biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Cell biology. --- Cancer research. --- Cancer research

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The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpoint of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists with disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important

Phagocytosis. --- Phagocytes. --- Macrophages. --- Microbial invasiveness. --- Invasion, Microbial --- Invasiveness, Microbial --- Microbial invasion --- Microorganisms --- Virulence (Microbiology) --- Histiocytes --- Mononuclear phagocytes --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Cells --- Immune system --- Antigen-antibody reactions --- Endocytosis --- Immune response --- Immunology --- Phagosomes --- Pinocytosis --- Tuftsin --- Invasion --- Invasiveness

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Immunology. Immunopathology --- Immunity, Cellular --- Phagocytosis --- Cellular immunity --- Immunité cellulaire --- Phagocytose --- Cellular immunity. --- Phagocytosis. --- Phagocytoses --- Leukocytes --- Macrophages --- Opsonin Proteins --- Phagosomes --- Cellular Immune Response --- Cell-Mediated Immunity --- Cell Mediated Immunity --- Cell-Mediated Immunities --- Cellular Immune Responses --- Cellular Immunities --- Cellular Immunity --- Immune Response, Cellular --- Immune Responses, Cellular --- Immunities, Cell-Mediated --- Immunities, Cellular --- Immunity, Cell-Mediated --- Response, Cellular Immune --- Lymphokines --- T-Lymphocytes --- Interleukin-12 --- Antigen-antibody reactions --- Endocytosis --- Immune response --- Immunology --- Pinocytosis --- Reticulo-endothelial system --- Tuftsin --- Cell-mediated immunity --- Cellular immunology --- Clonal selection theory --- Immunity --- Immunité cellulaire --- Immunity, Cellular.

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Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Autophagic vacuoles. --- Autophagy. --- Cellular immunity. --- Immunity, Innate. --- Infection -- immunology. --- Cellular immunity --- Autophagic vacuoles --- Infection --- Immunity, Innate --- Autophagy --- Immunity --- Bacterial Infections and Mycoses --- Cell Death --- Phagocytosis --- Immune System Phenomena --- Cell Physiological Processes --- Diseases --- Endocytosis --- Phenomena and Processes --- Cell Physiological Phenomena --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Phagocytosis. --- Cell-mediated immunity --- Cellular immunology --- Medicine. --- Immunology. --- Medical microbiology. --- Virology. --- Biomedicine. --- Medical Microbiology. --- Microbiology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Antigen-antibody reactions --- Immune response --- Immunology --- Phagosomes --- Pinocytosis --- Reticulo-endothelial system --- Tuftsin --- Clonal selection theory --- Medical virology. --- Microbiology. --- Microbial biology --- Microorganisms --- Medical microbiology --- Virology --- Virus diseases