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Thanks to their rich chemodiversity, marine natural products represent a unique source of new bioactive metabolites. As the new leading compounds in drug discovery and development, these molecules may represent challenges for the treatment of a number of human diseases, attracting the attention of many researchers during their chemical and biological studies. This Special Issue covers all fields of drugs research in which marine natural products are involved, including their isolation and characterization, biological activities, and medicinal applications as well as synthetic approaches and their related analogues. The cover picture shows “The Nudibranch mollusk Godiva quadricolor on a sponge, reflected under the surface during the low tide. Fusaro Lagoon, Bacoli (Naples)”.

alginate --- Sargassum duplicatum --- okra --- antioxidant --- diabetic --- wound healing --- sulfavant --- sulfoquinovosyldiacylglycerols --- sulfoglycolipids --- mass spectrometry --- UHPLC-MS --- lipids --- cancer therapy --- gold nanoparticles --- marine products --- natural products --- photosensitizer --- purpurin 18 --- reactive oxygen species --- seaweed --- biosilica --- diatom frustule --- sustainable production --- drug delivery --- Sargassum ilicifolium --- mangosteen rind --- diabetic mice --- Aquimarina sp. --- diketopiperazine --- N-phenethylacetamide --- epithelial-mesenchymal transition (EMT) --- A549 cells --- n/a

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Myxobacteria are fascinating and important prokaryotes. They have large genomes and exhibit a wide range of interesting behaviors, including multicellular fruiting body formation, social interaction, predation, and secondary metabolite production. Substantial progress is being made in understanding their ecological roles and the evolutionary forces that have shaped their phenotypes and behaviors. Novel species of myxobacteria are regularly described, often producing unusual metabolites and enzymes which can be of significant biotechnological interest. Molecular studies, ranging in subject from individual enzymes to entire ‘omes, continue to provide rich insights into myxobacterial biology. This collected volume brings together five research articles and three reviews, to provide a snapshot of current myxobacterial research in all its diversity.

carotenoids --- comparative genomics --- development --- fruiting body formation --- one-component systems --- quorum signalling --- two-component systems --- myxobacteria --- Myxococcales --- germination --- bacterial cell wall --- sporulation --- morphology --- photoreceptor --- photosensitizer --- photoregulation --- singlet oxygen --- plasmalogens --- CarF --- vitamin B12 --- CarH --- ECF-sigma --- CarD-CdnL --- microbial food web --- trophic interactions --- predator–prey interactions --- mesopredator --- social bacteria --- nematodes --- experimental community --- behavior --- Myxococcus sp. --- Corallococcus sp. --- Melittangium sp. --- Archangium sp. --- biosynthetic gene clusters --- Myxococcus xanthus --- phase contrast microscopy --- fluorescence microscopy --- aggregation --- rippling --- deep learning --- generative adversarial network --- pretator-prey coevolution --- antagonism --- mucoidy --- predatory bacteria --- bacterial predation --- prey diversity --- negative frequency dependence --- experimental evolution --- MyxoEE-6 --- functional genomics --- genome evolution --- genome organisation --- pan-genome --- proteomics --- taxonomy --- transcriptomics --- n/a --- predator-prey interactions

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Myxobacteria are fascinating and important prokaryotes. They have large genomes and exhibit a wide range of interesting behaviors, including multicellular fruiting body formation, social interaction, predation, and secondary metabolite production. Substantial progress is being made in understanding their ecological roles and the evolutionary forces that have shaped their phenotypes and behaviors. Novel species of myxobacteria are regularly described, often producing unusual metabolites and enzymes which can be of significant biotechnological interest. Molecular studies, ranging in subject from individual enzymes to entire ‘omes, continue to provide rich insights into myxobacterial biology. This collected volume brings together five research articles and three reviews, to provide a snapshot of current myxobacterial research in all its diversity.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- carotenoids --- comparative genomics --- development --- fruiting body formation --- one-component systems --- quorum signalling --- two-component systems --- myxobacteria --- Myxococcales --- germination --- bacterial cell wall --- sporulation --- morphology --- photoreceptor --- photosensitizer --- photoregulation --- singlet oxygen --- plasmalogens --- CarF --- vitamin B12 --- CarH --- ECF-sigma --- CarD-CdnL --- microbial food web --- trophic interactions --- predator-prey interactions --- mesopredator --- social bacteria --- nematodes --- experimental community --- behavior --- Myxococcus sp. --- Corallococcus sp. --- Melittangium sp. --- Archangium sp. --- biosynthetic gene clusters --- Myxococcus xanthus --- phase contrast microscopy --- fluorescence microscopy --- aggregation --- rippling --- deep learning --- generative adversarial network --- pretator-prey coevolution --- antagonism --- mucoidy --- predatory bacteria --- bacterial predation --- prey diversity --- negative frequency dependence --- experimental evolution --- MyxoEE-6 --- functional genomics --- genome evolution --- genome organisation --- pan-genome --- proteomics --- taxonomy --- transcriptomics --- carotenoids --- comparative genomics --- development --- fruiting body formation --- one-component systems --- quorum signalling --- two-component systems --- myxobacteria --- Myxococcales --- germination --- bacterial cell wall --- sporulation --- morphology --- photoreceptor --- photosensitizer --- photoregulation --- singlet oxygen --- plasmalogens --- CarF --- vitamin B12 --- CarH --- ECF-sigma --- CarD-CdnL --- microbial food web --- trophic interactions --- predator-prey interactions --- mesopredator --- social bacteria --- nematodes --- experimental community --- behavior --- Myxococcus sp. --- Corallococcus sp. --- Melittangium sp. --- Archangium sp. --- biosynthetic gene clusters --- Myxococcus xanthus --- phase contrast microscopy --- fluorescence microscopy --- aggregation --- rippling --- deep learning --- generative adversarial network --- pretator-prey coevolution --- antagonism --- mucoidy --- predatory bacteria --- bacterial predation --- prey diversity --- negative frequency dependence --- experimental evolution --- MyxoEE-6 --- functional genomics --- genome evolution --- genome organisation --- pan-genome --- proteomics --- taxonomy --- transcriptomics

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Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.

Bacillus anthracis --- immunoassay --- single-domain antibody --- genetic fusion --- Beta galactosidase --- P-type ATPase --- nanobody --- llama --- Zinc-transport --- Zinc-transporting P-ATPase --- ZntA --- TNF --- fluorescent --- nanobodies --- sensor --- anti-cytokine therapy --- autoimmune disease --- Western equine encephalitis virus --- MagPlex --- toxin --- antibody --- camelid --- vaccine --- biodefense --- hydrogen exchange-mass spectrometry --- virus --- formatting --- Fc-domain --- half-life --- ischemia --- stroke --- MCAO --- single domain antibodies --- phage display --- intrabody --- intracellular antibody --- GTPase RHO --- BRET --- RAS --- chromobodies --- live-cell imaging --- compound screening --- cellular models --- single-domain antibody fragments --- molecular imaging --- molecular therapy --- nuclear imaging --- targeted fluorescence imaging --- intraoperative imaging --- Nanobody --- Single Domain Antibody --- Cancer --- Immunotherapy --- Imaging --- influenza --- influenza B virus --- hemagglutinin --- single domain antibody --- NanobodyTM --- yeast display --- epitope mapping --- GFP --- C. elegans --- development --- drosophila --- zebrafish --- targeted photodynamic therapy --- hepatocyte growth factor receptor --- HGFR --- c-Met --- Met --- VHH --- photosensitizer --- single-domain antibodies --- neurodegenerative diseases --- brain imaging --- blood–brain barrier --- delivery --- Aids --- HIV --- Llama Antibodies --- bi-specific VHH --- pepscan --- competition studies --- co-crystallisation --- n/a --- blood-brain barrier

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This book contains the Nutrients Special Issue "Nutrition and Human Oral Health" edited by Dr. Kirstin Vach and Prof. Dr. Johan Woelber. It includes 18 wonderful publications that provide an outline of current scientific work in the field of nutritional dentistry.

Research & information: general --- Biology, life sciences --- Food & society --- severe caries --- tooth decay --- dental --- early childhood --- early childhood caries --- malnutrition --- undernutrition --- stunting --- growth and development --- Punica granatum --- Vaccinium myrtillus --- Aronia melanocarpa --- punicalagin --- cyanidin 3-glucoside and hyperoside --- Streptococcus mutans --- Streptococcus sobrinus --- photosensitizer --- antimicrobial photodynamic treatment --- compositional data --- ratio fractions --- nutrition --- microbiome --- oral health --- pellicle --- linseed oil --- fatty acid --- ultrastructure --- in situ --- dental status --- older people --- elderly people --- systematic review --- dental caries --- diet therapy --- dentists --- dental auxiliaries --- nutritionists --- dietitian --- surveys and questionnaires --- qualitative research --- review --- periodontitis --- periodontal diseases --- scaling and root planning --- diet --- dietary protein --- Inula viscosa --- initial adhesion --- colony-forming units (CFU) --- live/dead staining --- fluorescence microscopy --- dietary patterns --- periodontal disease --- clinical attachment loss --- DMFT --- ketogenic diet --- periodontal inflammation --- gingivitis --- periodontal --- bone loss --- LDL --- vitamin D --- CBCT --- radiographic bone loss --- sarcopenic dysphagia --- sarcopenia --- dysphagia --- osteoporosis --- elderly --- probiotic --- clinical parameters --- prevention --- therapeutics --- questionnaires --- erosion --- young adults --- tooth wear --- dentistry --- inflammation --- Mediterranean diet --- periodontology --- caries --- stable isotope analysis --- bioarcheology --- severe caries --- tooth decay --- dental --- early childhood --- early childhood caries --- malnutrition --- undernutrition --- stunting --- growth and development --- Punica granatum --- Vaccinium myrtillus --- Aronia melanocarpa --- punicalagin --- cyanidin 3-glucoside and hyperoside --- Streptococcus mutans --- Streptococcus sobrinus --- photosensitizer --- antimicrobial photodynamic treatment --- compositional data --- ratio fractions --- nutrition --- microbiome --- oral health --- pellicle --- linseed oil --- fatty acid --- ultrastructure --- in situ --- dental status --- older people --- elderly people --- systematic review --- dental caries --- diet therapy --- dentists --- dental auxiliaries --- nutritionists --- dietitian --- surveys and questionnaires --- qualitative research --- review --- periodontitis --- periodontal diseases --- scaling and root planning --- diet --- dietary protein --- Inula viscosa --- initial adhesion --- colony-forming units (CFU) --- live/dead staining --- fluorescence microscopy --- dietary patterns --- periodontal disease --- clinical attachment loss --- DMFT --- ketogenic diet --- periodontal inflammation --- gingivitis --- periodontal --- bone loss --- LDL --- vitamin D --- CBCT --- radiographic bone loss --- sarcopenic dysphagia --- sarcopenia --- dysphagia --- osteoporosis --- elderly --- probiotic --- clinical parameters --- prevention --- therapeutics --- questionnaires --- erosion --- young adults --- tooth wear --- dentistry --- inflammation --- Mediterranean diet --- periodontology --- caries --- stable isotope analysis --- bioarcheology