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Optofluidic devices are of high scientific and industrial interest in chemistry, biology, material science, pharmacy, and medicine. In recent years, they have experienced strong development because of impressive achievements in the synergistic combination of photonics and micro/nanofluidics. Sensing and/or lasing platforms showing unprecedented sensitivities in extremely small analyte volumes, and allowing real-time analysis within a lab-on-a-chip approach, have been developed. They are based on the interaction of fluids with evanescent waves induced at the surface of metallic or photonic structures, on the implementation of microcavities to induce optical resonances in the fluid medium, or on other interactions of the microfluidic systems with light. In this context, a large variety of optofluidic devices has emerged, covering topics such as cell manipulation, microfabrication, water purification, energy production, catalytic reactions, microparticle sorting, micro-imaging, or bio-sensing. Moreover, the integration of these optofluidic devices in larger electro-optic platforms represents a highly valuable improvement towards advanced applications, such as those based on surface plasmon resonances that are already on the market. In this Special Issue, we invited the scientific community working in this rapidly evolving field to publish recent research and/or review papers on these optofluidic devices and their applications.

History of engineering & technology --- opto-fluidics --- micro-manipulation --- cells --- microparticles --- electrowetting display --- aperture ratio --- driving waveform --- hysteresis characteristic --- ink distribution --- response speed --- optofluidics --- ocean monitoring --- colorimetric method --- optoelectrokinetics --- optically-induced dielectrophoresis --- micro/nanomaterials --- separation --- fabrication --- electro-fluidic display --- organic dye --- colored oil --- photo-stability --- micro-thermometry --- laser induced fluorescence --- droplet microfluidics --- zinc oxide --- rhodamine B --- rhodamine 6G --- photocatalysis --- microreactor --- photocatalytic water purification --- paper --- 3D hydrodynamic focusing --- optofluidic --- lab-on-a-chip --- biosensor --- microscale channel --- microfluidic --- liquid-core waveguide --- single layer --- reservoir effect --- sensor --- surface plasmon resonance --- nanohole array --- mechanical properties --- nanofluidic --- nanoplasmonic --- dissolved oxygen --- silver nanoprisms --- colorimetry --- n/a

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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.

polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate–poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- n/a --- alginate-poloxamer copolymer

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Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.

Research & information: general --- Biology, life sciences --- single-cell RNA sequencing --- cholestatic liver injury --- hepatocyte heterogeneity --- inflammation --- liver tissue repair --- single cell mass cytometry --- single cell proteomics --- non-small cell lung cancer --- three-dimensional tissue culture --- snRNA-seq --- RNA velocity --- cluster analysis --- cardiomyocytes --- seurat --- cell heterogeneity --- sarcoma --- single-cell analysis --- total mRNA level --- transcriptome size --- proteomics --- immunofluorescence --- immunohistochemistry --- protein --- genome --- biomedical applications --- commercialization --- protein characterization --- conventional approaches --- microfluidic technologies --- single cell --- infectious disease --- pathophysiology --- therapeutics --- diagnostics --- microfluidics --- single-cell cloning --- monoclonal cell lines --- single-neuron models --- mapping --- electrophysiological recording --- isolation --- therapy --- micro/nanofluidic devices --- microelectrode array --- transfection --- artificial intelligence --- localized high-risk prostate cancer --- circulating tumor cells --- three-dimensional (3-D) telomere profiling --- laser microdissection --- whole-exome genome sequencing --- somatic single nucleotide variants --- copy number alterations --- precision medicine --- single-cell RNA sequencing --- cholestatic liver injury --- hepatocyte heterogeneity --- inflammation --- liver tissue repair --- single cell mass cytometry --- single cell proteomics --- non-small cell lung cancer --- three-dimensional tissue culture --- snRNA-seq --- RNA velocity --- cluster analysis --- cardiomyocytes --- seurat --- cell heterogeneity --- sarcoma --- single-cell analysis --- total mRNA level --- transcriptome size --- proteomics --- immunofluorescence --- immunohistochemistry --- protein --- genome --- biomedical applications --- commercialization --- protein characterization --- conventional approaches --- microfluidic technologies --- single cell --- infectious disease --- pathophysiology --- therapeutics --- diagnostics --- microfluidics --- single-cell cloning --- monoclonal cell lines --- single-neuron models --- mapping --- electrophysiological recording --- isolation --- therapy --- micro/nanofluidic devices --- microelectrode array --- transfection --- artificial intelligence --- localized high-risk prostate cancer --- circulating tumor cells --- three-dimensional (3-D) telomere profiling --- laser microdissection --- whole-exome genome sequencing --- somatic single nucleotide variants --- copy number alterations --- precision medicine

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Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.

Research & information: general --- Biology, life sciences --- single-cell RNA sequencing --- cholestatic liver injury --- hepatocyte heterogeneity --- inflammation --- liver tissue repair --- single cell mass cytometry --- single cell proteomics --- non-small cell lung cancer --- three-dimensional tissue culture --- snRNA-seq --- RNA velocity --- cluster analysis --- cardiomyocytes --- seurat --- cell heterogeneity --- sarcoma --- single-cell analysis --- total mRNA level --- transcriptome size --- proteomics --- immunofluorescence --- immunohistochemistry --- protein --- genome --- biomedical applications --- commercialization --- protein characterization --- conventional approaches --- microfluidic technologies --- single cell --- infectious disease --- pathophysiology --- therapeutics --- diagnostics --- microfluidics --- single-cell cloning --- monoclonal cell lines --- single-neuron models --- mapping --- electrophysiological recording --- isolation --- therapy --- micro/nanofluidic devices --- microelectrode array --- transfection --- artificial intelligence --- localized high-risk prostate cancer --- circulating tumor cells --- three-dimensional (3-D) telomere profiling --- laser microdissection --- whole-exome genome sequencing --- somatic single nucleotide variants --- copy number alterations --- precision medicine --- n/a

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• Reference Manager
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Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.

single-cell RNA sequencing --- cholestatic liver injury --- hepatocyte heterogeneity --- inflammation --- liver tissue repair --- single cell mass cytometry --- single cell proteomics --- non-small cell lung cancer --- three-dimensional tissue culture --- snRNA-seq --- RNA velocity --- cluster analysis --- cardiomyocytes --- seurat --- cell heterogeneity --- sarcoma --- single-cell analysis --- total mRNA level --- transcriptome size --- proteomics --- immunofluorescence --- immunohistochemistry --- protein --- genome --- biomedical applications --- commercialization --- protein characterization --- conventional approaches --- microfluidic technologies --- single cell --- infectious disease --- pathophysiology --- therapeutics --- diagnostics --- microfluidics --- single-cell cloning --- monoclonal cell lines --- single-neuron models --- mapping --- electrophysiological recording --- isolation --- therapy --- micro/nanofluidic devices --- microelectrode array --- transfection --- artificial intelligence --- localized high-risk prostate cancer --- circulating tumor cells --- three-dimensional (3-D) telomere profiling --- laser microdissection --- whole-exome genome sequencing --- somatic single nucleotide variants --- copy number alterations --- precision medicine --- n/a