Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

Rationale drug design --- GPCR agonists --- Molecular dynamic simulations --- Neurodegenerative Diseases --- monoamine pharmacology --- Oxidative Stress --- Multi-target designed ligands --- Epilepsy --- Chemi-informatics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over 70% of the Earth’s surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.

Medicine --- co-culture --- marine microbes --- natural products --- structural diversity --- biological activities --- food allergy --- deep-sea-derived viridicatol --- X-ray single crystal --- intestinal barrier --- mast cell --- calcium influx --- Chlorella --- enzymes --- lipases --- molecular modeling --- sulfated polysaccharides --- antiviral --- SARS-CoV-2 --- docking --- molecular dynamic simulations --- sea cucumber --- bioactivity --- diversity --- microorganism --- polyketides --- alkaloids --- marine-derived fungus --- Penicillium sp. --- indole-diterpenoids --- cytotoxicity --- antibacterial activity --- Leizhou Peninsula --- mangrove soil --- actinomycetia --- antimicrobial activity --- secondary metabolites --- dereplication --- metabolomics tools --- trioxacarcins --- mansouramycins --- isoquinolinequinones --- marine-derived Streptomyces sp. --- co-culture --- marine microbes --- natural products --- structural diversity --- biological activities --- food allergy --- deep-sea-derived viridicatol --- X-ray single crystal --- intestinal barrier --- mast cell --- calcium influx --- Chlorella --- enzymes --- lipases --- molecular modeling --- sulfated polysaccharides --- antiviral --- SARS-CoV-2 --- docking --- molecular dynamic simulations --- sea cucumber --- bioactivity --- diversity --- microorganism --- polyketides --- alkaloids --- marine-derived fungus --- Penicillium sp. --- indole-diterpenoids --- cytotoxicity --- antibacterial activity --- Leizhou Peninsula --- mangrove soil --- actinomycetia --- antimicrobial activity --- secondary metabolites --- dereplication --- metabolomics tools --- trioxacarcins --- mansouramycins --- isoquinolinequinones --- marine-derived Streptomyces sp.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over 70% of the Earth’s surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.

Medicine --- co-culture --- marine microbes --- natural products --- structural diversity --- biological activities --- food allergy --- deep-sea-derived viridicatol --- X-ray single crystal --- intestinal barrier --- mast cell --- calcium influx --- Chlorella --- enzymes --- lipases --- molecular modeling --- sulfated polysaccharides --- antiviral --- SARS-CoV-2 --- docking --- molecular dynamic simulations --- sea cucumber --- bioactivity --- diversity --- microorganism --- polyketides --- alkaloids --- marine-derived fungus --- Penicillium sp. --- indole-diterpenoids --- cytotoxicity --- antibacterial activity --- Leizhou Peninsula --- mangrove soil --- actinomycetia --- antimicrobial activity --- secondary metabolites --- dereplication --- metabolomics tools --- trioxacarcins --- mansouramycins --- isoquinolinequinones --- marine-derived Streptomyces sp. --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Light alloys (aluminum, magnesium, and titanium alloys) are gaining increasing interest in the scientific and technological community in many different application fields, from automotive to medicine, thanks to their light weight coupled with interesting mechanical properties. The functional performances of light alloys can be significantly affected by their surface properties; in fact, the surface can be considered as the “visiting card” of the material for its working environment (e.g., it can drive the biological response upon implantation for titanium alloys intended for biomedical implants or it can affect the joining ability of aluminum and magnesium alloys) as well as for its further material working steps (e.g., coatings). Surface engineering is a versatile tool for the modification of material surfaces in order to tailor and improve their functional properties. The aim of the present Special Issue is to present the latest development in this field through research and review papers. In particular, the topics of interest include, but are not limited to, surface engineering of light alloys for biomedical applications, surface engineering of light alloys for joining and coatings applications, surface engineering of light alloys for corrosion protection, and surface engineering of light alloys for antibacterial/antifouling purposes.

Mg alloy --- corrosion protection --- hydrothermal synthesis --- coating --- degradable implant --- titanium --- gallic acid --- polyphenols --- surface functionalization --- metal implants --- aluminum alloys --- brazing --- surface preparation --- interface reactions --- joining --- microstructure --- phase/composition in reaction layer --- Ni–P coatings --- Ni3P phase --- Mg alloys --- AZ91 --- heat treatment --- microhardness --- crystallite size --- ion irradiation --- dislocation --- irradiation defect --- microcrystal --- antibacterial activity --- bone growth --- apatite formation --- silver --- strontium --- calcium titanate --- ion release --- cytotoxicity --- controlled release --- biodegradable magnesium --- dopamine --- Impedance behavior --- molecular dynamic simulation --- aluminum oxide layers --- nanostructure --- tribological wear --- surface morphology --- thermo-chemical treatment --- artificial saliva --- lubricant --- zirconia --- titanium alloys --- wear --- n/a --- Ni-P coatings

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Fluid interfaces are promising candidates for confining different types of materials - e.g., polymers, surfactants, colloids, and even small molecules - and for designing new functional materials with reduced dimensionality. The development of such materials requires a deepening of the Physico-chemical bases underlying the formation of layers at fluid interfaces, as well as on the characterization of their structures and properties. This is of particular importance because the constraints associated with the assembly of materials at the interface lead to the emergence of equilibrium and dynamics features in the interfacial systems, which are far from those conventionally found in the traditional materials. This Special Issue is devoted to studies on fundamental and applied aspects of fluid interfaces, trying to provide a comprehensive perspective on the current status of the research field.

Technology: general issues --- thermal radiations --- magnetic field --- Carreau fluid --- stretching/shrinking surface --- Hall effect --- nonlinear radiations --- HAM --- desulfurization wastewater evaporation technology --- evaporation performance --- orthogonal test --- simulation --- spray coating --- coating film formation --- leveling of coating surface --- fluorescence method --- visualization --- ferromagnetic --- nanofluid --- bioconvection --- porous medium --- heat suction/injection --- magnetic dipole --- liquid-infused surfaces --- durability --- lubricants --- wetting --- liquid-repellent coatings --- annealed Co40Fe40W20 thin films --- magnetic tunnel junctions (MTJs) --- X-ray diffraction (XRD) --- contact angle --- surface energy --- nanomechanical properties --- Prandtl nanofluid flow --- convectively heated surface --- stochastic intelligent technique --- Levenberg Marquardt method --- backpropagated network --- artificial neural network --- Adam numerical solver --- surface hydrophilicity --- graphene --- ice formation --- clearance --- molecular dynamic simulation --- dynamics --- fluid interfaces --- inhalation --- lung surfactant --- nanoparticles --- pollutants --- rheology --- emulsion --- droplet size --- microscopy-assisted --- image analysis --- laser diffraction --- turbidity --- viscosity --- Ree-Eyring nanofluid --- viscous dissipation --- Cattaneo-Christov model --- Koo-Kleinstreuer model --- chemical reaction --- heat transfer --- stretching cylinder --- nonlinear radiation --- Powell–Eyring --- Darcy–Forchheimer --- n/a --- Powell-Eyring --- Darcy-Forchheimer