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Glucosinolate-containing foods, such as vegetables from the plant order Brassicales and its derivative products, are valued for their health-beneficial properties. The latter are linked to glucosinolate hydrolysis products, such as isothiocyanates.The book “Advanced Research on Glucosinolates in Food Products” collects the latest research on the impact of the whole food supply chain, including production, as well as domestic food preparation, on glucosinolates and the formation and chemistry of their breakdown products in vegetables and further foods. In this context, the consequences for human health are important, too. The book contains articles that cover research on the effect of pre-harvest factors on glucosinolates, their hydrolyzing enzymes, and the formation of volatile hydrolysis products. Further topics include the linkage between glucosinolates and sensory aspects, and the effects of food preparation and follow-up reactivity. Finally, research on the bioavailability and functional effects of isothiocyanates for human health is included.

pickled vegetables --- yellowing salted radish root --- glucosinolate–myrosinase system --- tryptophan biosynthesis --- isothiocyanates --- glucosinolate --- cabbage --- isothiocyanate --- epithionitrile --- nitrile --- Brassica --- seasonal variation --- food retailer --- glucosinolates --- turnip --- bitter taste --- Brassicaceae --- vegetable --- rucola --- arugula --- Diplotaxis --- Eruca --- flavour --- postharvest --- volatile compounds --- odorants --- ‘salad’ rocket --- wasabi --- horseradish --- watercress --- benzyl isothiocyanate --- protein conjugates --- functional foods --- nasturtium --- garden cress --- thiourea --- plant growth --- protected horticulture --- environmental conditions --- cruciferous vegetables --- gluconasturtiin --- anti-inflammatory --- pro-inflammatory --- physiological-based model --- sulforaphane --- glucoraphanin --- compartmental model --- broccoli --- bioavailability --- myrosinase --- parameter estimation --- Brassica oleracea --- growing condition --- myrosinase activity --- glucosinolate hydrolysis products --- nitriles --- epithionitriles --- myrosinase stability: glucosinolates --- steaming --- microwaving --- stir-frying --- n/a --- glucosinolate-myrosinase system --- 'salad' rocket

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Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.

Research & information: general --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone --- natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone

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Cancer is the second leading cause of death worldwide, and was accountable for an estimated 9.6 million deaths in 2018. Nowadays, about 1 in 6 deaths in the world is due to cancer. Another major global public health issue is HIV. Over 70 million people have been infected with the HIV virus and about 35 million people have died of HIV-related illness, since the start of the epidemic. We have been fighting against these two serious diseases by finding successful treatments. The discovery of effective drugs is important for fighting cancer and HIV. Natural products, which are secondary metabolites produced by various living organisms, have been playing a principal role in drug discovery and developments, because of their structural and biological diversity. Many clinically used drugs have come from natural products; for example, more than 60% of anticancer drugs currently in clinical use are derived from natural sources. This Special Issue aims to collect original research and review articles focusing on notable and recent contributions to the discovery and development of novel anticancer and anti-HIV drug candidates from natural sources. Up-to-date knowledge from various research fields is welcome. This could be of great interest for scientists working in different research areas, such as natural product chemistry, including isolation and structural elucidation; phytochemistry; medicinal chemistry, including chemically modified natural compounds with improved biological activity; pharmacology; molecular biology; mechanisms of action study using natural products or related compounds; pharmacognosy, etc. Biological studies of natural extracts without an appropriate chemical characterization may not be considered.

natural phaeosphaeride A --- antitumor activity --- human tumor cell lines --- HEF cell line --- acute toxicity --- aspidosperma-type --- monoterpenoid indole alkaloids --- antiproliferative activity --- tubulin inhibitor --- Bousigonia mekongensis --- ursolic acid --- DOTA --- triterpenoids --- cytotoxicity --- diterpenoid alkaloids --- human tumor cells --- lipojesaconitine --- delcosine --- delpheline --- kobusine --- pseudokobusine --- BRAF inhibitor --- Mentha aquatica var. Kenting Water Mint --- essential oil --- chemoprevention --- two-stage skin carcinogenesis --- melanoma --- curcumin analog --- apoptosis --- oxidative stress --- drug–drug interaction --- tamoxifen --- taxol --- cisplatin --- Artemisia absinthium L. --- antioxidants --- total phenolic content --- melanoma and breast cancer cell line --- HaCaT cells --- inflammation --- breast cancer --- cell cycle --- flavonoids --- reactive oxygen species --- tumor suppression --- antiretroviral agents --- anti-HIV --- marine metabolites --- natural products --- drug development --- Ivalin --- Carpesium divaricatum --- hepatocellular carcinoma --- mitochondria-mediated apoptosis --- NF-κB --- Hernandia nymphaeifolia --- butanolides --- lignan glycosides --- coumarins --- antiangiogenic --- cancer --- natural agents --- chemistry --- medicine --- cancer stem cell --- cervical cancer --- pterostilbene --- resveratrol --- caffeic acid --- cancer multidrug resistance --- P-glycoprotein --- phenolic acid --- oxypeucedanin --- Angelica dahurica --- antiproliferation --- G2/M phase cell cycle arrest --- p53 --- SK-Hep-1 --- hepatoma cells --- allyl isothiocyanate --- benzyl isothiocyanate --- sulforaphane --- phenethyl isothiocyanate --- bladder cancer --- quercetin --- oral squamous cell carcinoma cells --- metastasis --- cell cycle arrest --- epithelial-to-mesenchymal transition --- matrix metalloproteinase --- transforming growth factor-β1 --- β-lapachone

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Bacterial nanocellulose (BNC), cellulose nanocrystals (CNCs), and cellulose nanofibers (CNFs) are three nanometric forms of the most abundant natural polymer (viz. cellulose), and are currently under the spotlight in numerous fields of modern science and technology. The eco-friendly connotations, peculiar features, and multiple functionalities of these nanoscale cellulosic substrates are being explored to engineer advanced nanocomposites and nanohybrid materials for application in manifold domains, such as mechanics, optics, electronics, energy, environment, biology, and medicine.The aim of this Special Issue titled “Advanced Nanocellulose-Based Materials: Production, Properties, and Applications” is to gather original research and review contributions from the world-leading scientists working with nanocellulose. Thus, research that is representative of the current developments dealing with the production methodologies, properties, and applications of nanocellulose-based materials (e.g., nanocomposites, hybrids, aerogels, hydrogels, films, and fibers) are presented in the Special Issue.

bacterial nanocellulose --- lignosulfonates --- mechanical performance --- thermal-oxidative stability --- ion-exchange membranes --- biobased separators --- ionic conductivity --- oxidized bacterial cellulose --- chitosan --- alginate --- layer-by-layer assembly --- multi-layered patches --- dexpanthenol --- wound healing --- cellulose nanocomposite --- ice-templating --- interface --- orientation --- mechanical properties --- cellulose nanofibrils --- wood --- lignin --- TEMPO-oxidation --- cellulose nanomaterials --- nanoscale resolution --- cellulose --- chitosan nanoparticles --- bionanocomposites --- 5-fluorouracil --- in vitro drug release --- cytotoxicity assay --- colorectal cancer --- lyophilization --- plasma modification --- cell adhesion --- cellulose nanocrystals --- folic acid --- fluorescein isothiocyanate --- nanosystems --- physical adsorption --- cellular uptake --- cellular exometabolomics --- folate receptor-positive cancer cells --- dissolving pulp --- cellulose nanofibril --- nano silicon dioxide --- high strength --- n/a

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This Special Issue presents selected papers from the 8th

stretchable electronic device --- Cu-Ni alloy --- n/a --- bioremediation --- flexible electronic device --- microfluidic device --- tactile sensor --- self-organization --- stretchability --- origami --- flexible device --- pH indicator --- additive manufacturing --- fatigue --- Nafion --- Game of Life --- MEMS --- micropatterns --- stretchable elastomer --- microcantilever --- wearable --- polydimethylsiloxane --- reaction-diffusion system --- capacitive force sensor --- slipping detection --- microfabrication --- alginate hydrogel --- microfluidics --- shape from silhouette --- artificial cochlea --- micro/nano technology --- ion concentration polarization --- thermoelectric generator --- ultraviolet treatment --- micro-stereolithography --- proximity sensor --- blink --- 3D shape reconstruction --- reductive sintering --- cellular automata --- crack configuration --- Young model --- transparent object --- femtosecond laser --- piezoelectric material --- Turing pattern model --- microtubes --- thermoelectric film --- luciferin–luciferase assay --- fluorescein isothiocyanate (FITC) --- printing --- triple-coaxial flow --- photopolymer --- metal conductive track --- ion depletion zone --- sensors --- microbes --- direct writing --- outer hair cell --- dye-sensitized photovoltaic cells --- microfiber spinning --- ATP --- 3D printing --- parasitic capacitance --- luciferin-luciferase assay