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The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.

Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition --- n/a

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Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Capsaicin has been used to treat pain and inflammation associated with a variety of diseases, including rheumatoid arthritis, diabetic neuropathy, post-masectomy pain, cluster headaches, and herpes zoster. Although recent studies have evaluated capsaicin as a novel anti-cancer agent, and mechanisms of capsaicin in preventing cancer have been described sporadically, the literature lacks a comprehensive review of capsaicin as a chemo-preventive agent. Role of Capsaicin in Oxidative Stress and Cancer offers a thorough exploration of the preventive and therapeutic effects of capsaicin in cancer models such as melanoma, pancreatic cancer, colon cancer, gastric cancer, breast cancer, prostate cancer, skin cancer, lung cancer, multiple myeloma and glioma.  The contributors, all internationally recognized researchers, identify various molecular and cellular targets of capsaicin, and show the critical role of mitochondria in capsaicin-mediated therapeutic effects. Readers will learn how capsaicin prevents or may treat cancer, how different cells respond to capsaicin, how environmental carcinogen-induced carcinogenesis can be prevented by capsaicin and the mechanism of oxidative stress caused by capsaicin.  This book will benefit medical students, oncologists and cancer researchers everywhere.

Catechols --- Protective Agents --- Polyunsaturated Alkamides --- Solanaceous Alkaloids --- Diseases --- Therapeutic Uses --- Fatty Acids, Monounsaturated --- Stress, Physiological --- Metabolism --- Fatty Acids, Unsaturated --- Physiological Processes --- Metabolic Phenomena --- Amides --- Alkaloids --- Physiological Effects of Drugs --- Phenols --- Alkenes --- Pharmacologic Actions --- Specialty Uses of Chemicals --- Heterocyclic Compounds --- Chemical Actions and Uses --- Phenomena and Processes --- Organic Chemicals --- Fatty Acids --- Physiological Phenomena --- Hydrocarbons, Acyclic --- Lipids --- Chemicals and Drugs --- Hydrocarbons --- Neoplasms --- Capsaicin --- Antineoplastic Agents --- Oxidative Stress --- Anticarcinogenic Agents --- Medicine --- Health & Biological Sciences --- Oncology --- Capsaicin. --- Oxidative stress. --- Axsain (Trademark) --- Capsaicine --- Capsidol (Trademark) --- Capsin (Trademark) --- Capzasin (Trademark) --- Gelcen (Trademark) --- Katrum (Trademark) --- NGX-4010 (Trademark) --- Qutenza (Trademark) --- Zacin (Trademark) --- Zostrix (Trademark) --- Medicine. --- Science. --- Cancer research. --- Gene expression. --- Pharmacology. --- Cell biology. --- Apoptosis. --- Biomedicine. --- Cancer Research. --- Science, general. --- Pharmacology/Toxicology. --- Gene Expression. --- Cell Biology. --- Oxidation-reduction reaction --- Stress (Physiology) --- Analgesics --- Capsaicinoids --- Oncology. --- Cytology. --- Toxicology. --- Science, Humanities and Social Sciences, multidisciplinary. --- Genes --- Genetic regulation --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Expression --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cell death --- Cancer research --- Physiological effect

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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol --- Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol

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• Reference Manager
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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol