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Retinoids --- Rétinoïdes --- Retinoids. --- 615.27 --- Agents affecting metabolism and cell functions --- 615.27 Agents affecting metabolism and cell functions --- Rétinoïdes --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein

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In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop­ mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re­ cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper­ imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.

Retinoids --- Physiological effect. --- Therapeutic use. --- Therapeutic use --- Physiological effect --- Pharmacology. --- Biochemistry. --- Molecular biology. --- Cancer research. --- Dermatology. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Molecular Medicine. --- Cancer Research. --- Medicine --- Skin --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Diseases --- Composition --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein

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Dermatologic agents --- Etretinate --- Isotretinoin --- Retinoids --- Skin --- Skin diseases --- Vitamin A --- SKIN DISEASES, drug therapy --- VITAMIN A, analogs and derivates --- VITAMIN A, therapeutic use --- Congresses. --- Testing --- Therapeutic use --- Diseases --- Chemotherapy --- Drug therapy --- Analogs & derivatives --- Skin diseases, drug therapy --- Vitamin a, analogs and derivates --- Vitamin a, therapeutic use --- Vitamin a --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein --- Accutane (Trademark) --- Cis-retinoic acid --- Retinoic acid, Cis --- -Tretinoin --- Tretinoin --- Drugs, Dermatologic --- Dermatopharmacology --- Congresses --- Testing&delete& --- Therapeutic use&delete& --- Diseases&delete& --- Chemotherapy&delete&

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This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the importance of consuming vitamins throughout human history, but empirical studies of their physiological role and mode of action only began about 150 years ago. Since then, the biochemical nature of vitamin A and its active derivative, retinoic acid, have been identified and researchers around the globe have investigated retinoic acid’s physiological function in growth processes and in maintaining life Written by leading experts, this book discusses the latest findings and advances in retinoic acid research. It addresses topics such as the role of retinoic acid signaling in a multitude of processes, including limb, heart and respiratory system development, as well as its role in maintaining postnatal organ systems. This book is a valuable resource for scientists involved in vitamin A/retinoic acid research and readers interested in developmental biology.

Human physiology. --- Nutrition   . --- Embryology. --- Physiology. --- Human Physiology. --- Nutrition. --- Animal physiology --- Animals --- Biology --- Anatomy --- Animal embryology --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Human biology --- Medical sciences --- Human body --- Embryology --- Development --- Health aspects --- Cellular signal transduction. --- Retinoids. --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Retinoides --- Vitamina A --- Embriologia --- Fisiologia humana --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Retinol --- Vitamina antixeroftàlmica --- Vitamines liposolubles --- Carotenoides