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The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.

Tissues --- Nervous System Physiological Processes --- Nervous System --- Nervous System Physiological Phenomena --- Anatomy --- Musculoskeletal and Neural Physiological Phenomena --- Phenomena and Processes --- Neuronal Plasticity --- Nerve Tissue --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Anatomies --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous Systems --- System, Nervous --- Systems, Nervous --- Tissue --- Nervous Tissue --- Nerve Tissues --- Nervous Tissues --- Tissue, Nerve --- Tissue, Nervous --- Tissues, Nerve --- Tissues, Nervous --- Axon Pruning --- Axonal Pruning --- Dendrite Arborization --- Dendrite Pruning --- Dendritic Arborization --- Dendritic Pruning --- Dendritic Remodeling --- Neural Plasticity --- Neurite Pruning --- Neuronal Arborization --- Neuronal Network Remodeling --- Neuronal Pruning --- Neuronal Remodeling --- Neuroplasticity --- Synaptic Plasticity --- Synaptic Pruning --- Plasticity, Neuronal --- Arborization, Dendrite --- Arborization, Dendritic --- Arborization, Neuronal --- Arborizations, Dendrite --- Arborizations, Dendritic --- Arborizations, Neuronal --- Axon Prunings --- Axonal Prunings --- Dendrite Arborizations --- Dendrite Prunings --- Dendritic Arborizations --- Dendritic Prunings --- Dendritic Remodelings --- Network Remodeling, Neuronal --- Network Remodelings, Neuronal --- Neural Plasticities --- Neurite Prunings --- Neuronal Arborizations --- Neuronal Network Remodelings --- Neuronal Plasticities --- Neuronal Prunings --- Neuronal Remodelings --- Neuroplasticities --- Plasticities, Neural --- Plasticities, Neuronal --- Plasticities, Synaptic --- Plasticity, Neural --- Plasticity, Synaptic --- Pruning, Axon --- Pruning, Axonal --- Pruning, Dendrite --- Pruning, Dendritic --- Pruning, Neurite --- Pruning, Neuronal --- Pruning, Synaptic --- Prunings, Axon --- Prunings, Axonal --- Prunings, Dendrite --- Prunings, Dendritic --- Prunings, Neurite --- Prunings, Neuronal --- Prunings, Synaptic --- Remodeling, Dendritic --- Remodeling, Neuronal --- Remodeling, Neuronal Network --- Remodelings, Dendritic --- Remodelings, Neuronal --- Remodelings, Neuronal Network --- Synaptic Plasticities --- Synaptic Prunings --- physiology --- Cell Plasticity --- Brain Plasticity --- Brain Plasticities --- Plasticities, Brain --- Plasticity, Brain --- Neuroplasticity. --- Neurochemistry. --- Biochemistry --- Neurosciences --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology