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This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.
Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Pathology. --- Pharmacology/Toxicology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic
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This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Agents teratògens. --- Embriologia --- Manuals de laboratori --- Tècniques de laboratori --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Factors teratògens --- Medicaments teratògens --- Teratògens
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This book reviews normal thymic structure and covers the histomorphology of benign and malignant tumors and rare lesions of the thymus, with detailed descriptions of over 300 full color photomicrographs accompanied by relevant clinical and radiology photographs and anatomical drawings. It includes chapters on the surgical pathology and cytology of thymic lesions (which is rarely described in the available literature), and all grades and stages of the most common thymic lesions. Written and edited by leading experts on pathology, the book highlights the expanded role of pathologists in patient care for thymic lesions. It will help students to understand thymic cytology and surgical pathology in detail and enable them to answer questions on thymic surgical resections and cytology cases in their pathology post-graduation examination. In addition, the book offers a comprehensive, richly illustrated guide to thymic pathology for clinicians, practicing pathologists, post-graduate residents and students alike.
Pathology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Thymus --- Tumors --- Thymus gland --- Endocrine glands --- Lymphoid tissue --- Quistos --- Patologia --- 650 --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Colesteatoma --- Equinococcosi
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Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Placenta. --- Mammals --- Reproduction. --- Cotyledon (Anatomy) --- Embryology --- Uterus, Pregnant
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Stem cells. --- Veterinary embryology. --- Embryology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cèl·lules mare embrionàries --- Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Cèl·lules mare
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This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.
Pathology. --- Hematology. --- Oncology . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Medul·la òssia --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Sistema immunitari --- Trastorns mieloproliferatius
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This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems. .
Pathology. --- Oncology . --- Surgery. --- Oncology. --- Surgery, Primitive --- Medicine --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Breast Neoplasms --- pathology. --- Breast --- Diagnosis. --- Mama --- Càncer de mama --- Biòpsia --- Patologia --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Xoc --- Anatomia patològica --- Diagnòstic --- Cirurgia operatòria --- Biòpsia per aspiració --- Càncer de pit --- Càncer --- Malalties de la mama --- Càncer ginecològic --- Mames --- Mamella --- Mamelles --- Pit --- Pits --- Sines --- Glàndules mamàries --- Alletament --- Llet materna
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This volume is a practical resource for the diagnosis and multi-disciplinary management of patients with vascular anomalies. Although designed by and for hematologists and oncologists, this text also assists clinicians in many specialties with appropriate nomenclature, diagnosis, and management of the heterogeneous disorders considered as vascular anomalies, including kaposiform hemangioendothelioma, capillary malformations, venous malformations, lymphatic anomalies, and arteriovenous malformation. The book features full-color clinical photographs and diagnostic imaging to enrich descriptions of these conditions and to ensure accurate diagnosis for appropriate management recommendations. Written by experts in their fields, Vascular Anomalies: A Guide for the Hematologist/Oncologistis a valuable resource for clinicians treating and researchers studying patients with vascular anomalies.
Hematology. --- Oncology . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Diseases --- Hematology, Oncology. --- Malalties vasculars --- Malformacions --- Hematologia --- Oncologia --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Medicina interna --- Hematologia pediàtrica --- Malalties hematològiques --- Anomalies (Medicina) --- Anomalies congènites --- Anomalies del desenvolupament --- Anomalies humanes --- Defectes congènits --- Defectes de naixement --- Deformacions (Medicina) --- Deformitats congènites --- Irregularitats congènites --- Lesions congènites --- Malformacions congènites --- Malformacions humanes --- Morfologia (Biologia) --- Teratologia --- Patologia --- Malformacions de la boca --- Malformacions de la columna vertebral --- Malformacions del cor --- Malformacions del fetus --- Malformacions del peu --- Malformacions en els animals --- Angiologia --- Malalties dels vasos sanguinis --- Aneurismes --- Insuficiència venosa --- Malaltia de Raynaud --- Malalties cerebrovasculars --- Vasculitis --- Cardiologia
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This book covers neoplastic and non-neoplastic pulmonary diseases, supplying essential information for the most common pulmonary diseases as well as many of the rarer ones. Organized around disease entities and presented in outline form, this book provides easy access to the essential facts and is illustrated with plentiful figures. The essential pathology, radiology and bronchoscopic technologies are discussed, as well as the tools needed to facilitate the most specific diagnoses and thus the most appropriate therapies. Each chapter also provides a list of suggested readings to guide further study. Written for a broad audience of clinicians who encounter these diseases in their everyday practice, this book serves specialists in pulmonary medicine and internal medicine, as well as general surgical pathologists who encounter these diseases as pulmonary specimens and who use this information for definitive evaluation and diagnoses of these entities, especially in small biopsies and cytopathology specimens. Pulmonary Disease: Pathology, Radiology, Bronchoscopy brings together the essential clinical, radiologic and pathologic insights for the major diseases of the lung, emphasizing the diagnostic criteria needed to ensure accurate diagnoses from small specimens.
Pathology. --- Respiratory organs—Diseases. --- Pneumology/Respiratory System. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Lungs --- Diagnosis. --- Malalties dels pulmons --- Patologia --- Radiologia --- Broncoscòpia --- Endoscòpia --- Física radiològica --- Física --- Radiografia --- Radiació --- Patologia humana --- Medicina --- Bacteriologia --- Càlculs --- Degeneració (Patologia) --- Diagnòstic de laboratori --- Estenosi --- Etiologia --- Genètica mèdica --- Glucòlisi --- Hipertròfia --- Histopatologia --- Hèrnia --- Immunopatologia --- Inflamació --- Insuficiència sistèmica --- Malformacions --- Metàstasi --- Paleopatologia --- Patologia cel·lular --- Patologia veterinària --- Teratologia --- Tumors --- Xoc --- Anatomia patològica --- Diagnòstic --- Malalties pulmonars --- Pneumopaties --- Bronquitis --- Displàsia broncopulmonar --- Fibrosi pulmonar --- Fibrosi quística --- Insuficiència respiratòria --- Legionel·losi --- Malalties pulmonars obstructives cròniques --- Pneumònia --- Pneumotòrax --- Malalties del pulmó
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Head --- Face --- Abnormalities. --- Dysmorphism, Facial --- Facial dysmorphism --- Abnormities and deformities --- Malformacions --- Cara --- Cap --- Malformacions de l'articulació temporomandibular --- Anomalies maxil·lofacials --- Malformacions del maxil·lar --- Malformacions maxil·lomandibulars --- Cos humà --- Cabells --- Cervell --- Frenologia --- Maxil·lars --- Orella --- Ull --- Encèfal --- Crani --- Fesomia --- Fisonomia --- Rostre --- Boca --- Mentó --- Nas --- Fisiognomonia --- Anomalies (Medicina) --- Anomalies congènites --- Anomalies del desenvolupament --- Anomalies humanes --- Defectes congènits --- Defectes de naixement --- Deformacions (Medicina) --- Deformitats congènites --- Irregularitats congènites --- Lesions congènites --- Malformacions congènites --- Malformacions humanes --- Morfologia (Biologia) --- Teratologia --- Patologia --- Malformacions de la boca --- Malformacions de la columna vertebral --- Malformacions del cor --- Malformacions del fetus --- Malformacions del peu --- Malformacions en els animals
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