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This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.

Medicine --- chronic rhinosinusitis --- B-cell lymphoproliferative disorder --- sinus --- nasal allergies --- tannery worker --- Kanpur --- asthma --- ovalbumin --- saffron --- salbutamol --- IL’s --- TNF-α --- allergic rhinitis --- bronchial asthma --- allergy --- Th17 cells --- IL-17 --- IL-33 --- microRNA --- miR --- airway mucosal inflammation --- united airway disease --- acute rhinosinusitis --- acute recurrent rhinosinusitis --- Mediterranean diet --- nutritional evaluation --- nutritional therapy --- olfactory dysfunction --- anosmia --- post-acute COVID-19 --- nitric oxide --- NO --- exhaled NO --- FENO --- nasal peak flow --- atopic status --- total IgE --- specific IgE --- childhood asthma --- immunoblot --- ImmunoCAP --- otolaryngology --- sinusitis --- ethnic groups --- patient-reported outcome measures --- quality of life --- social justice --- n/a --- IL's

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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment

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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

History of engineering & technology --- sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-α capture --- human articular chondrocytes --- rheumatoid arthritis --- microfluidic chip --- live assay --- hepatocellular carcinoma cells --- PLA95 --- guided tissue regeneration (GTR) --- electrospun fiber mats --- mechanobiology --- glioblastoma --- finite element modeling --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

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This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment

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Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.

hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing