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Post-weaning social isolation of rats produces psychological and physiological changes that are relevant to schizophrenia. Here, we report that long-term potentiation (LTP) in the CA1 to subiculum pathway is lower by 34%, (P<0.0001) in brain slices from isolates compared with those from socially housed rats. We also report that LTP in this pathway is NMDA receptor-dependent. (C) 2003 Elsevier B.V. All rights reserved

Abnormalities. --- Acoustic startle. --- Brain. --- Ca1. --- Cognitive impairment. --- Expression. --- Hippocampal-formation. --- Isolation. --- Long-term potentiation. --- Long-term. --- Ltp. --- Nmda receptor. --- Nucleus-accumbens. --- Physiological. --- Post weaning. --- Potentiation. --- Prepulse inhibition. --- Projections. --- Rat. --- Rats. --- Schizophrenia. --- Slices. --- Social isolation. --- Social-isolation. --- Social. --- Subfields. --- Subiculum. --- Time.

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Hippocampus (Brain) --- Hippocampe (Cerveau) --- Périodiques. --- Ammon's horn --- Cornu ammonis --- Cerebral cortex --- Limbic system --- Hippocampus --- Ammon's Horn --- Hippocampus Proper --- Schaffer Collaterals --- Ammon Horn --- Cornu Ammonis --- Hippocampal Formation --- Subiculum --- Ammons Horn --- Collaterals, Schaffer --- Formation, Hippocampal --- Formations, Hippocampal --- Hippocampal Formations --- Hippocampus Propers --- Horn, Ammon --- Horn, Ammon's --- Proper, Hippocampus --- Propers, Hippocampus --- Subiculums --- Entorhinal Cortex --- Perforant Pathway --- Schaffer Collateral --- Collateral, Schaffer --- Hippocampus. --- Periodicals.

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It is well established that epigenetic factors influence the maturation of neurotransmitter systems. Social isolation as well as an early intervention with methamphetamine (MA) lead to a diminished maturation of dopaminergic (DA) fibres in cortical and striatal areas in the brain of Mongolian gerbils. The aim of this study was to prove whether isolated rearing (IR) and the application of a single dose of MA on postnatal day 14 affect the maturation of DA fibres in caudal limbic areas. Therefore the DA fibre densities were quantified in the dorsolateral and ventrolateral entorhinal cortex (EC), the ventral subiculum (SUB) and in three amygdala nuclei - the basolateral (BLA), the lateral (LA) and the central (CA) nucleus. Our results showed that IR and an early MA application led to an increase of DA fibre densities in various caudal limbic areas. Whereas the BLA was affected by both IR and MA, the LA and the medial left CA were only influenced by MA in IR animals. The DA fibre surplus in the ventrolateral EC was significant in MA treated ER and IR animals in the left and right hemisphere, respectively. The SUB and the dorsolateral EC remained unaffected by both epigenetic factors. Altogether, the BLA seems to be the area which responds most sensitively to IR and MA. Previous studies in our laboratory showed a suppressive maturation of DA fibres in the prefrontal cortex (PFC) and nucleus accumbens (NAC) induced by the same set of epigenetic factors. Thus, due to the close functional connection between the PFC and limbic areas, it could be assumed that the suppressive maturation of prefrontal DA fibres implicates an enhancement of DA innervation densities in caudal limbic areas. Imbalances in the morphology and physiology of the different DA projections are suggested here to be crucial in the aetiology of schizophrenia

6-hydroxydopamine lesions. --- Accumbens. --- Amygdala. --- Animal. --- Animals. --- Application. --- Area. --- Basolateral amygdala neurons. --- Brain. --- Caudal limbic areas. --- Cortex. --- Density. --- Dopamine. --- Enhancement. --- Entorhinal cortex. --- Fibre overshoot. --- Gerbil. --- Gerbils. --- Hemisphere. --- Hippocampal-formation. --- Increase. --- Isolation. --- Laboratory. --- Maturation. --- Medial prefrontal cortex. --- Meriones unguiculatus. --- Meriones-unguiculatus. --- Methamphetamine. --- Mongolian gerbil. --- Mongolian gerbils. --- Mongolian-gerbil. --- Morphology. --- Neurotransmitter systems. --- Nucleus accumbens. --- Nucleus-accumbens-septi. --- Nucleus-accumbens. --- Nucleus. --- Physiology. --- Postnatal-development. --- Prefrontal cortex. --- Projections. --- Rat cerebral-cortex. --- Rearing. --- Schizophrenia. --- Social isolation. --- Social-isolation. --- Social. --- Subiculum. --- System. --- Systems. --- Time. --- Unguiculatus. --- Ventral tegmental area.

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Neural circuitry. --- Oscillations. --- Cerebral cortex. --- Hippocampus (Brain) --- Réseaux nerveux --- Oscillations --- Cortex cérébral --- Hippocampe (Cerveau) --- Neural circuitry --- Cerebral cortex --- Electroencephalography Phase Synchronization --- Neurons --- Limbic System --- Cerebrum --- Cortical Synchronization --- Pyramidal Cells --- Hippocampus --- Interneurons --- Cerebral Cortex --- Nervous System --- Telencephalon --- Cells --- Electroencephalography --- Brain --- Electrophysiological Processes --- Diagnostic Techniques, Neurological --- Electrodiagnosis --- Anatomy --- Electrophysiological Phenomena --- Prosencephalon --- Central Nervous System --- Diagnostic Techniques and Procedures --- Physiological Phenomena --- Diagnosis --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Human Anatomy & Physiology --- Neuroscience --- Health & Biological Sciences --- Réseaux nerveux --- Cortex cérébral --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Cerebrospinal Axis --- Axi, Cerebrospinal --- Axis, Cerebrospinal --- Central Nervous Systems --- Cerebrospinal Axi --- Nervous System, Central --- Nervous Systems, Central --- System, Central Nervous --- Systems, Central Nervous --- Forebrain --- Forebrains --- Electrophysiologic Concepts --- Electrophysiologic Phenomena --- Electrophysiological Phenomenon --- Electrophysiological Process --- Electrophysiological Concepts --- Concept, Electrophysiologic --- Concept, Electrophysiological --- Concepts, Electrophysiologic --- Concepts, Electrophysiological --- Electrophysiologic Concept --- Electrophysiological Concept --- Phenomena, Electrophysiologic --- Phenomena, Electrophysiological --- Phenomenon, Electrophysiological --- Process, Electrophysiological --- Processes, Electrophysiological --- Anatomies --- Electrodiagnoses --- Diagnostic Technic, Neurological --- Diagnostic Technics, Neurologic --- Diagnostic Technics, Neurological --- Diagnostic Technique, Neurological --- Diagnostic Techniques, Neurologic --- Neurological Diagnostic Technic --- Neurological Diagnostic Technics --- Neurological Diagnostic Technique --- Neurological Diagnostic Techniques --- Technic, Neurological Diagnostic --- Technics, Neurological Diagnostic --- Technique, Neurological Diagnostic --- Techniques, Neurological Diagnostic --- Diagnostic Technic, Neurologic --- Diagnostic Technique, Neurologic --- Neurologic Diagnostic Technic --- Neurologic Diagnostic Technics --- Neurologic Diagnostic Technique --- Neurologic Diagnostic Techniques --- Technic, Neurologic Diagnostic --- Technics, Neurologic Diagnostic --- Technique, Neurologic Diagnostic --- Techniques, Neurologic Diagnostic --- Encephalon --- Brains --- Encephalons --- Electroencephalogram --- EEG --- Electroencephalograms --- Cell --- Endbrain --- Endbrains --- Nervous Systems --- System, Nervous --- Systems, Nervous --- Allocortex --- Archipallium --- Cortex Cerebri --- Cortical Plate --- Insular Cortex --- Paleocortex --- Periallocortex --- Insula of Reil --- Allocortices --- Archipalliums --- Cerebral Cortices --- Cerebri, Cortex --- Cerebrus, Cortex --- Cortex Cerebrus --- Cortex, Cerebral --- Cortex, Insular --- Cortical Plates --- Cortices, Cerebral --- Cortices, Insular --- Insular Cortices --- Paleocortices --- Periallocortices --- Plate, Cortical --- Plates, Cortical --- Reil Insula --- Intercalated Neurons --- Intercalated Neuron --- Interneuron --- Neuron, Intercalated --- Neurons, Intercalated --- Ammon's Horn --- Hippocampus Proper --- Schaffer Collaterals --- Ammon Horn --- Cornu Ammonis --- Hippocampal Formation --- Subiculum --- Ammons Horn --- Collaterals, Schaffer --- Formation, Hippocampal --- Formations, Hippocampal --- Hippocampal Formations --- Hippocampus Propers --- Horn, Ammon --- Horn, Ammon's --- Proper, Hippocampus --- Propers, Hippocampus --- Subiculums --- Limbic Systems --- System, Limbic --- Systems, Limbic --- Pyramidal Neurons --- Cell, Pyramidal --- Cells, Pyramidal --- Neuron, Pyramidal --- Neurons, Pyramidal --- Pyramidal Cell --- Pyramidal Neuron --- Cortical Phase Desynchronization --- Cortical Phase Synchronization --- Cortical Desynchronization --- Cortical Desynchronizations --- Cortical Phase Desynchronizations --- Cortical Phase Synchronizations --- Cortical Synchronizations --- Desynchronization, Cortical --- Desynchronizations, Cortical --- Phase Desynchronization, Cortical --- Phase Desynchronizations, Cortical --- Phase Synchronization, Cortical --- Phase Synchronizations, Cortical --- Synchronization, Cortical --- Synchronizations, Cortical --- Cerebral Hemispheres --- Left Cerebral Hemisphere --- Right Cerebral Hemisphere --- Cerebral Hemisphere --- Cerebral Hemisphere, Left --- Cerebral Hemisphere, Right --- Nerve Cells --- Cell, Nerve --- Cells, Nerve --- Nerve Cell --- Neuron --- Ammon's horn --- Cornu ammonis --- Brain mantle --- Cortex cerebri --- Mantle of brain --- Pallium (Brain) --- Circuitry, Neural --- Circuits, Neural --- Nerve net --- Nerve network --- Neural circuits --- Neurocircuitry --- Neuronal circuitry --- diagnosis --- methods --- EEG Phase Desynchrony --- EEG Phase Synchrony --- Electroencephalography Phase Desynchrony --- Electroencephalography Phase Synchrony --- Phase Desynchrony, EEG --- Phase Synchrony, EEG --- EEG Phase Desynchronization --- EEG Phase Synchronization --- Electroencephalography Phase Desynchronization --- Phase Desynchronization, EEG --- Phase Synchronization, EEG --- Desynchronies, EEG Phase --- Desynchronies, Electroencephalography Phase --- Desynchronization, EEG Phase --- Desynchronization, Electroencephalography Phase --- Desynchronizations, EEG Phase --- Desynchronizations, Electroencephalography Phase --- Desynchrony, EEG Phase --- Desynchrony, Electroencephalography Phase --- EEG Phase Desynchronies --- EEG Phase Desynchronizations --- EEG Phase Synchronies --- EEG Phase Synchronizations --- Electroencephalography Phase Desynchronies --- Electroencephalography Phase Desynchronizations --- Electroencephalography Phase Synchronies --- Electroencephalography Phase Synchronizations --- Phase Desynchronies, EEG --- Phase Desynchronies, Electroencephalography --- Phase Desynchronization, Electroencephalography --- Phase Desynchronizations, EEG --- Phase Desynchronizations, Electroencephalography --- Phase Desynchrony, Electroencephalography --- Phase Synchronies, EEG --- Phase Synchronies, Electroencephalography --- Phase Synchronization, Electroencephalography --- Phase Synchronizations, EEG --- Phase Synchronizations, Electroencephalography --- Phase Synchrony, Electroencephalography --- Synchronies, EEG Phase --- Synchronies, Electroencephalography Phase --- Synchronization, EEG Phase --- Synchronization, Electroencephalography Phase --- Synchronizations, EEG Phase --- Synchronizations, Electroencephalography Phase --- Synchrony, EEG Phase --- Synchrony, Electroencephalography Phase --- Sensitivity and Specificity --- Cell Biology --- Entorhinal Cortex --- Perforant Pathway --- CA1 Region, Hippocampal --- CA2 Region, Hippocampal --- CA3 Region, Hippocampal --- Evoked Potentials --- Limbic system --- Cycles --- Fluctuations (Physics) --- Vibration --- Electrophysiology --- Nervous system --- Neural networks (Neurobiology) --- Reflexes --- NEUROSCIENCE/General