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Et si la vieillesse était une maladie et qu'on pouvait en guérir ? C'est ce défi un peu fou que l'auteur a choisi de relever. Avec son équipe de recherche, Jean-Marc Lemaitre a réussi à rajeunir des cellules en les reprogrammant dans le but de régénérer nos organes vieillissants. L'application de ses découvertes sur la souris donne déjà des résultats sidérants. Celles qui sont traitées vivent 30 % plus longtemps que les autres et sont en meilleure forme, intellectuelle comme physique. Le chercheur français le plus en pointe dans le domaine raconte les tout derniers progrès de la science pour ralentir, voire inverser le cours du vieillissement. Des avancées prodigieuses qui permettront demain d'allonger l'espérance de vie en bonne santé pour tous et de rester jeune plus longtemps. Enfin une bonne nouvelle !
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Cellular and nuclear reprogramming - Ectoderm specification and differentiation - Endoderm specification and differentiation - Epigenetics - Genomics and proteomics - Germ cell and somatic stem cell biology in reproduction - Mesoderm specification and differentiation - Niche biology, homing, and migration - Renewal - Stem cell immunology - Therapeutic prospects - Tissue engineering.
Stem cells --- Stem Cell Research. --- Research. --- Life Sciences --- Biology
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Cellular and nuclear reprogramming - Ectoderm specification and differentiation - Endoderm specification and differentiation - Epigenetics - Genomics and proteomics - Germ cell and somatic stem cell biology in reproduction - Mesoderm specification and differentiation - Niche biology, homing, and migration - Renewal - Stem cell immunology - Therapeutic prospects - Tissue engineering.
Stem cells --- Stem Cell Research. --- Stem cells --- Research. --- Research.
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Cellular and nuclear reprogramming - Ectoderm specification and differentiation - Endoderm specification and differentiation - Epigenetics - Genomics and proteomics - Germ cell and somatic stem cell biology in reproduction - Mesoderm specification and differentiation - Niche biology, homing, and migration - Renewal - Stem cell immunology - Therapeutic prospects - Tissue engineering.
Stem cells --- Stem Cell Research. --- Stem cells --- Research. --- Research.
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Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: ""Isolation and Characterization"" and ""Clinical Perspectives and Applications."" In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.
Stem cells --- Research. --- Life Sciences --- Genetics and Molecular Biology --- Biochemistry --- Stem Cell Research --- Cell Biology
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"Preface: the first volume of Stem cells deals with the fundamental principles that govern embryonic and somatic stem cell biology. Historically, the identification and characterization of such pathways and general rules of stemness occurred during embryonic development and volume I reflects this with topics spanning from cell cycle regulation, epigenetics, and asymmetric cell division in a number of organ systems from planarian to human. Three specific sections will discuss( i) Basic stem cell biology, (ii) Tissue formation during development, and (iii) Model organisms with particular emphasis on those more relevant for biomedical research and, thus, leading to the topics addressed in volume II"
Embryonic Stem Cells --- Stem Cell Research --- Stem Cells --- metabolism. --- ethics. --- metabolism.
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Umbilical cord blood (UCB) and, more recently, umbilical cord tissue (UCT) have been stored cryopreserved in private and public cord blood and tissue banks worldwide, since the umbilical cord blood was used for the first time in a child with Fanconi anemia with his HLA-identical sibling, following strict guidelines that imply high-quality standards and total rastreability of these units. The hematopoietic stem cells (HSCs) are clinically used in hematopoietic treatments for blood disorders and hemato-oncological diseases. Also, the mesenchymal stem cells (MSCs) isolated from the UCT and UCB, nowadays, can be used as coadjuvants of hematopoietic transplants. In the near future, these stem cells will have a crucial role in regenerative medicine. For this reason, these cells have been tested in several clinical trials and compassive treatments in children and adults, concerning a wide range of pathologies and diseases, for instance, for the treatment of cerebral paralysis. Considering the worldwide availability of UCB and UCT units and the absence of ethical concerns will probably become the best sources for cell-based therapies for hematological and nonhematological pathologies. The UCB will also have a crucial role in neonatology-predictive analysis in the near future.
Fetal blood --- Analysis. --- Cord blood --- Umbilical cord blood --- Blood --- Medicine --- Stem Cell Research --- Health Sciences --- Cell Biology
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Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.
Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Medicine --- Stem Cell Research --- Health Sciences --- Cell Biology
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Stem cells --- Developmental neurobiology. --- Neural Stem Cells. --- Neurogenesis. --- Stem Cells --- Stem Cell Research --- Therapeutic use. --- physiology. --- ethics.
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Computational Biology. --- Medical Informatics. --- Stem Cell Research. --- Stem Cells. --- Neoplastic Stem Cells. --- Computer Simulation. --- Machine learning. --- Regenerative medicine.
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