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Human physiology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Human biochemistry --- Pathological biochemistry --- Pathological haematology --- Blood proteins --- Plasma proteins --- Serum proteins --- Blood plasma --- Proteins --- Serum

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Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspec-tive. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory cir-cuits. In this respect, scientists from around the world convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 5–10, 2005), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the "novel" functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Complement (Immunology) --- Blood proteins. --- Plasma proteins --- Serum proteins --- Blood plasma --- Proteins --- Serum --- Alexin --- Complements (Immunity) --- Blood proteins --- Immunology. --- Microbiology. --- Emerging infectious diseases. --- Pathology. --- Infectious Diseases. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Microbial biology --- Biology --- Microorganisms --- Immunobiology --- Life sciences --- Serology --- Infectious diseases.

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Pathological biochemistry --- Pathological haematology --- Blood Proteins. --- Blood Protein Disorders --- Blood Protein Electrophoresis. --- Blood Protein Electrophoreses --- Electrophoreses, Blood Protein --- Electrophoresis, Blood Protein --- Protein Electrophoreses, Blood --- Protein Electrophoresis, Blood --- Immunoelectrophoresis --- Plasma Proteins --- Serum Proteins --- Proteins, Blood --- Proteins, Plasma --- Proteins, Serum --- Proteins --- physiopathology. --- blood --- Blood proteins --- BLOOD PROTEIN DISORDERS --- BLOOD PROTEIN ELECTROPHORESIS --- physiopathology --- Blood proteins. --- BLOOD PROTEIN ELECTROPHORESIS. --- Blood protein disorders --- Blood protein electrophoresis. --- Physiopathology. --- Hemoglobin Electrophoresis --- Electrophoresis, Hemoglobin --- Blood Protein --- Plasma Protein --- Serum Protein --- Protein, Blood --- Protein, Plasma --- Protein, Serum --- Blood Proteins --- Blood Protein Electrophoresis

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There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the clinical research into TTR. Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies. The evolution of transthyretin has been extensively investigated – from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships. This monograph will bring the reader up to date on the latest developments and discoveries.

Carrier proteins. --- Cerebrospinal fluid proteins. --- Thyroid hormones. --- Thyroxine. --- Cerebrospinal fluid proteins --- Thyroxine --- Carrier proteins --- Thyroid hormones --- Evolution, Molecular --- Multiprotein Complexes --- Prealbumin --- Amyloidosis --- Macromolecular Substances --- Biological Evolution --- Serum Albumin --- Proteostasis Deficiencies --- Chemicals and Drugs --- Metabolic Diseases --- Biological Processes --- Genetic Processes --- Blood Proteins --- Albumins --- Nutritional and Metabolic Diseases --- Proteins --- Biological Phenomena --- Genetic Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Diseases --- Physiology --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Blood proteins --- Liver --- Metabolism. --- Secretions. --- Plasma proteins --- Serum proteins --- Medicine. --- Human physiology. --- Endocrinology. --- Proteomics. --- Biomedicine. --- Human Physiology. --- Abdomen --- Biliary tract --- Blood plasma --- Serum --- Human biology --- Medical sciences --- Human body --- Molecular biology --- Internal medicine --- Hormones --- Endocrinology .

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Viruses have properties that are distinct from other living organisms and so require different methods to culture them. This volume provides a broad treatment of the principles and practice of virus culture.

Plant Viruses --- Antibodies, Monoclonal --- Virus Cultivation --- Antiviral Agents --- Microscopy, Electron --- Viral Vaccines --- Virology --- Viruses --- Antibodies --- Microbiological Techniques --- Microscopy --- Microbiology --- Anti-Infective Agents --- Vaccines --- Immunoglobulins --- Biological Products --- Biology --- Therapeutic Uses --- Diagnostic Imaging --- Investigative Techniques --- Organisms --- Clinical Laboratory Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Serum Globulins --- Complex Mixtures --- Immunoproteins --- Biological Science Disciplines --- Diagnostic Techniques and Procedures --- Pharmacologic Actions --- Globulins --- Blood Proteins --- Diagnosis --- Chemicals and Drugs --- Natural Science Disciplines --- Chemical Actions and Uses --- Proteins --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Microbiology & Immunology --- Health & Biological Sciences --- Gene Products, Protein --- Gene Proteins --- Protein --- Protein Gene Products --- Proteins, Gene --- Molecular Mechanisms of Pharmacological Action --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Diagnose --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Blood Protein --- Plasma Protein --- Plasma Proteins --- Serum Protein --- Serum Proteins --- Protein, Blood --- Protein, Plasma --- Protein, Serum --- Proteins, Blood --- Proteins, Plasma --- Proteins, Serum --- Globulin --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Diagnostic Testing --- Testing, Diagnostic --- Sensitivity and Specificity --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Complex Extract --- Complex Mixture --- Crude Extract --- Mixtures, Complex --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- Euglobulins --- Pseudoglobulins --- Globulins, Serum --- Clinical Laboratory Diagnoses --- Clinical Laboratory Testings --- Clinical Laboratory Tests --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Clinical Laboratory Test --- Clinical Laboratory Testing --- Diagnose, Clinical Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Laboratory Test, Clinical --- Laboratory Testing, Clinical --- Technique, Clinical Laboratory --- Test, Clinical Laboratory --- Testing, Clinical Laboratory --- Laboratories --- Medical Laboratory Science --- Clinical Laboratory Services --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Imaging, Diagnostic --- Imaging, Medical --- Medical Imaging --- Radiologic and Imaging Nursing --- Image Processing, Computer-Assisted --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biologics --- Biopharmaceutical --- Natural Product --- Natural Products --- Drug, Biologic --- Drug, Biological --- Drugs, Biologic --- Drugs, Biological --- Medicine, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Product, Biologic --- Product, Biological --- Product, Natural --- Biological Factors --- Immunoglobulin --- Globulins, Immune --- Immune Globulin --- Immune Globulins --- Globulin, Immune --- Genes, Immunoglobulin --- Vaccine --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Microbicides --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agent --- Anti Infective Agents --- Anti Microbial Agent --- Anti Microbial Agents --- Infections --- Parasites --- Infectious Disease Medicine --- Compound Microscopy --- Hand-Held Microscopy --- Light Microscopy --- Optical Microscopy --- Simple Microscopy --- Hand Held Microscopy --- Microscopy, Compound --- Microscopy, Hand-Held --- Microscopy, Light --- Microscopy, Optical --- Microscopy, Simple --- Microbiologic Technic --- Microbiologic Technics --- Microbiologic Technique --- Microbiological Technics --- Technic, Microbiologic --- Technics, Microbiological --- Technique, Microbiologic --- Techniques, Microbiologic --- Microbiologic Techniques --- Microbiological Technic --- Microbiological Technique --- Technic, Microbiological --- Technics, Microbiologic --- Technique, Microbiological --- Techniques, Microbiological --- Animal Viruses --- Zoophaginae --- Animal Virus --- Virus --- Virus, Animal --- Viruses, Animal --- Genetic Vectors --- Viral Vaccine --- Vaccine, Viral --- Vaccines, Viral --- Electron Microscopy --- Antiviral Drugs --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Antivirals --- Agent, Antiviral --- Agents, Antiviral --- Drug, Antiviral --- Drugs, Antiviral --- Interferon Inducers --- Virus Diseases --- Virus Inactivation --- Viral Cultivation --- Cultivation, Viral --- Cultivation, Virus --- Cultivations, Viral --- Cultivations, Virus --- Viral Cultivations --- Virus Cultivations --- Culture Techniques --- Monoclonal Antibodies --- Monoclonal Antibody --- Antibody, Monoclonal --- Hybridomas --- Phytophagineae --- Plant Virus --- Virus, Plant --- Viruses, Plant --- diagnosis --- blood --- methods --- Virus Cultivation. --- Virologie --- Cultures and culture media --- Cultures et milieux de culture --- Organelles --- Occupations --- Cultures and culture media.