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This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC.

Squamous cell carcinoma. --- SCC (Oncology) --- Squamous cell cancer --- Cancer --- Oncology

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Cellule d'épithéliome spinocellulaire --- Epithelioomcel spinocellulare --- Epithéliome spinocellulaire [Cellule d' ] --- SCC (Oncology) --- Squamous cell cancer --- Squamous cell carcinoma --- Anus --- Cancer

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apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol­ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book. I would also like to express my thanks to Ron Landes, Cynthia Conomos, Sara Lord and all the other members of the Landes Bioscience staff for their expertise, diligence and patience in helping me complete this work. Jorg Reichrathy Prof, Dn med. CHAPTER 1 The Epidemiology of Basal Cell and Squamous Cell Carcinoma Hao Wang and Thomas L.

Skin --- Basal cell carcinoma --- Squamous cell carcinoma --- Cancer --- Genetic aspects. --- SCC (Oncology) --- Squamous cell cancer --- Basal cell cancer --- Basal cell epithelioma --- Epithelioma, Basal cell --- Foot cell carcinoma --- Rodent ulcer --- Oncology. --- Oncology  . --- Pathology. --- Cancer Research. --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Cancer research. --- Cancer research

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Squamous cell carcinoma of the esophagus has a lower incidence than other gastrointestinal tract cancer; however, there are many difficult issued related to the choice of appropriate therapy for these patients. In recent years, the use of multimodal treatment has greatly improved the prognosis of patients affected by this disease but several aspects of the oncological and surgical management are still controversial. This book aims to give a homogeneous approach to esophageal cancer treatment, based on the author’s lifetime experience in conjunction with exhaustive review of recent literature. In each chapter surgeons and oncologists will find appropriate tools for correct management of the diagnosis and therapy of this difficult disease. The book analyzes all the aspects of staging and treatment, such as modern diagnostic and staging techniques (MRI or PET-CT), endoscopic treatment of early cancer, new minimally invasive and open surgical techniques, and combined treatment. In addition, there are chapters dedicated to the postoperative course of these patients, as well as their quality of life, with indications for the correct follow-up and treatment of relapses.

Cancer -- Radiotherapy -- Examinations, questions, etc. --- Neoplasms -- radiotherapy -- Examination Questions. --- Esophagus --- Squamous cell carcinoma --- Gastrointestinal system --- Pharyngeal Neoplasms --- Carcinoma --- Gastrointestinal Neoplasms --- Head and Neck Neoplasms --- Esophageal Diseases --- Neoplasms, Squamous Cell --- Digestive System Neoplasms --- Neoplasms, Glandular and Epithelial --- Otorhinolaryngologic Neoplasms --- Gastrointestinal Diseases --- Pharyngeal Diseases --- Neoplasms by Site --- Digestive System Diseases --- Neoplasms by Histologic Type --- Stomatognathic Diseases --- Otorhinolaryngologic Diseases --- Neoplasms --- Diseases --- Hypopharyngeal Neoplasms --- Carcinoma, Squamous Cell --- Esophageal Neoplasms --- Medicine --- Surgery & Anesthesiology --- Health & Biological Sciences --- Oncology --- Surgery - General and By Type --- Treatment --- Cancer --- Hypopharynx --- Squamous cell carcinoma. --- Cancer. --- SCC (Oncology) --- Squamous cell cancer --- Medicine. --- Radiotherapy. --- Gastroenterology. --- Oncology. --- Surgery. --- Medicine & Public Health. --- Surgery, Primitive --- Tumors --- Internal medicine --- Digestive organs --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Radiological services --- Oncology  . --- Gastroenterology .