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The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.

red blood cells --- n/a --- metastatic potential --- microfluidic devices --- microstructure --- lens-less --- regression analysis --- power-law fluid --- narrow rectangular microchannel --- biomedical coatings --- XTC-YF cells --- red blood cell (RBC) aggregation --- Y-27632 --- finite element method --- POCT --- CEA detection --- immersed boundary method --- suspension --- particle tracking velocimetry --- biomicrofluidics --- computational fluid dynamics --- red blood cells (RBCs) --- modified conventional erythrocyte sedimentation rate (ESR) method --- computational biomechanics --- RBC aggregation index --- microfabrication --- microfluidics --- morphological analysis --- chronic renal disease --- multiple microfluidic channels --- centrifugal microfluidic device --- deformability --- master molder using xurography technique --- fluorescent chemiluminescence --- hydrophobic dish --- pressure-driven flow --- cell deformability --- mechanophenotyping --- separation and sorting techniques --- density medium --- cell adhesion --- polymers --- rheology --- circular microchannel --- blood on chips --- multinucleated cells --- velocity --- cell analysis --- microfluidic chip --- twin-image removal --- cancer --- Lattice–Boltzmann method --- diabetes --- hyperbolic microchannel --- Lattice-Boltzmann method

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The development of micro- and nanodevices for blood analysis continues to be a growing interdisciplinary subject that demands the careful integration of different research fields. Following the success of the book “Micro/Nano Devices for Blood Analysis”, we invited more authors from the scientific community to participate in and submit their research for a second volume. Researchers from different areas and backgrounds cooperated actively and submitted high-quality research, focusing on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis; micro- and nanofluidics; technologies for flow visualization and diagnosis; biochips, organ-on-a-chip and lab-on-a-chip devices; and their applications to research and industry.

blood viscosity --- Erythrocyte sedimentation rate (ESR) --- T-shaped microfluidic channel --- air-compressed syringe (ACS) --- micro-particle image velocimetry --- viscoelasticity --- microfluidic device --- coflowing streams --- interface --- linear differential equation --- two approximate factors --- dielectrophoresis --- electrophysiological properties --- crossover frequency --- wake or recirculation formation --- dielectric spectra --- air compliance effect --- RBC aggregation --- blood viscoelasticity --- blood velocity fields --- interface in co-flowing streams --- blood flow --- particle tracking --- red blood cells --- manual methods --- automatic methods --- image analysis --- biomicrofluidics --- microfluidics --- blood plasma filtration --- chip extract --- blood molecules --- patient-derived organoids --- colorectal cancer --- 3D model --- drug screening --- diagnostics --- malaria --- optical filters --- reflectance --- spectrophotometry --- TFCalc --- small caliber blood vessel --- composite molding --- micro-nano structure --- tissue repair --- 3D printing --- blood cells --- fourier transform infrared (FTIR) spectroscopy --- functional group --- lab-on-a-chip --- n/a