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The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells. They are also the major histocompatibilty barriers to transplantation, which is the clinical paradigm of the self versus non self concept. It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to be important in many aspects of clinical practice. As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, and immunogenetic laboratories specializing in these methods have developed to support transplantation and other clinical programs. Immunogenetics: Methods and Applications in Clinical Practice focuses on methods for human clinical practice. The emphasis rests on those assays which are of established or potential clinical utility and are likely to be included in the repertoire of tests provided by a routine diagnostic and service laboratory. This volume also contains several review chapters of the MHC complex, the KIR complex, the human immunoglobulin allotypes, as well as reviews of the methods for the detection of alloreactive NK cells and the detection of HLA antibodies by solid phase assays.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, Immunogenetics: Methods and Applications in Clinical Practice seeks to serve both the immunogenetics community  and the wider scientific community with a collection of detailed information and helpful tips attained by many years of experience in the field.

Immunogenetics --- Investigative Techniques --- Immune System Phenomena --- Biology --- Publication Formats --- Transplantation Immunology --- Phenomena and Processes --- Immune System Processes --- Biological Science Disciplines --- Publication Characteristics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Genetics --- Immunogenetic Phenomena --- Immunologic Techniques --- Histocompatibility --- Methods --- Laboratory Manuals --- Immunity --- Health & Biological Sciences --- Microbiology & Immunology --- Biophysics --- Immunogénétique --- Immunité --- Histocompatibilité --- Immunogenetic Phenomena. --- Méthodes --- Génétique --- methods --- genetics --- Disease --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Immunocompatibility --- Tissue Compatibility --- Compatibilities, Tissue --- Compatibility, Tissue --- Histocompatibilities --- Immunocompatibilities --- Tissue Compatibilities --- Immunogenetic --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- Immunogenetic Phenomenon --- Immunogenetic Concepts --- Immunogenetic Processes --- Concept, Immunogenetic --- Concepts, Immunogenetic --- Immunogenetic Concept --- Phenomena, Immunogenetic --- Phenomenon, Immunogenetic --- Processes, Immunogenetic --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Immunology, Transplantation --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Immunology --- immunology --- Immunological aspects --- Genetic aspects --- Medicine. --- Human genetics. --- Immunology. --- Biomedicine. --- Human Genetics. --- Immunobiology --- Life sciences --- Serology --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Medical sciences --- Pathology --- Physicians --- Immunologic Techniques. --- methods. --- genetics. --- Méthodes. --- Génétique.