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PHY Physiology & Biochemistry --- oxigen deficiency --- physiology
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This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. One section of the book is also dedicated to the therapeutics in ROS-induced cancer. It discusses the ways to interfere with the cancer progression, and design anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and the current perspectives about therapeutics of cancers. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology. .
Cancer research. --- Genetics. --- Cancer Research. --- Genetics and Genomics. --- Estrès oxidatiu --- Càncer --- Oxigen actiu
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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Cardiology. --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Heart --- Internal medicine --- Diseases --- Oxigen actiu --- Ús terapèutic --- Farmacologia --- Pharmacology. --- Clinical biochemistry. --- Neuroscience. --- Medical Biochemistry. --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Aplicacions mèdiques --- Aplicacions terapèutiques --- Ús en medecina --- Medicina alternativa --- Terapèutica --- Anions superòxid --- Oxigen reactiu --- Radicals d'oxigen --- Oxigen --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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This volume provides a varied selection of current methods and molecular probes used to generate, image and quantify ROS production and lipid peroxidation. Chapters guide readers through methods and protocols on in silico modelling of ROS dynamics in biological systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Reactive Oxygen Species: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Oxigen actiu --- Metabolisme --- Anabolisme --- Catabolisme --- Biologia --- Bioquímica --- Cicle de Krebs --- Gliconeogènesi --- Metabolisme basal --- Metabolisme cel·lular --- Metabolisme de les plantes --- Metabolisme dels lípids --- Metabolisme energètic --- Metabolisme microbià --- Metabolisme mineral --- Metabolisme secundari --- Urea --- Biosíntesi --- Nutrició --- Respiració --- Anions superòxid --- Oxigen reactiu --- Radicals d'oxigen --- Oxigen --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Química biològica --- Química fisiològica --- Medicina --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica
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This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.
Active oxygen --- Cancer. --- Oxidative stress. --- Physiological effect. --- Oxidation-reduction reaction --- Stress (Physiology) --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Medicine --- Biology --- Cytology. --- Medical genetics. --- Human physiology. --- Biotechnology. --- Biomedical Research. --- Cell Biology. --- Medical Genetics. --- Human Physiology. --- Research. --- Chemical engineering --- Genetic engineering --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Pathology --- Genetic disorders --- Cell biology --- Cellular biology --- Cells --- Biological research --- Biomedical research --- Health Workforce --- Genetic aspects --- Estrès oxidatiu --- Càncer --- Oxigen actiu --- Efectes fisiològics
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This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editors’ extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series. The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.
Proteins . --- Biochemistry. --- Protein Science. --- Biochemistry, general. --- Proteins --- Vertebrates. --- Body fluids. --- Lipoproteins. --- Invertebrates. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Composition --- Invertebrata --- Animals --- Lipids --- Animal fluids and humors --- Body humors --- Fluids, Body --- Fluids and humors, Animal --- Humors, Body --- Vertebrata --- Chordata --- Proteïnes --- Oxigen en l'organisme --- Composició del cos humà --- Oximetria --- Anoxèmia --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica
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This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Medicine. --- Biomedicine, general. --- Health Workforce --- Oxygen --- Tissue respiration --- Physiological transport --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Chalcogens --- Nonmetals --- Photosynthetic oxygen evolution --- Oxigen en l'organisme --- Teixits (Histologia) --- Fisiologia humana --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Teixits (Biologia) --- Teixits animals --- Teixits humans --- Teixits orgànics --- Cèl·lules i teixits vegetals --- Cultiu de teixits --- Epiteli --- Músculs --- Periodonci --- Teixit nerviós --- Teixit connectiu --- Cèl·lules animals --- Histologia --- Empelts de teixits --- Òrgans (Anatomia) --- Composició del cos humà --- Oximetria --- Anoxèmia --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Oxygen,
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Biology --- Free Radicals --- Medicine --- Oxidation-Reduction --- Oxidative Stress --- Peroxidases --- Free radicals (Chemistry) --- Oxidation, Physiological --- Radicaux libres (Chimie) --- Oxydation biologique --- Periodicals. --- periodicals. --- Pathophysiology --- Periodicals --- Physiopathologie --- Périodiques --- Biology. --- Free Radicals. --- Medicine. --- Oxidation-Reduction. --- Oxidative Stress. --- Peroxidases. --- Oxidation, Physiological. --- Pathophysiology. --- Health Sciences --- Life Sciences --- Pathology --- free radicals --- oxidative stress --- activated oxygen --- redox processes --- perioxidative processes --- Ovoperoxidase --- Stress, Oxidative --- Oxidative Stresses --- Stresses, Oxidative --- Nitrosative Stress --- Antioxidants --- Reactive Oxygen Species --- Redox --- Oxidation Reduction --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Radicals, Free --- Free Radical Scavengers --- Biological oxidation --- Oxidation, Biological --- Physiological oxidation --- Biochemistry --- Radicals (Chemistry) --- Free radical reactions --- Health Workforce --- Anti-oxidative Stress --- Antioxidative Stress --- DNA Oxidative Damage --- Nitro-Oxidative Stress --- Oxidative Cleavage --- Oxidative DNA Damage --- Oxidative Damage --- Oxidative Injury --- Oxidative Nitrative Stress --- Oxidative Stress Injury --- Oxidative and Nitrosative Stress --- Anti oxidative Stress --- Anti-oxidative Stresses --- Antioxidative Stresses --- Cleavage, Oxidative --- DNA Damage, Oxidative --- DNA Oxidative Damages --- Damage, DNA Oxidative --- Damage, Oxidative --- Damage, Oxidative DNA --- Injury, Oxidative --- Injury, Oxidative Stress --- Nitrative Stress, Oxidative --- Nitro Oxidative Stress --- Nitro-Oxidative Stresses --- Oxidative Cleavages --- Oxidative DNA Damages --- Oxidative Damage, DNA --- Oxidative Damages --- Oxidative Injuries --- Oxidative Nitrative Stresses --- Oxidative Stress Injuries --- Stress Injury, Oxidative --- Stress, Anti-oxidative --- Stress, Antioxidative --- Stress, Nitro-Oxidative --- Stress, Oxidative Nitrative --- Stresses, Nitro-Oxidative --- Free Radical --- Radical, Free --- Radicals lliures (Química) --- Reacció d'oxidació-reducció --- Oxigen --- Reacció d'oxidació-reducció. --- Oxigen.
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