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This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Agents teratògens. --- Embriologia --- Manuals de laboratori --- Tècniques de laboratori --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Factors teratògens --- Medicaments teratògens --- Teratògens

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Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Placenta. --- Mammals --- Reproduction. --- Cotyledon (Anatomy) --- Embryology --- Uterus, Pregnant

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Physiology of nerves and sense organs --- Neurology --- Nervous System --- Nervous system --- Neurologie --- Système nerveux --- growth & development --- Periodicals --- Growth --- Périodiques --- Croissance --- Neurology. --- growth & development. --- Growth. --- nervous system --- neural circuits --- neural regeneration --- Medicine --- Neuropsychiatry --- Developmental neurobiology --- Organs (Anatomy) --- Neurosciences --- Diseases --- Neuropathology --- Neurologia. --- Neurobiologia del desenvolupament. --- Desenvolupament del sistema nerviós --- Desenvolupament neurològic --- Diferenciació neurològica --- Neurogènesi --- Neurologia del desenvolupament --- Biologia del desenvolupament --- Embriologia --- Neurobiologia --- Organogènesi --- Neuroplasticitat --- Medicina --- Electrofisiologia --- Inhibició --- Neurocirurgia --- Neurooftalmologia --- Neuroimmunologia --- Neurologia pediàtrica --- Neurologia geriàtrica --- Neurologia veterinària --- Psicofisiologia --- Psicopatologia --- Urgències en neurologia --- Neuròlegs

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Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.

Human genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Animal models in research. --- Animal genetics. --- Human Genetics. --- Animal Models. --- Animal Genetics and Genomics. --- Animal experimentation --- Biological models --- Laboratory animals --- Research --- Drosòfila --- Oftalmopaties --- Organogènesi --- Formació d'òrgans --- Organogènia --- Morfogènesi --- Neurobiologia del desenvolupament --- Malalties de l'ull --- Malalties dels ulls --- Malalties oculars --- Malalties --- Cataractes --- Conjuntivitis --- Infeccions oculars --- Manifestacions oculars de les malalties --- Oftàlmia --- Síndrome de Sjögren --- Trastorns de la visió --- Ull --- Drosophila --- Drosofílids --- Drosòfila melanogaster --- Drosòfila subobscura

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This volume explores the latest techniques and improved methods used to study important neurobiological and associated neuropathological conditions. Chapters cover topics such as the application of semiconductor quantum dots as photostable fluorophores used for labeling and tracking; GCaMP6 transcranial imaging to monitor neural activity; the patch-clamping technique allowing simultaneous monitoring of membrane currents and optical signals; and quantifying behavioral dysfunction caused by traumatic brain injury (TBI). In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Basic Neurobiology Techniques is a valuable resource for novel and expert researchers interested in expanding their knowledge of this developing field. .

Neurobiology --- Neurosciences --- Methodology. --- Neurobiologia --- Metodologia de la ciència --- Manuals de laboratori --- Tècniques de laboratori --- Mètode científic --- Metodologia científica --- Lògica matemàtica --- Metodologia --- Classificació de les ciències --- Estereologia --- Mètodes experimentals --- Observació (Mètode científic) --- Qüestionament --- Lògica --- Treball de camp --- Biologia del sistema nerviós --- Biologia --- Neurociències --- Neuroanatomia --- Neurobiologia del desenvolupament --- Neurobiologia molecular --- Neurofisiologia --- Xarxes neuronals (Neurobiologia) --- Neurosciences. --- Neuroscience. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Creativitat en la ciència