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Paediatrics --- prematuriteit --- neonatale-intensieve-zorgen afdeling --- neonatologie --- couveuse --- prematuriteit (preterme geboorte, vroeggeboorte) --- perinatale sterfte --- neonatale intensieve zorgen afdeling (neonatal intensive care unit, NICU) --- 605.2

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temperatuur --- gastro-enterologie --- Child nursing --- CPR (Cardiopulmonale Resuscitatie) --- intensieve zorgen --- intensieve-zorgen afdeling --- traumatologie --- neurologie --- pneumologie --- kinderverpleegkunde --- pijn --- farmacologie --- cardiologie --- endocrinologie --- aangeboren afwijkingen --- Paediatrics --- pediatrie --- pediatrische verpleegkunde --- 605.2 --- 616.083.3 --- Intensieve zorgen --- NICU --- PICU --- 616.084 )* INTENSIEVE ZORGEN --- CPR --- ademhaling --- basisverpleegkunde --- centraal zenuwstelsel --- circulatiestelsel --- immunologie --- intensieve zorgen afdeling --- kindererpleegkunde --- 613.61 --- geneesmiddelentoediening --- intensieve zorgen (medium care) --- kinderverpleegkunde (pediatrische verpleegkunde) --- patiëntenvervoer --- reanimatie --- Pediatrie --- Verpleegkunde --- Intensive care --- Kinderen --- verpleegkundige opleiding --- kindergeneeskunde --- intensive care --- Intensieve zorgen en spoedgevallenzorg --- intensive-care --- PHL-Healthcare 13 --- Intensieve-zorgen afdeling --- Intensieve zorgafdeling --- Kind --- Jeugd --- Media --- Ontwikkelingsstoornis --- Fysiotherapie

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This issue of Children concerns healthcare delivery and research in neonatology. Several articles concern the work of the California Perinatal Quality Care Collaborative, including a history by founder Dr. Jeffrey Gould, and recent quality improvement work. Other articles concern methodological issues in neonatal research and findings of recent clinical studies.

NICU --- perinatal care --- California --- wildfire --- disaster preparedness --- evacuation --- very low birthweight infant --- nasal respiratory support --- s-NIPPV --- NCPAP --- intermittent hypoxia --- neonatal monitoring --- respiratory rate --- clinical alarms --- video recording --- biomedical technology --- collaborative quality improvement --- perinatal healthcare --- neonatology --- neonatal simulation --- simulation --- debriefing --- quality improvement --- collaborative --- neonatal intensive care unit --- in-situ simulation --- patient safety --- body temperature --- hypothermia --- hyperthermia --- neonates --- term --- preterm --- postnatal transition --- oxygenation --- tissue oxygenation --- near-infrared spectroscopy --- infants --- infant --- neonatal intensive care --- health service research --- statistics --- study interpretation --- health care costs --- quality --- value --- neonatal resuscitation

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This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

donor breast milk --- human milk --- milk analysis --- very low birth weight --- preterm --- growth --- preterm infant --- donor human milk --- formula feeding --- breastfeeding --- necrotizing enterocolitis --- breast milk --- prematurity --- immunity --- newborn --- inflammation --- colostrum administration --- premature neonates --- clinical outcomes --- intestinal resection --- short bowel syndrome --- intestinal adaptation --- microbiome --- parenteral nutrition --- hormones --- milk fat globule --- long chain polyunsaturated fatty acids --- premature infants --- neonatal --- intestine --- glycosaminoglycans --- intestinal inflammation --- bioactive --- donor milk --- gastroschisis --- intestinal atresia --- human milk fortifier --- patient empowerment --- neonatal nutrition --- communication --- product labeling --- NICU parent --- extracellular vesicle --- exosome --- immature intestine --- formula --- osmolality --- breastmilk --- late onset sepsis --- bloodstream infections --- enteric pathogens --- human milk banks --- NEC --- meta-analysis --- breast-feeding --- spontaneous intestinal perforation --- feeding --- nutrition

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The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.

Medicine --- dasatinib --- Duchenne muscular dystrophy --- cyclodextrin inclusion complex --- phase solubility studies --- paediatric age --- liquid formulation --- tumorspheres --- retinoblastoma --- topotecan --- penetration --- confocal microscopy --- poorly water soluble drug --- solubility enhancement --- grinding --- spray congealing --- neglected tropical diseases --- polymorph --- Norvir® --- ritonavir --- poorly soluble compound --- pediatric --- palatability assessment --- bioavailability --- flavor profile --- Interleukin-1 --- anakinra --- canakinumab --- innovative biotechnologies --- autoinflammatory disease --- Kawasaki disease --- systemic juvenile idiopathic arthritis --- personalized medicine --- child --- pediatrics --- neonates --- formulation --- product development --- formulation development --- oral --- parenteral --- topical --- inhaled --- intra nasal --- biopharmaceutics --- administration --- excipient --- NICU --- device --- medication error --- dosage form --- modified release --- drug delivery --- paediatric formulation development --- paediatric dosage forms --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- pediatric age --- imatinib --- nilotinb --- ponatinib --- Orodispersible formulation --- pyrazinamide --- pediatric drug delivery --- tuberculosis --- design of experiments --- children --- edible films --- development --- design --- paediatric --- age-related --- palatable --- taste-masking --- acceptable --- dasatinib --- Duchenne muscular dystrophy --- cyclodextrin inclusion complex --- phase solubility studies --- paediatric age --- liquid formulation --- tumorspheres --- retinoblastoma --- topotecan --- penetration --- confocal microscopy --- poorly water soluble drug --- solubility enhancement --- grinding --- spray congealing --- neglected tropical diseases --- polymorph --- Norvir® --- ritonavir --- poorly soluble compound --- pediatric --- palatability assessment --- bioavailability --- flavor profile --- Interleukin-1 --- anakinra --- canakinumab --- innovative biotechnologies --- autoinflammatory disease --- Kawasaki disease --- systemic juvenile idiopathic arthritis --- personalized medicine --- child --- pediatrics --- neonates --- formulation --- product development --- formulation development --- oral --- parenteral --- topical --- inhaled --- intra nasal --- biopharmaceutics --- administration --- excipient --- NICU --- device --- medication error --- dosage form --- modified release --- drug delivery --- paediatric formulation development --- paediatric dosage forms --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- pediatric age --- imatinib --- nilotinb --- ponatinib --- Orodispersible formulation --- pyrazinamide --- pediatric drug delivery --- tuberculosis --- design of experiments --- children --- edible films --- development --- design --- paediatric --- age-related --- palatable --- taste-masking --- acceptable