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LYMPHOPROLIFERATIVE DISORDERS --- LYMPHOPROLIFERATIVE DISORDERS

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This highly illustrated, diagnostic guidebook provides a single comprehensive source of essential information to enable non-specialists to diagnose lymph node and related diseases with confidence. The text is didactic and practical, covering reactive as well as malignant conditions. Diagnosis of Lymphoproliferative Diseases approaches the disorders based on the WHO classification and is edited by members of the WHO panel for the classification of lymphomas. This second edition contains over 1000 high quality, digitised colour images and tables of essential criteria for each diagnosis. New features include:* Full discussion of immunostaining, the core of modern diagnosis* Variant forms and technical issues This authoritative guide is an essential reference for haematologists, haematopathologists, general pathologists, diagnostic histopathologists and oncologists.

Lymphoproliferative Disorders --- Lymphoproliferative disorders --- Syndromes lymphoprolifératifs --- diagnosis --- Diagnosis. --- Diagnostic

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Since the first liver transplants, improving immunosuppressive therapy and reducing the incidence of acute rejection have saved many lives. However, some patients develop de novo cancer after liver transplantations, the most commons are skin cancer and post-transplant lymphoproliferative disorder. Their incidence is higher in transplant patients than in the general population. The occurrence of de novo cancer depends on the risk factors to which patients are exposed. A major risk factor is immunosuppression. The stronger the immunosuppression , the greater the risk of developing de novo cancer. Minimizing immunosuppression has a great interest in the medical field which is to reduce the risk of de novo cancer becoming a major cause of mortality in transplant recipients. Other immunosuppressive medications with anti-tumor activity will be introduced in the future to address this important issue . Depuis les premières transplantations hépatiques, l'amélioration des traitements immunosuppresseurs et la réduction de l'incidence des rejets aigus ont permis de sauver beaucoup de vies. Cependant , certains patients développent un cancer de novo après la transplantation hépatique, les plus courants sont le cancer cutané et le syndrome lymphoprolifératif post-transplantation. Leur incidence est beaucoup plus élevée chez les patients transplantés que dans la population générale. L'appar ition du cancer de novo dépend des facteurs de risques auxquels sont exposés les patients. Un des facteurs de risques majeur est l'immunosuppression . Plus fort est l'immunosuppression , plus grand est le risque de développer un cancer de novo. Minimiser l'immunosupp resion a un grand interêt dans le domaine médical, il s'agit de diminuer le risque de cancer de novo devenu une cause importante de mortalié chez les receveurs transplantés. D'autres médications immunosuppresives ayant une activité anti-tumorale seront introduites dans le futur pour faire face à ce problème important.

Liver Transplantation --- Skin Neoplasms --- Lymphoproliferative Disorders

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Lymphoproliferative disorders - Cytopathology. --- Hematopoietic system - Cancer - Cytopathology.

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Amyloid protein aggregates are involved in ''protein-misfolding diseases'' of enormous social and economic impact, still with no effective therapies. The most prevalent amyloid pathologies are related to neurodegenerative diseases, but amyloidosis also affects other organs. The majority of the studies includes serious health connotations on amyloids. However, not all amyloid fibers play a detrimental role in host. An increasing number of studies shows an important beneficial role as ''functional amyloids''. This book opens an exciting door to provide up-to-date information about the function and the mechanisms of the amyloid formation process from the structural, biophysical, biomedical, and nanotechnological perspective, combining the new findings on toxic and functional amyloids studies using theoretical and experimental approaches to fight against amyloid-based diseases.

Amyloidosis. --- Amyloid degeneration --- Lymphoproliferative disorders --- Proteins --- Metabolism --- Disorders --- Cardiovascular medicine