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Iron is essential for most forms of life, including humans. On the other hand, iron is also potentially toxic. Therefore, the control of iron metabolism and maintenance of iron hemostasis is an crucial part of many aspects of human health and disease. Iron deficiency anemia is one of the most common diseases worldwide, but there are also anemias associated with chronic diseases, and other acquired or hereditary defects. Understanding the control of iron metabolism is furthermore important for understanding diseases of iron overload, like hemochromatosis. This booklet is designed for physicians, clinical lab personnel and medical students. It gives an overview about the principles of regulation of iron metabolism and erythropoiesis. In addition, the various disturbances of iron metabolism and the associated clinical findings are described. Special focus lies on the differential diagnosis of the disorders, and the approaches of therapy. Finally, a comprehensive schedule of tests is included available for the determination of iron metabolism-related parameters in serum/plasma and blood, with indication of methodologies applied and reference ranges.

Anemia. --- Erythropoiesis -- physiology. --- Iron -- Metabolism -- Laboratory manuals. --- Iron -- Metabolism. --- Iron Metabolism Disorders. --- Iron --- Anemia --- Metabolic Diseases --- Hematopoiesis --- Hematologic Diseases --- Metabolic Phenomena --- Metals, Heavy --- Biological Science Disciplines --- Transition Elements --- Natural Science Disciplines --- Hemic and Lymphatic Diseases --- Phenomena and Processes --- Nutritional and Metabolic Diseases --- Elements --- Blood Physiological Processes --- Cell Differentiation --- Metals --- Blood Physiological Phenomena --- Inorganic Chemicals --- Disciplines and Occupations --- Diseases --- Cell Physiological Processes --- Chemicals and Drugs --- Cell Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Erythropoiesis --- Physiology --- Iron Metabolism Disorders --- Metabolism --- Medicine --- Health & Biological Sciences --- Pathology --- Disorder --- Metabolic Phenomenon --- Metabolic Process --- Metabolism Concepts --- Metabolism Phenomena --- Process, Metabolic --- Processes, Metabolic --- Anabolism --- Catabolism --- Metabolic Concepts --- Metabolic Processes --- Concept, Metabolic --- Concept, Metabolism --- Concepts, Metabolic --- Concepts, Metabolism --- Metabolic Concept --- Metabolism Concept --- Phenomena, Metabolic --- Phenomena, Metabolism --- Phenomenon, Metabolic --- Disorder, Iron Metabolism --- Disorders, Iron Metabolism --- Iron Metabolism Disorder --- Metabolism Disorder, Iron --- Metabolism Disorders, Iron --- Anemias --- Erythropoieses --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Chemicals, Inorganic --- Blood Physiological Concepts --- Blood Physiological Phenomenon --- Physiology, Blood --- Blood Physiologic Processes --- Blood Physiology --- Blood Physiological Concept --- Blood Physiological Phenomenas --- Concept, Blood Physiological --- Concepts, Blood Physiological --- Phenomena, Blood Physiological --- Phenomenon, Blood Physiological --- Physiologic Processes, Blood --- Physiological Concept, Blood --- Physiological Concepts, Blood --- Physiological Phenomenon, Blood --- Processes, Blood Physiologic --- Processes, Blood Physiological --- Blood --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Elements, Transition --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Heavy Metals --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Haematopoiesis --- Hematopoiesis, Medullary --- Medullary Hematopoiesis --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Anaemia --- Circulatory and Respiratory Physiological Phenomenon --- Physiology, Circulatory and Respiratory --- Circulatory and Respiratory Physiology --- physiology --- Medicine. --- Hematology. --- Metabolic diseases. --- Nephrology. --- Rheumatology. --- Medicine & Public Health. --- Metabolic Diseases. --- Internal medicine --- Connective tissues --- Joints --- Kidneys --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Haematology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Disorders.