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Evidence based medicine is at the core of modern medicine. It involves the integration of individual clinical expertise with the best available clinical evidence from systematic research and patient's values and expectations. Systematic reviews offer a summary of the best available evidence. They are the most reliable and comprehensive statement about what works. Written by clinical academics from Australia, UK, USA, and Switzerland, this contributed volume introduces the readers to the principles and practice of systematic reviews and meta-analysis. It covers the various steps involved in systematic reviews including development of a focused question and the strategy for conducting a comprehensive literature search, identifying studies addressing the underlying question, assessment of heterogeneity and the risk of bias in the included studies, data extraction, and the approach to meta-analysis. Crucial issues such as selecting the model for meta-analysis, generating and interpreting forest plots, assessing the risk of publication bias, cautions in the interpretation of subgroup and sensitivity analyses, rating certainty of the evidence using GRADE guideline, and standardized reporting of meta-analysis (PRISMA) are covered in detail. Every attempt is made to keep the narrative simple and clear. Mathematical formulae are avoided as much as possible. While the focus of this book is on systematic reviews and meta-analyses of randomised controlled trials (RCTs), the gold standard of clinical research, the essentials of systematic reviews of non-RCTs, diagnostic test accuracy studies, animal studies, individual participant data meta-analysis, and network meta-analysis are also covered. Readers from all faculties of medicine will enjoy this comprehensive and reader friendly book to understand the principles and practice of systematic reviews and meta-analysis for guiding their clinical practice and research.

Systematic reviews (Medical research) --- Reviews, Systematic (Medical research) --- Medicine --- Evidence-based medicine --- Research --- Ressenyes sistemàtiques (Investigació mèdica) --- Metaanàlisi --- Psicometria --- Revisions sistemàtiques (Investigació mèdica) --- Investigació mèdica --- Medicina basada en l'evidència

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Medical informatics --- Medicine --- Research --- Methodology. --- Data processing --- Evaluation. --- Informàtica mèdica --- Processament de dades --- Investigació mèdica

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Biology --- Biomedical engineering. --- Research. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biological research --- Biomedical research --- Enginyeria biomèdica --- Investigació mèdica

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Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal aims to publish high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modeling. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.

Systematic reviews (Medical research) --- Review Literature as Topic. --- Meta-Analysis as Topic. --- Research Design. --- Systematic reviews (Medical research) --- Investigació mèdica. --- Metaanàlisi. --- Medical Research --- Medical Research

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Medicine --- Medical writing. --- Research. --- Hygiene --- Medical sciences --- Public health --- Technical writing --- Health Workforce --- Authorship --- Investigació mèdica --- Literatura científica --- Documentació científica --- Escrits científics --- Publicacions científiques --- Informes tècnics --- Investigació --- Investigació biomèdica --- Investigació farmacèutica --- Experimentació humana en medicina --- Ressenyes sistemàtiques (Investigació mèdica) --- Animals de laboratori