Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.

Monoclonal antibodies. --- Biochemistry. --- Toxicology. --- Antibodies. --- Protein Science. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Toxicology --- Composition --- Anticossos monoclonals --- Toxicologia --- Manuals de laboratori --- Tècniques de laboratori --- Farmacologia --- Dermatotoxicologia --- Immunotoxicologia --- Neurotoxicologia --- Toxicologia ambiental --- Toxicologia experimental --- Toxicologia industrial --- Toxicologia genètica --- Toxicologia pediàtrica --- Emmetzinament --- Intoxicació --- Verins --- Immunoglobulines monoclonals --- Clonatge molecular --- Immunoglobulines --- Rituximab