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Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

Medicine --- kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability --- kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability

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• Reference Manager
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Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability

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The accurate identification of pathology in the skeleton is an extremely important goal, and the great strength of the radionuclide bone scan is its ability to identify functional change before structural change occurs. Over the years, the indications for bone scan have evolved to include benign disorders as well as malignancies. Further striking developments include the emergence of PET and of new tracers that offer enhanced capabilities, such as 18F-fluoride. The most dramatic advance, however, has been the development of hybrid imaging systems that combine the strengths of different modalities. This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.

Bones -- Radiography. --- Diagnostic imaging. --- Human skeleton -- Radiography. --- Joints -- Radiography. --- Radiology, Medical. --- Bones --- Tomography, Emission-Computed --- Musculoskeletal Diseases --- Diagnostic Imaging --- Image Interpretation, Computer-Assisted --- Radiographic Image Enhancement --- Tomography, X-Ray --- Skeleton --- Connective Tissue --- Radiography --- Musculoskeletal System --- Diseases --- Diagnostic Techniques and Procedures --- Image Enhancement --- Tomography --- Tissues --- Anatomy --- Photography --- Diagnostic Techniques, Radioisotope --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Bone and Bones --- Positron-Emission Tomography --- Tomography, X-Ray Computed --- Radionuclide Imaging --- Bone Diseases --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Musculoskeletal System Diseases --- Radionuclide imaging --- Radioisotope scanning. --- Diagnosis. --- Radioisotope scintigraphy --- Scintigraphy, Radioisotope --- Medicine. --- Nuclear medicine. --- Oncology. --- Orthopedics. --- Medicine & Public Health. --- Nuclear Medicine. --- Diagnostic imaging --- Radioactive tracers --- Radioactivity --- Radioisotopes in medical diagnosis --- Scanning systems --- Measurement --- Oncology  . --- Orthopaedics --- Orthopedia --- Surgery --- Tumors --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Physiological effect --- Radionuclide Imaging. --- Positron-Emission Tomography. --- Tomography, X-Ray Computed. --- diagnostic imaging. --- CAT Scan, X Ray --- CT X Ray --- Computed Tomography, X-Ray --- Computed X Ray Tomography --- Computerized Tomography, X Ray --- Electron Beam Tomography --- Tomography, X Ray Computed --- Tomography, X-Ray Computer Assisted --- Tomography, X-Ray Computerized --- Tomography, X-Ray Computerized Axial --- Tomography, Xray Computed --- X Ray Computerized Tomography --- X Ray Tomography, Computed --- X-Ray Computer Assisted Tomography --- X-Ray Computerized Axial Tomography --- CAT Scan, X-Ray --- CT Scan, X-Ray --- Cine-CT --- Computerized Tomography, X-Ray --- Electron Beam Computed Tomography --- Tomodensitometry --- Tomography, Transmission Computed --- X-Ray Tomography, Computed --- Beam Tomography, Electron --- CAT Scans, X-Ray --- CT Scan, X Ray --- CT Scans, X-Ray --- CT X Rays --- Cine CT --- Computed Tomography, Transmission --- Computed Tomography, X Ray --- Computed Tomography, Xray --- Computed X-Ray Tomography --- Scan, X-Ray CAT --- Scan, X-Ray CT --- Scans, X-Ray CAT --- Scans, X-Ray CT --- Tomographies, Computed X-Ray --- Tomography, Computed X-Ray --- Tomography, Electron Beam --- Tomography, X Ray Computer Assisted --- Tomography, X Ray Computerized --- Tomography, X Ray Computerized Axial --- Transmission Computed Tomography --- X Ray Computer Assisted Tomography --- X Ray Computerized Axial Tomography --- X Ray, CT --- X Rays, CT --- X-Ray CAT Scan --- X-Ray CAT Scans --- X-Ray CT Scan --- X-Ray CT Scans --- X-Ray Computed Tomography --- X-Ray Computerized Tomography --- Xray Computed Tomography --- Colonography, Computed Tomographic --- PET Scan --- Tomography, Positron-Emission --- PET Scans --- Positron Emission Tomography --- Scan, PET --- Scans, PET --- Tomography, Positron Emission --- Gamma Camera Imaging --- Radioisotope Scanning --- Scanning, Radioisotope --- Scintigraphy --- Scintiphotography --- Imaging, Gamma Camera --- Imaging, Radionuclide --- PET Imaging --- Positron-Emission Tomography Imaging --- Imaging, PET --- Imaging, Positron-Emission Tomography --- PET Imagings --- Positron Emission Tomography Imaging --- Positron-Emission Tomography Imagings --- Tomography Imaging, Positron-Emission