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This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Medicine. --- Molecular Medicine. --- Health Workforce --- Hormones tiroides --- Receptors nuclears (Bioquímica) --- Receptors cel·lulars --- Factors de transcripció --- Hormones --- Tiroide
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This surgical manual provides a step-by-step guide to various surgical procedures for patients with thyroid eye disease (TED). The key surgical steps are covered in detail, with intra-operative photographs. The manual addresses all aspects of TED, including the basic anatomy, surgical preparation, evaluation of imaging, and surgical procedures. TED is commonly encountered by oculoplastic surgeons and general ophthalmologists in their daily practice, and restoration of the normal appearance is vital to patients and their families. Surgical treatments for TED include basic oculoplastic surgery, complex eyelid surgery, strabismus surgery, orbital surgery, and aesthetic procedures. All of the contributing authors are eminent experts with vast experience in treating TED. High-resolution images will help readers understand the key surgical steps, and are combined with a minimal amount of text, reflecting the book’s focus on surgical technique. Offering a complete guide that contains all relevant surgical knowledge on TED, presented in a highly practice-oriented format, the book is a must-read for every surgeon whose work involves managing TED.
Ophthalmology. --- Medicine --- Eye --- Diseases --- Tiroide --- Oftalmopaties --- Cirurgia ocular --- Cirurgia oftalmològica --- Cirurgia --- Cirurgia de cataractes --- Queratoplàstia --- Vitrectomia --- Oftalmologia --- Malalties de l'ull --- Malalties dels ulls --- Malalties oculars --- Malalties --- Cataractes --- Conjuntivitis --- Infeccions oculars --- Manifestacions oculars de les malalties --- Oftàlmia --- Síndrome de Sjögren --- Trastorns de la visió --- Ull --- Glàndula tiroide --- Glàndules endocrines --- Hormones tiroides
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Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .
Cancer research. --- Endocrinology . --- Pathology. --- Cancer Research. --- Endocrinology. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Internal medicine --- Hormones --- Cancer research --- Uterus --- Diseases. --- Uterine diseases --- Endometri --- Càncer d'úter --- Càncer de matriu --- Càncer uterí --- Malalties uterines --- Càncer d'endometri --- Càncer de coll uterí --- Endometrium --- Mucosa uterina --- Membrana mucosa --- Úter --- Endometriosi --- Secreció --- Histamina --- Hormones esteroides --- Hormones gastrointestinals --- Hormones juvenils --- Hormones peptídiques --- Hormones pituïtàries --- Hormones tiroides --- Melatonina --- Catecolamines --- Endocrinologia --- Glàndules endocrines --- Cancer. --- Cancer Biology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors
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Thyroid gland --- Diseases. --- Tiroide --- Obesitat --- Trastorns del metabolisme --- Alteracions del metabolisme --- Desordres del metabolisme --- Malalties del metabolisme --- Malalties --- Amiloïdosi --- Calcificació --- Desequilibri àcid-base --- Errors congènits del metabolisme --- Síndrome metabòlica --- Trastorns de la pigmentació --- Trastorns del creixement --- Trastorns del metabolisme del ferro --- Trastorns del metabolisme dels lípids --- Trastorns dels humors corporals --- Adipositat --- Corpulència --- Grassor --- Sobrepès --- Pes corporal --- Trastorns de la nutrició --- Obesitat en els adolescents --- Obesitat en els infants --- Obesitat mòrbida --- Cirurgia de l'obesitat --- Persones obeses --- Glàndula tiroide --- Glàndules endocrines --- Hormones tiroides
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How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
Neurosciences. --- Human anatomy. --- Internal medicine. --- Cell biology. --- Biochemistry. --- Anatomy. --- Internal Medicine. --- Cell Biology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Medicine, Internal --- Medicine --- Anatomy, Human --- Anatomy --- Human biology --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Composition --- Neurociències --- Hormones --- Secreció --- Histamina --- Hormones esteroides --- Hormones gastrointestinals --- Hormones juvenils --- Hormones peptídiques --- Hormones pituïtàries --- Hormones tiroides --- Melatonina --- Catecolamines --- Endocrinologia --- Glàndules endocrines --- Neurociència --- Ciències neurològiques --- Ciències de la salut --- Neuroanatomia --- Neurobiologia --- Neurociència computacional --- Neuroendocrinologia --- Neurofarmacologia --- Neurogenètica --- Neuroquímica --- Sistema nerviós --- Cytology.
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This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.
Endocrinology . --- Pharmacology. --- Endocrinology. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Internal medicine --- Hormones --- Physiological effect --- Hormones tiroides --- Medicaments --- Farmacologia --- Malalties de les glàndules endocrines --- Tiroide --- Endocrinologia clínica --- Endocrinopaties --- Malalties endocrines --- Trastorns hormonals --- Diabetis --- Endocrinologia pediàtrica --- Ginecologia endocrina --- Hiperparatiroïdisme --- Hipoglucèmia --- Malalties de l'ovari --- Malalties de les glàndules suprarenals --- Malalties del testicle --- Pubertat precoç --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Quimioteràpia --- Fàrmacs --- Medicines --- Farmacopees --- Compostos bioactius --- Accés als medicaments --- Afrodisíacs --- Agents antilipèmics --- Antidiabètics --- Botànica mèdica --- Conservació de medicaments --- Contraceptius --- Diürètics --- Envasament de medicaments --- Excipients --- Farmacognòsia --- Interaccions dels medicaments --- Medicaments antineoplàstics --- Medicaments cardiovasculars --- Medicaments congelats --- Medicaments liofilitzats --- Medicaments orfes --- Medicaments peptídics --- Medicaments respiratoris --- Microbiologia farmacèutica --- Psicofàrmacs --- Prescripció de medicaments --- Preu dels medicaments --- Relaxants musculars --- Administració de medicaments --- Farmàcia --- Matèria mèdica --- Validació (Medicaments) --- Fotofarmacologia --- Endocrinology --- Pharmacology/Toxicology --- Pharmacology --- Thyroid gland --- Hypothyroidism --- TSH --- Thyroid disorders --- Metabolism --- Open Access
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