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Heterocyclic compounds. --- Tautomerism. --- Heterocyclic Compounds. --- 547.7 --- Heterocyclic compounds --- Tautomerism --- Isomerism --- Mesomerism --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds --- Compounds, Heterocyclic --- Heterocyclic compounds in general. Dioxins --- Polycyclic Compounds --- 547.7 Heterocyclic compounds in general. Dioxins --- Heterocyclic Compounds --- Heterocyclic Compound --- Compound, Heterocyclic

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Persian Gulf Syndrome --- Pyridostigmine Bromide --- Occupational Diseases --- Pyridinium Compounds --- Pyridines --- Diseases --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Chemicals and Drugs --- Pathology --- Medicine --- Health & Biological Sciences --- Diseases, Occupational --- Occupational Illnesses --- Disease, Occupational --- Illnesse, Occupational --- Illnesses, Occupational --- Occupational Disease --- Occupational Illnesse --- Accidents, Occupational --- Industry --- Occupational Medicine --- Karoshi Death --- Mestinon --- Pyridostigmine --- Bromide, Pyridostigmine --- Heterocyclic Compound --- Compound, Heterocyclic --- Compounds, Heterocyclic --- Polycyclic Compounds --- Heterocyclic Cpds, 1-Ring --- 1-Ring Heterocyclic Compounds --- 1-Ring Heterocyclic Cpds --- Heterocyclic Compounds, 1 Ring --- Heterocyclic Cpds, 1 Ring --- Gulf War Syndrome --- Syndrome, Gulf War --- Syndrome, Persian Gulf --- Environmental Exposure --- Multiple Chemical Sensitivity --- Piperidines --- Compounds, Pyridinium --- Quaternary Ammonium Compounds --- Persian Gulf Syndrome. --- Pyridostigmine Bromide. --- Occupational Diseases. --- Pyridinium Compounds. --- Pyridines. --- Disease. --- Heterocyclic Compounds, 1-Ring. --- Heterocyclic Compounds.

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The Special Issue "Anticancer Drugs 2021" of Pharmaceuticals is focused on recent significant advances in the design, synthesis, molecular mechanism of action and therapeutic applications of anticancer drugs. This collection of preclinical research papers and reviews includes designed chemotherapeutic agents, targeted therapies and biological agents. The rationalization for the biological activity of these drugs is presented, which helps to guide the design of more effective agents. Structure–activity relationships, together with the biological context in which targets are selected for oncology drug development, are also considered.

Research & information: general --- Chemistry --- thymidylate synthase --- cytotoxicity --- 1,2,3-triazole --- 1,3,4-oxadiazole --- 5-fluoruracil --- pemetrexed --- docking --- 3,4′-bis-guanidino --- 3-amino-4′-guanidino --- diphenyl ether --- phenyl pyridyl ether --- intramolecular hydrogen bond --- cancer cell viability --- HL-60 --- BRAF --- apoptosis --- thieno[2,3-d][1,2,3]triazine --- acetamide --- H1299 --- HER2 --- EGFR --- Bcl-2 inhibitors --- Indole-based analogues --- benzimidazole --- MTT cytotoxic assay --- cell cycle analysis --- DNA fragmentation --- ELISA --- solid/lipid nanoparticles --- phenstatin --- letrozole --- tubulin polymerisation inhibitor --- aromatase inhibitor --- breast cancer --- hybrid molecule --- dual-targeting molecule --- designed multiple ligand --- NaMSA --- cyclophosphamide --- histopathology --- testis --- urinary bladder --- anticancer agents --- enantioselective synthesis --- gastric adenocarcinoma --- tryptophanol --- concentration-guided dosing --- model informed dosing --- physiologically based pharmacokinetics --- sorafenib --- tyrosil-DNA-phosphodiesterase 1 --- adamantane --- resin acid --- TDP1 --- cytotoxic agents --- apoptosis induction --- HT-29 cells --- MDA-MB-231 cells --- mechanism prediction --- STAT inhibitors --- miR-21 --- hydrazide derivatives --- nitrogen scaffolds --- mitoxantrone --- cardiotoxicity --- inflammation --- oxidative stress --- age --- cumulative dose --- Trk --- NTRK --- tissue-agnostic --- larotrectinib --- entrectinib --- Trk fusion --- protein kinase inhibitors --- USFDA --- cancer --- patent review --- generic product --- doxazosin --- MD simulations --- combretastatin A-4 --- cytotoxic activity --- hybrid compounds --- indazole --- mucin --- MUC1 --- MUC16 --- immunotherapy --- cancer vaccine --- CAR (chimeric antigen receptor) --- ADC (antibody-drug conjugate) --- thiourea --- interleukin-6 --- trypan blue assay --- chalcones --- exportin-1 --- covalent binding --- CovDock --- anticancer activity --- xanthone --- in vitro --- in vivo --- isolation --- synthesis --- heterocyclic compound --- benzenesulfonamides --- imidazoles --- alkylated --- colony formation --- tumor spheroids --- HDAC inhibitors --- chalcone --- dual inhibitors --- carvedilol --- kidney --- toxicity --- 7-deaza-4′-thioadenosine derivatives --- multi-kinase inhibitor --- anticancer --- nucleoside --- Imiquimod --- drug efflux --- multidrug resistance --- Toll-Like Receptor --- n/a --- 3,4'-bis-guanidino --- 3-amino-4'-guanidino --- 7-deaza-4'-thioadenosine derivatives

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Around-the-clock tobacco talks, multibillion-dollar lawsuits against the major cigarette companies, and legislative wrangling over how much to tax a pack of cigarettes-these are some of the most recent episodes in the war against the tobacco companies. The Cigarette Papers shows what started it all: revelations that tobacco companies had long known the grave dangers of smoking, and did nothing about it.In May 1994 a box containing 4,000 pages of internal tobacco industry documents arrived at the office of Professor Stanton Glantz at the University of California, San Francisco. The anonymous source of these "cigarette papers" was identified only as "Mr. Butts." These documents provide a shocking inside account of the activities of one tobacco company, Brown & Williamson, over more than thirty years. Quoting extensively from the documents themselves and analyzing what they reveal, The Cigarette Papers shows what the tobacco companies have known and galvanizes us to take action.

Tobacco industry --- Tobacco use --- Nicotine --- Smoking. --- Tobacco. --- Cigarettes --- Habits --- Pyridines --- Solanaceae --- Solanaceous Alkaloids --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Embryophyta --- Streptophyta --- Viridiplantae --- Additives --- Cigar Smoking --- Cigarette Smoking --- Hookah Smoking --- Smoking, Tobacco --- Waterpipe Smoking --- Pipe Smoking --- Tobacco Smoking --- Smoking, Cigar --- Smoking, Cigarette --- Smoking, Hookah --- Smoking, Pipe --- Smoking, Waterpipe --- Nicotiana tabacums --- Nicotianas --- Tobaccos --- tabacum, Nicotiana --- Nicotine Bitartrate --- Nicotine Tartrate --- Bitartrate, Nicotine --- Tartrate, Nicotine --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Plant --- Land Plants --- Land Plant --- Plant, Land --- Plants, Land --- Compounds, Heterocyclic --- Heterocyclic Cpds, 1-Ring --- 1-Ring Heterocyclic Compounds --- 1-Ring Heterocyclic Cpds --- Heterocyclic Compounds, 1 Ring --- Heterocyclic Cpds, 1 Ring --- Angiospermae --- Liliopsida --- Magnoliopsida --- Angiosperm --- Liliopsidas --- Magnoliopsidas --- Habit Disturbances --- Habit Disturbance --- Tobacco manufacture and trade --- Tobacco products industry --- Cigarets --- Cigarette habit --- Cigarette smoking --- Tobacco smoking --- Green Plants --- Green Plant --- Plant, Green --- Plants, Green --- Solanum Alkaloids --- Alkaloids, Solanaceous --- Alkaloids, Solanum --- Acnistus --- Brugmansia --- Dunalia --- Brugmansias --- Dunalias --- -Tobacco --- -Tobacco industry --- -Cigarettes --- Tobacco products --- Plant products industry --- Smoking --- Industry --- Technology, Industry, and Agriculture --- Technology, Industry, Agriculture --- Angiosperms --- Behavior --- Alkaloids --- Behavior and Behavior Mechanisms --- Chemicals and Drugs --- Psychiatry and Psychology --- Plants --- Eukaryota --- Organisms --- Tobacco --- Business & Economics --- Industries --- Smoking Behaviors --- Smoking Habit --- Behavior, Smoking --- Behaviors, Smoking --- Habit, Smoking --- Habits, Smoking --- Smoking Behavior --- Smoking Habits --- Tertiary Sector --- Sector, Tertiary --- Sectors, Tertiary --- Tertiary Sectors --- Commerce --- Ethics, Business --- Nicotiana tabacum --- Nicotiana --- Acceptance Process --- Acceptance Processes --- Behaviors --- Process, Acceptance --- Processes, Acceptance --- Botany --- Plant Proteins --- Ethnopharmacology --- Polycyclic Compounds --- Plant Alkaloids --- Alkaloids, Plant --- Angiosperma --- Arecidae --- Asteridae --- Caryophyllidae --- Commelinidae --- Dicotyledoneae --- Dilleniidae --- Flowering Plants --- Hamamelidae --- Hamamelididae --- Icacinales --- Liliatae --- Liliidae --- Magnoliatae --- Metteniusales --- Oncothecales --- Rosidae --- Vahliales --- Zingiberidae --- Flowering Plant --- Icacinale --- Metteniusale --- Oncothecale --- Plant, Flowering --- Plants, Flowering --- Vahliale --- Piperidines --- Habit --- Health aspects. --- legislation. --- adverse effects. --- Health aspects --- United States --- Additives. --- Tobacco industry - United States. --- Tobacco - Health aspects. --- #SBIB:002.IO --- #SBIB:316.334.3M20 --- #SBIB:35H411 --- #SBIB:35H436 --- Sociale epidemiologie en etiologie: sociale aspecten van ziekte en gezondheid --- Beleidscyclus: voorbereiding (inclusief planning) --- Beleidssectoren: welzijn, volksgezondheid en cultuur --- Behavior And Behavior Mechanism --- Heterocyclic Compound --- Compound, Heterocyclic --- Alkaloid --- Plant Alkaloid --- Alkaloid, Plant --- Technology --- Psychology --- Factors, Psychological --- Psychological Factors --- Psychological Side Effects --- Psychologists --- Psychosocial Factors --- Side Effects, Psychological --- Factor, Psychological --- Factor, Psychosocial --- Factors, Psychosocial --- Psychological Factor --- Psychological Side Effect --- Psychologist --- Psychosocial Factor --- Side Effect, Psychological --- Arts, Industrial --- Industrial Arts --- Cloud Computing --- Industry. --- Cigarettes. --- Habits. --- Technology, Industry, and Agriculture. --- Pyridines. --- Solanaceae. --- Solanaceous Alkaloids. --- Technology. --- Magnoliopsida. --- Behavior. --- Alkaloids. --- Heterocyclic Compounds, 1-Ring. --- Heterocyclic Compounds. --- Embryophyta. --- Behavior and Behavior Mechanisms. --- Psychology. --- Streptophyta. --- Viridiplantae. --- Plants. --- Eukaryota. --- Nicotine. --- United States.

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The goal of clinical laboratories is to produce accurate information for clinical decision making in medicine. More than half of the medical decisions made depend on clinical laboratory tests. Patient safety represents an important and critical problem for laboratories. They need to assure that the information they deliver to physicians is accurate, and therefore safe for clinicians to use. Endogenous compounds can interfere with laboratory tests, decreasing accuracy and threatening patient safety. Elevated bilirubin (bilirubinemia) and elevated lipids (lipemia) are common conditions that cause significant interferences with laboratory results. Clinicians depend on laboratories to detect these endogenous interferences. Laboratories must have a means to detect these endogenous interferences, make decisions about reporting results, and evaluate their impact. Most clinical pathology books provide only an abbreviated introduction to the subject, or provide a long list of references, without the necessary foundation for evaluating their significance. Package inserts typically provide scant information. This book provides the empirical and theoretical foundation for these interferences, describes the clinical settings where they occur, and explains their evaluation and detection, allowing the laboratory to interpret the available data on interferences and make the appropriate decision to effectively report test results while protecting patient safety.

Bilirubin -- Isolation and purification. --- Clinical chemistry tests -- Methods. --- Lipids -- Isolation and purification. --- Patient safety. --- Laboratory Techniques and Procedures --- Epidemiologic Research Design --- Bile Pigments --- Investigative Techniques --- Chemicals and Drugs --- Diagnosis --- Pigments, Biological --- Tetrapyrroles --- Epidemiologic Methods --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Heterocyclic Compounds with 4 or More Rings --- Macrocyclic Compounds --- Biological Factors --- Pyrroles --- Heterocyclic Compounds --- Azoles --- Polycyclic Compounds --- Heterocyclic Compounds, 1-Ring --- Bilirubin --- Methods --- Lipids --- Specimen Handling --- Clinical Chemistry Tests --- Reproducibility of Results --- Medicine --- Health & Biological Sciences --- Pathology --- Face Validity --- Reliability (Epidemiology) --- Reliability of Results --- Reproducibility of Findings --- Test-Retest Reliability --- Validity (Epidemiology) --- Reliability and Validity --- Reliability of Result --- Reproducibility Of Result --- Reproducibility of Finding --- Validity of Result --- Validity of Results --- Finding Reproducibilities --- Finding Reproducibility --- Of Result, Reproducibility --- Of Results, Reproducibility --- Reliabilities, Test-Retest --- Reliability, Test-Retest --- Result Reliabilities --- Result Reliability --- Result Validities --- Result Validity --- Result, Reproducibility Of --- Results, Reproducibility Of --- Test Retest Reliability --- Validity and Reliability --- Validity, Face --- Chemistry Test, Clinical --- Clinical Chemistry Test --- Test, Clinical Chemistry --- Tests, Clinical Chemistry --- Chemistry Tests, Clinical --- Chemistry, Clinical --- Specimen Collection --- Collection, Specimen --- Collections, Specimen --- Handling, Specimen --- Handlings, Specimen --- Specimen Collections --- Specimen Handlings --- Lipid --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Bilirubin IX alpha --- Bilirubin, (15E)-Isomer --- Bilirubin, (4E)-Isomer --- Bilirubin, (4E,15E)-Isomer --- Bilirubin, Calcium Salt --- Bilirubin, Disodium Salt --- Bilirubin, Monosodium Salt --- Calcium Bilirubinate --- Hematoidin --- delta-Bilirubin --- Bilirubinate, Calcium --- Calcium Salt Bilirubin --- Disodium Salt Bilirubin --- Monosodium Salt Bilirubin --- Salt Bilirubin, Calcium --- delta Bilirubin --- Heterocyclic Cpds, 1-Ring --- 1-Ring Heterocyclic Compounds --- 1-Ring Heterocyclic Cpds --- Heterocyclic Compounds, 1 Ring --- Heterocyclic Cpds, 1 Ring --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Azole --- Heterocyclic Compound --- Compound, Heterocyclic --- Compounds, Heterocyclic --- Pyrrole --- Biologic Agents --- Biologic Factors --- Biological Factor --- Factor, Biologic --- Factor, Biological --- Factors, Biological --- Biologic Agent --- Biological Agent --- Biological Agents --- Agent, Biologic --- Agent, Biological --- Agents, Biologic --- Agents, Biological --- Biologic Factor --- Factors, Biologic --- Biological Products --- Macrocycle Compounds --- Spherands --- Torands --- Compounds, Macrocycle --- Compounds, Macrocyclic --- Bridged-Ring Compounds --- Five Ring Heterocyclic Compounds --- Four Ring Heterocyclic Compounds --- Fused Heterocyclic Compounds, Five-Ring --- Fused Heterocyclic Compounds, Four-Ring --- Heterocyclic Compounds with Four or More Rings --- Heterocyclic Compounds, 4-Ring --- Heterocyclic Compounds, 5-Ring --- Heterocyclic Cpds, 4 Ring --- Heterocyclic Cpds, 4 or More Rings --- Heterocyclic Cpds, 5 Ring --- 4-Ring Heterocyclic Compounds --- 5-Ring Heterocyclic Compounds --- Fused Heterocyclic Compounds, Five Ring --- Fused Heterocyclic Compounds, Four Ring --- Heterocyclic Compounds, 4 Ring --- Heterocyclic Compounds, 5 Ring --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Diagnose --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Disease --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- Tetrapyrrole --- Biological Pigments --- Coloring Agents --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Bile Pigment --- Bilin --- Pigment, Bile --- Pigments, Bile --- Design, Epidemiologic Research --- Designs, Epidemiologic Research --- Epidemiologic Research Designs --- Epidemiological Research Design --- Research Design, Epidemiologic --- Research Designs, Epidemiologic --- Design, Epidemiological Research --- Designs, Epidemiological Research --- Epidemiological Research Designs --- Research Design, Epidemiological --- Research Designs, Epidemiological --- diagnosis --- methods --- Specimen Handling. --- Reproducibility of Results. --- Patient Safety. --- methods. --- isolation & purification. --- isolation & pruification. --- Patient Safeties --- Safeties, Patient --- Safety, Patient --- Risk Management --- Bilirubinemia. --- Clinical Pathology. --- Interference. --- Lipemia.