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Heparin

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Heparin. --- Heparin --- Héparine

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The aim of this thesis is to provide a summary that runs the essence of the pathology: “thrombopenia induced by heparin”. Heparin is an anticoagulant commonly used in the context of the prevention or cure of thromboembolic events. The thrombopenia induced by heparin has a low prevalence but clinical complications can be severe. These should not be ignored by the medical team. Prevention or treatment of thromboembolic events at the patients under heparin will require diagnostics to highlight them as early as possible the pathology. The pathogenesis, the effects of the thrombocytopenia induced by heparin, existing diagnoses and treatment options are discussed throughout this work. Le but de ce mémoire est de fournir un résumé qui parcourt les grandes lignes de la pathologie : « Thrombopénie induite par l'héparine ». L'héparine est un anticoagulant couramment utilisé dans le cadre de la prévention ou de la guérison d'évènements thromboemboliques. La thrombopénie induite par l'héparine possède une faible incidence mais les complications cliniques peuvent être graves. Ces dernières ne doivent pas être ignorées par les corps médicaux. Lors de la prévention ou la prise en charge d'évènements thromboemboliques chez les patients sous héparine, il sera donc nécessaire d'avoir recours à des diagnostics afin de mettre en évidence une TIH ou non le plus précocement possible la pathologie. La pathogenèse, les conséquences de la thrombopénie induite par l'héparine, les diagnostics existants et les traitements possibles sont discutés tout au long de ce travail.

Thrombocytopenia --- Heparin

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This dissertation by Mattias Törnudd investigates the effects of protamine on platelet function and coagulation in cardiac surgery, specifically focusing on the use of cardiopulmonary bypass (CPB). The research examines how protamine, used to reverse heparin's anticoagulant effects post-surgery, impacts platelet activity and coagulation. It explores dosing strategies to minimize the negative effects of protamine and reduce the risk of residual heparin. The study also evaluates differences in platelet function between venous and arterial blood. Aimed at medical professionals and researchers, the work contributes to the understanding of hemostatic challenges in cardiac surgery and offers insights into managing coagulation effectively.

Coagulation. --- Heparin.

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Heparin --- Thrombocytopenia --- Thrombocytopenia --- Anticoagulants --- Heparin