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The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and cellular mechanisms in hematological neoplasia. Physiopathogenesis of Hematological Cancer presents a concise overview of the cellular and molecular biology of myelo- and Lymphoproliferative disorders. The expert reviews presented within this e-book are also accompanied by bibliographic references for relevant scientific literature. This book should prove to be a valuable reference tool for both med
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La collection "Cas cliniques pour l'ECN" a pour objectif de délivrer des conseils pratiques aux candidats sur le fond et la forme.Elle est constituée de 50 dossiers cliniques par ouvrage qui permettent à l'étudiant préparant l'Examen Classant National de s'entraîner à l'épreuve rédactionnelle clinique. Ces dossiers sont rédigés par un professeur et un interne. Ils comportent : - le détail de la notation- des commentaires aux réponses, explications complémentaires - des références actualisées et des pistes bibliographiques - le niveau de difficulté. A l'occasion de cette seconde édition, les auteurs des ouvrages ont actualisé tant les références bibliographiques que les questions elles-mêmes, et des cas cliniques nouveaux ont été ajoutés quand cela nous semblait nécessaire. Implication de Professeurs des Universités de toutes les spécialités concernées. Conseils pratiques par des Internes bien classés. Grille de points. Explications complémentaires. Références actualisées. Cotation des cas cliniques par difficulté.
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Hematology --- Hematological oncology --- Oncology --- Blood --- Hematologic Diseases --- Neoplasms --- Hematology. --- Medical Oncology. --- Hematological oncology. --- Oncology. --- Diseases --- therapy. --- Diseases.
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Hematology --- Hematological oncology --- Oncology --- Blood --- Hematologic Diseases --- Neoplasms --- Hematology. --- Medical Oncology. --- Blood --- Hematological oncology. --- Hematology. --- Oncology. --- Diseases --- therapy. --- therapy. --- Diseases.
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Oncology. Neoplasms --- Hematological oncology --- Hématocancérologie --- Periodicals --- Périodiques --- Hematology. --- Medical Oncology. --- Hématologie --- Hematological oncology. --- Périodiques. --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Health Sciences --- Clinical Medicine --- Hematology --- Oncology --- Medical Oncology
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Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of blood diseases. This has in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options in hematology requires a frequent update of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research in hematological diseases with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients, as well as on some molecular and pathogenetic mechanisms and the respective translation into novel therapies.
Hematology. --- Haematology --- Internal medicine --- Blood --- Diseases --- Medicine --- Hematological Oncology --- Hematology --- Health Sciences
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This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
Myelodysplastic syndromes. --- Bone marrow --- Dysmyelopoietic syndromes --- Dysplasia --- Syndromes --- Preleukemia --- Diseases --- Medicine --- Hematological Oncology --- Hematology --- Health Sciences
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Hematology --- Hematological oncology --- Oncology --- Blood --- Hematologic Diseases --- Neoplasms --- Hematology. --- Medical Oncology. --- Diseases --- therapy.
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Blood --- Hematological oncology --- Hematologic Neoplasms --- Leukemia --- Multiple Myeloma --- Multiple Myeloma --- Diseases
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This book presents a general introduction to and review of HIV-associated hematological malignancies, with a special focus on practical management issues. Each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. In addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. Separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. Many of the chapters are written by experts who have been instrumental in shifting the balance for people living with HIV and blood cancers. While two decades ago this diagnosis represented a death sentence, advances in treatment have transformed these cancers into often curable conditions. Nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression. This book will be an invaluable source of information for all practitioners in the fields of clinical hematology and medical oncology and HIV medicine.
Pathology --- Medicine --- Health & Biological Sciences --- Hematological oncology. --- Hematology --- Oncology --- Hematology. --- Oncology . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Diseases
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