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Biotechnologie --- Biotechnology --- Communicable diseases--Vaccination --- Inoculation --- Preventive inoculation --- Vaccinatie --- Vaccinatie van dieren --- Vaccination --- Vaccination des animaux --- Vaccination of animals --- Vaccines --- Vaccins --- Biotechnology. --- Vaccines. --- 573.6 --- Biotechnologies --- isolation & purification. --- Applied biology in general --- 573.6 Applied biology in general --- Respiratoire (Appareil). --- Ademhalingsstelsel. --- Technology --- Biological Products --- Biological Science Disciplines --- Technology, Industry, and Agriculture --- Complex Mixtures --- Natural Science Disciplines --- Disciplines and Occupations --- Technology, Industry, Agriculture --- Chemicals and Drugs --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologics --- Natural Products --- Drugs, Biologic --- Drugs, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Biological Factors --- Arts, Industrial --- Industrial Arts --- Cloud Computing --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Mixtures, Complex --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biopharmaceutical --- Natural Product --- Drug, Biologic --- Drug, Biological --- Medicine, Biological --- Product, Biologic --- Product, Biological --- Product, Natural --- Vaccine --- Complex Extract --- Complex Mixture --- Crude Extract --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- isolation & purification

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Anne Kantardjieff and Weichang Zhou Mammalian Cell Cultures for Biologics Manufacturing Scott Estes and Mark Melville Mammalian Cell Line Developments in Speed and Efficiency Susan Abu-Absi, Sen Xu, Hugh Graham, Nimish Dalal, Marcus Boyer and Kedar Dave Cell Culture Process Operations for Recombinant Protein Production Sadettin S. Ozturk Equipment for Large-Scale Mammalian Cell Culture Daniel M. Marasco, Jinxin Gao, Kristi Griffiths, Christopher Froggatt, Tongtong Wang and Gan Wei Development and Characterization of a Cell Culture Manufacturing Process Using Quality by Design (QbD) Principles Michael J. Gramer Product Quality Considerations for Mammalian Cell Culture Process Development and Manufacturing Dayue Chen Safety Assurance for Biologics Manufactured in Mammalian Cell Cultures: A Multitiered Strategy Dawn M. Ecker and Thomas C. Ransohoff Mammalian Cell Culture Capacity for Biopharmaceutical Manufacturing Karthik P. Jayapal and Chetan T. Goudar Transcriptomics as a Tool for Assessing the Scalability of Mammalian Cell Perfusion Systems Enda Moran and Patrick Gammell Lifecycle Management for Recombinant Protein Production Using Mammalian Cell Culture Technology.

Chemistry. --- Pharmaceutical technology. --- Biotechnology. --- Cell culture. --- Cell Culture. --- Pharmaceutical Sciences/Technology. --- Biologicals --- Cell culture --- Vertebrates --- Proteins --- Complex Mixtures --- Culture Techniques --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Chordata --- Clinical Laboratory Techniques --- Investigative Techniques --- Animals --- Eukaryota --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Organisms --- Cell Culture Techniques --- Biological Products --- Mammals --- Recombinant Proteins --- Mechanical Engineering --- Engineering & Applied Sciences --- Bioengineering --- Proteins, Biosynthetic --- Proteins, Recombinant DNA --- Biosynthetic Proteins --- DNA Recombinant Proteins --- DNA Proteins, Recombinant --- Proteins, DNA Recombinant --- Proteins, Recombinant --- Recombinant DNA Proteins --- Recombinant Proteins, DNA --- Mammalia --- Mammal --- Biologic Products --- Products, Biological --- Biologics --- Natural Products --- Products, Biologic --- Products, Natural --- Cell Culture --- Cell Culture Technique --- Cell Cultures --- Culture Technique, Cell --- Culture Techniques, Cell --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Animalia --- Animal --- Metazoa --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Diagnoses, Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Technique, Clinical Laboratory --- Techniques, Clinical Laboratory --- Chordates --- Chordate --- Culture Technique --- Technique, Culture --- Techniques, Culture --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Mixtures, Complex --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Vertebrate --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Biologicals. --- Cultures (Biology) --- Cytology --- Technique --- Biological products --- Medical supplies --- Technology --- Chemical engineering --- Genetic engineering --- Chemistry --- Pharmaceutical technology --- Biotechnology

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This book provides a systematic review of the literature and a comprehensive evaluation of the health hazards of transport-related air pollution. The review addresses: factors determining emissions, the contribution of traffic to pollution levels, human exposure and the results of epidemiological and toxicological studies to identify and measure the health effects. This book is designed for two main audiences: policy-makers and experts in transport-related air pollution and public health. Accordingly, it offers both summary information for the former and full discussion, primarily for the latt

Blootstelling aan het milieu --- Environmental exposure --- Etat et médicine --- Exposition environmentale --- Exposure [Environmental ] --- Geneeskunde en staat --- Geneeskunde--Overheidsbeleid --- Geneeskunde--Regeringspolitiek --- Gezondheidsbeleid --- Gezondheidszorg--Overheidsbeleid --- Gezondheidszorg--Regeringspolitiek --- Health policy --- Medical care--Government policy --- Medical policy --- Medicine and state --- Milieu [Blootstelling aan het ] --- Médecine--Politique gouvernementale --- Médicine et état --- Policy [Medical ] --- Politique de santé --- Politique médicale --- Politique sanitaire --- Protection sanitaire --- Public health--Government policy --- Santé [Politique de ] --- Santé publique--Politique gouvernementale --- Soins médicaux--Politique gouvernementale --- Staat en geneeskunde --- State and medicine --- Air -- Pollution -- Health aspects. --- Air -- Pollution. --- Transportation -- Environmental aspects. --- Environmental Exposure --- Vehicle Emissions --- Environmental Pollution --- Complex Mixtures --- Chemicals and Drugs --- Public Health --- Environment and Public Health --- Health Care --- Environmental Health --- Health & Biological Sciences --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Mixtures, Complex --- Pollution, Environmental --- Soil Pollution --- Pollution, Soil --- Vehicular Emissions --- Automobile Exhaust --- Diesel Exhaust --- Engine Exhaust --- Emission, Vehicle --- Emission, Vehicular --- Emissions, Vehicle --- Emissions, Vehicular --- Exhaust, Automobile --- Exhaust, Diesel --- Exhaust, Engine --- Vehicle Emission --- Vehicular Emission --- Exposure, Environmental --- Environmental Exposures --- Exposures, Environmental --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Environmental Pollutants --- Sentinel Species --- Traffic-Related Pollutants --- Transportation Emissions --- Emissions, Transportation --- Pollutants, Traffic-Related --- Traffic Related Pollutants --- Traffic-Related Pollution --- Air --- Pollution --- Complex Extract --- Complex Mixture --- Crude Extract --- Extract, Complex --- Extract, Crude --- Mixture, Complex

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Tuberculosis --- BCG Vaccine --- Tuberculosis Vaccines --- Mycobacterium Infections --- Actinomycetales Infections --- Bacterial Vaccines --- Gram-Positive Bacterial Infections --- Vaccines --- Biological Products --- Bacterial Infections --- Complex Mixtures --- Bacterial Infections and Mycoses --- Diseases --- Chemicals and Drugs --- Infectious Diseases --- Medicine --- Health & Biological Sciences --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Complex Extract --- Complex Mixture --- Crude Extract --- Mixtures, Complex --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- Bacterial Infection --- Infection, Bacterial --- Infections, Bacterial --- Bacterial Disease --- Bacterial Diseases --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biologics --- Biopharmaceutical --- Natural Product --- Natural Products --- Drug, Biologic --- Drug, Biological --- Drugs, Biologic --- Drugs, Biological --- Medicine, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Product, Biologic --- Product, Biological --- Product, Natural --- Biological Factors --- Vaccine --- Infections, Gram-Positive Bacterial --- Bacterial Infections, Gram-Positive --- Bacterial Infection, Gram-Positive --- Bacterial Infections, Gram Positive --- Gram Positive Bacterial Infections --- Gram-Positive Bacterial Infection --- Infection, Gram-Positive Bacterial --- Infections, Gram Positive Bacterial --- Bacterial Vaccine --- Bacterin --- Vaccine, Bacterial --- Vaccines, Bacterial --- Infections, Actinomycetales --- Infections, Actinomycete --- Actinomycete Infections --- Actinomycetales Infection --- Actinomycete Infection --- Infection, Actinomycetales --- Infection, Actinomycete --- Infections, Mycobacterium --- Infection, Mycobacterium --- Mycobacterium Infection --- Vaccines, Tuberculosis --- Calmette's Vaccine --- Bacillus Calmette Guerin Vaccine --- Calmette Guerin Bacillus Vaccine --- Calmette Vaccine --- Calmettes Vaccine --- Vaccine, BCG --- Vaccine, Calmette's --- Koch's Disease --- Kochs Disease --- Mycobacterium tuberculosis Infection --- Infection, Mycobacterium tuberculosis --- Infections, Mycobacterium tuberculosis --- Koch Disease --- Mycobacterium tuberculosis Infections --- Tuberculoses --- Antitubercular Agents --- Tuberculin Test --- Interferon-gamma Release Tests --- history. --- prevention & control. --- North America. --- Northern America --- Drug Therapy --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Pharmacologic Actions --- drug therapy --- therapeutic use

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Networks of Innovation offers an historical perspective on the manner in which private-sector organizations have acquired, sustained, and periodically lost the ability to develop, manufacture, and market new serum antitoxins and vaccines. The primary focus is on the H. K. Mulford Company, on Sharp and Dohme, which acquired Mulford in 1929, and upon Merck & Co Inc., which merged with Sharp and Dohme in 1953. By surveying a century of innovation in biologicals, the authors are able to analyze the conditions that either promoted or prevented creative changes in this important industry. They show how the activities of these three commercial enterprises were related to a series of complex, evolving networks of scientific, governmental, and medical institutions in the United States and abroad. This is the first such history to draw exclusively on sources internal to Merck, one of the world's leading innovators in modern vaccines and pharmaceuticals.

Industry --- Biological Products --- History, Modern 1601 --- -History, 20th Century --- Vaccines --- Drug Industry --- Technology, Industry, and Agriculture --- Complex Mixtures --- History --- Technology, Industry, Agriculture --- Humanities --- Chemicals and Drugs --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Aspects, Historical --- Historical Aspects --- Aspect, Historical --- Historical Aspect --- Histories --- Complex Extracts --- Crude Extracts --- Extracts, Complex --- Extracts, Crude --- Complex Extract --- Complex Mixture --- Crude Extract --- Mixtures, Complex --- Extract, Complex --- Extract, Crude --- Mixture, Complex --- Industries, Pharmaceutic --- Industry, Drug --- Industry, Pharmaceutic --- Industry, Pharmaceutical --- Pharmaceutical Industry --- Drug Industries --- Industries, Drug --- Industries, Pharmaceutical --- Pharmaceutic Industries --- Pharmaceutic Industry --- Pharmaceutical Industries --- Vaccine --- 20th Cent. History (Medicine) --- 20th Cent. History of Medicine --- 20th Cent. Medicine --- Historical Events, 20th Century --- History of Medicine, 20th Cent. --- History, Twentieth Century --- Medical History, 20th Cent. --- Medicine, 20th Cent. --- 20th Century History --- 20th Cent. Histories (Medicine) --- 20th Century Histories --- Cent. Histories, 20th (Medicine) --- Cent. History, 20th (Medicine) --- Century Histories, 20th --- Century Histories, Twentieth --- Century History, 20th --- Century History, Twentieth --- Histories, 20th Cent. (Medicine) --- Histories, 20th Century --- Histories, Twentieth Century --- History, 20th Cent. (Medicine) --- Twentieth Century Histories --- Twentieth Century History --- History of Medicine, Modern --- Medicine, Modern --- Modern History (Medicine) --- Modern Medicine --- History, Modern --- Modern History --- 1601- History, Modern --- History, Modern (Medicine) --- Modern 1601- History --- Biologic Drugs --- Biologic Medicines --- Biologic Pharmaceuticals --- Biologic Products --- Biological Drugs --- Biological Medicines --- Biologicals --- Biopharmaceuticals --- Products, Biological --- Biologic --- Biologic Drug --- Biologic Product --- Biological --- Biological Drug --- Biological Medicine --- Biological Product --- Biologics --- Biopharmaceutical --- Natural Product --- Natural Products --- Drug, Biologic --- Drug, Biological --- Drugs, Biologic --- Drugs, Biological --- Medicine, Biological --- Medicines, Biologic --- Medicines, Biological --- Pharmaceuticals, Biologic --- Product, Biologic --- Product, Biological --- Product, Natural --- Biological Factors --- Tertiary Sector --- Industries --- Sector, Tertiary --- Sectors, Tertiary --- Tertiary Sectors --- Commerce --- Ethics, Business --- Merck, Sharp & Dohme International --- Merck & Co. --- Merck Sharp and Dohme International --- History. --- Vaccines industry --- Vaccine industry --- Pharmaceutical industry --- Arts and Humanities