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99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that was introduced into clinical routine for myocardial perfusion imaging more than two decades ago. Although today the main application of 99mTc-sestamibi SPECT remains the imaging of myocardial perfusion, it is also an accepted and well-proven imaging technique for a variety of oncologic and non-oncologic applications, including brain, breast, and thyroid cancer and thyroid and parathyroid adenoma. Its efficacy in a range of indications ensures that 99mTc-sestamibi SPECT will remain widely used despite the rapid diffusion of 18F-FDG PET.                         99mTc-Sestamibi – Clinical Applications provides a detailed and informative overview of almost all the oncologic and non-oncologic applications of 99mTc-sestamibi SPECT, including several relatively rare indications. Different disease-related protocols for 99mTc-sestamibi SPECT are presented, and for each disease a comprehensive summary of the relevant pathology and epidemiology is provided. Throughout, there is a strong emphasis on the practical aspects of use of this popular tracer, including instructions for the preparation of several commercially available tracer kits. Clinical practitioners will find this book to be an invaluable guide to the application and benefits of 99mTc-sestamibi SPECT in both the inpatient and the outpatient setting.

Cardiology. --- Magnetic resonance imaging. --- Nuclear medicine. --- Oncology. --- Radiology, Medical. --- Single-photon emission computed tomography --- Diagnostic Techniques, Radioisotope --- Organotechnetium Compounds --- Diagnostic Imaging --- Investigative Techniques --- Nitriles --- Organometallic Compounds --- Diagnostic Techniques and Procedures --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Organic Chemicals --- Diagnosis --- Inorganic Chemicals --- Chemicals and Drugs --- Technetium Tc 99m Sestamibi --- Methods --- Radionuclide Imaging --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Technetium --- Radioisotope scanning. --- Radioisotopes in medical diagnosis. --- Isotopes. --- Diagnostic radioisotopes --- Radiodiagnosis --- Radioisotopes --- Radioisotope scintigraphy --- Radionuclide imaging --- Scintigraphy, Radioisotope --- Diagnostic use --- Medicine. --- Radiology. --- Medicine & Public Health. --- Nuclear Medicine. --- Imaging / Radiology. --- Diagnostic imaging --- Radioactive tracers --- Radioactivity --- Radioisotopes in medical diagnosis --- Scanning systems --- Nuclear medicine --- Measurement --- Oncology  . --- Tumors --- Heart --- Internal medicine --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Diseases --- Physiological effect --- Radiological physics --- Physics --- Radiation

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Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Radiopharmaceuticals. --- Single-photon emission computed tomography. --- Tomography, Emission. --- Diagnostic imaging --- Molecular diagnosis --- Nuclear medicine --- Tomography, Emission --- Tomography, Emission-Computed --- Indicators and Reagents --- Radionuclide Imaging --- Tomography --- Image Enhancement --- Image Interpretation, Computer-Assisted --- Laboratory Chemicals --- Diagnostic Imaging --- Photography --- Diagnostic Techniques, Radioisotope --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Diagnostic Techniques and Procedures --- Chemicals and Drugs --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Positron-Emission Tomography --- Tomography, Emission-Computed, Single-Photon --- Radiopharmaceuticals --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Technological innovations --- Molecular diagnosis. --- Radioisotope scanning. --- Radioisotopes in medical diagnosis. --- Diagnostic radioisotopes --- Radiodiagnosis --- Radioisotopes --- Radioisotope scintigraphy --- Radionuclide imaging --- Scintigraphy, Radioisotope --- Molecular diagnostics --- Diagnostic use --- Molecular aspects --- Medicine. --- Radiology. --- Nuclear medicine. --- Cardiology. --- Oncology. --- Neurology. --- Pathology. --- Medicine & Public Health. --- Nuclear Medicine. --- Imaging / Radiology. --- Radioactive tracers --- Radioactivity --- Radioisotopes in medical diagnosis --- Scanning systems --- Molecular biology --- Measurement --- Radiology, Medical. --- Oncology  . --- Nervous system --- Neuropsychiatry --- Heart --- Internal medicine --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Physiological effect --- Neurology . --- Radiological physics --- Physics --- Radiation