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Over 25 million people in the U.S. alone have benefited from statins (such drugs as Lipitor, Zocor, Crestor, Pravachol) in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells the fascinating story of statins. Drawn from interviews with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterise major discoveries.

Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesteremic agents --- Enzyme inhibitors --- History. --- Inhibitors --- Anticholesteremic agents. --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Antilipemic agents

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Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Atherosclerosis. --- Anticholesteremic agents. --- Statins (Cardiovascular agents) --- Hydroxymethylglutaryl coenzyme A reductases --- Statin drugs --- Anticholesterol drugs --- Antihypercholestermic agents --- Cholesterol inhibitors --- Cholesterol-lowering drugs --- Hypocholesteremic agents --- Inhibitors --- Anticholesteremic agents --- Enzyme inhibitors --- Antilipemic agents --- Arteriosclerosis --- Atherosclerosis --- Therapeutics --- Hypolipidemic Agents --- Hyperlipidemias --- Sterols --- Cholestenes --- Lipid Regulating Agents --- Membrane Lipids --- Dyslipidemias --- Cholestanes --- Antimetabolites --- Lipids --- Arterial Occlusive Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Steroids --- Chemicals and Drugs --- Molecular Mechanisms of Pharmacological Action --- Vascular Diseases --- Lipid Metabolism Disorders --- Therapeutic Uses --- Metabolic Diseases --- Pharmacologic Actions --- Polycyclic Compounds --- Cardiovascular Diseases --- Chemical Actions and Uses --- Nutritional and Metabolic Diseases --- Diseases --- Cholesterol --- Drug Therapy --- Hypercholesterolemia --- Anticholesteremic Agents --- Atherogenesis --- Atheroscleroses --- Chylomicron Remnants --- Plaque, Atherosclerotic --- Anticholesteremic Drugs --- Anticholesteremics --- Inhibitors, Cholesterol --- Cholesterol Inhibitors --- Hypocholesteremic Agents --- Agents, Anticholesteremic --- Agents, Hypocholesteremic --- Drugs, Anticholesteremic --- Elevated Cholesterol --- High Cholesterol Levels --- Hypercholesteremia --- Cholesterol Level, High --- Cholesterol Levels, High --- Cholesterol, Elevated --- Cholesterols, Elevated --- Elevated Cholesterols --- High Cholesterol Level --- Hypercholesteremias --- Hypercholesterolemias --- Level, High Cholesterol --- Levels, High Cholesterol --- Cholesterol, Dietary --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Epicholesterol --- Nutritional Physiological Phenomena --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Compounds, Polycyclic --- Hydrocarbons, Cyclic --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Diseases, Metabolic --- Thesaurismosis --- Disease, Metabolic --- Metabolic Disease --- Thesaurismoses --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Lipid Metabolism Disorder --- Metabolism Disorder, Lipid --- Metabolism Disorders, Lipid --- Disease, Vascular --- Diseases, Vascular --- Vascular Disease --- Pharmacological Mechanisms of Action --- Catatoxic Steroids --- Steroid --- Steroids, Catatoxic --- Arterial Obstructive Diseases --- Arterial Obstructive Disease --- Arterial Occlusive Disease --- Disease, Arterial Obstructive --- Disease, Arterial Occlusive --- Diseases, Arterial Obstructive --- Diseases, Arterial Occlusive --- Obstructive Disease, Arterial --- Obstructive Diseases, Arterial --- Occlusive Disease, Arterial --- Occlusive Diseases, Arterial --- Lipid --- Antimetabolite --- Dyslipidemia --- Dyslipoproteinemias --- Dyslipoproteinemia --- Cell Membrane Lipid --- Cell Membrane Lipids --- Membrane Lipid --- Lipid, Cell Membrane --- Lipid, Membrane --- Lipids, Cell Membrane --- Lipids, Membrane --- Membrane Lipid, Cell --- Membrane Lipids, Cell --- Cell Membrane --- Membranes --- Lipid Regulating Drugs --- Agents, Lipid Regulating --- Drugs, Lipid Regulating --- Regulating Agents, Lipid --- Regulating Drugs, Lipid --- Sterol --- Antihyperlipemics --- Antihyperlipidemics --- Antilipemic Drugs --- Antilipemics --- Hypolipidemic Drugs --- Antihyperlipidemic --- Antilipemic --- Antilipemic Agents --- Antilipemic Drug --- Hypolipidemic Agent --- Hypolipidemic Drug --- Agent, Hypolipidemic --- Agents, Antilipemic --- Agents, Hypolipidemic --- Drug, Antilipemic --- Drug, Hypolipidemic --- Drugs, Antilipemic --- Drugs, Hypolipidemic --- Arterioscleroses --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Hyperlipidemia --- Lipemia --- Lipidemia --- Hyperlipemia --- Hyperlipemias --- Lipemias --- Lipidemias --- antagonists & inhibitors --- drug therapy --- therapeutic use --- therapy --- Statins (Cardiovascular agents). --- therapeutic use. --- drug therapy. --- etiology. --- adverse effects. --- complications.