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This book presents the cellular, molecular and physical aspects of force and movement by the self-assembly of actin, one of the most abundant proteins found in cells, into cytoskeletal filaments. « Actin-based motile processes » are responsible for a large variety of motile activities such as chemotactic locomotion, embryonic and metastatic cell migration, wound healing, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic activities, as well as morphogenetic processes including, axis patterning in early embryos, axonal growth in brain development, and the immune response and synaptic plasticity processes at the origin of learning and memory. The book describes how the recently undertaken multidisciplinary and multiscale approaches have explored the molecular and physical mechanisms at the origin of force and movement produced by actin self-assembly. The chosen topics show how advances have been made in the field of cell motility due to the progress in live cell imaging, light microscopy, improved resolution in the structure of large protein assemblies, the biochemical analysis and mathematical modeling of actin assembly dynamics and the development of nanotechnologies enabling us to measure forces in the range of pico- to nano-newtons produced by actin assemblies.

Actin. --- Actomyosin. --- Cells -- Motility. --- Cells --- Cytology --- Biology --- Health & Biological Sciences --- Motility --- Cytology. --- Motility. --- Cell biology --- Cellular biology --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Movement --- Medicine. --- Cancer research. --- Biotechnology. --- Cell biology. --- Developmental biology. --- Biomedicine. --- Biomedicine general. --- Cell Biology. --- Developmental Biology. --- Cancer Research. --- Cytologists --- Biomechanics --- Cell physiology --- Oncology. --- Tumors --- Development (Biology) --- Growth --- Ontogeny --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemical engineering --- Genetic engineering --- Health Workforce --- Biomedicine, general. --- Cancer research

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Histology. Cytology --- Cells --- CELL MOVEMENT --- Motility --- Cell Movement. --- 576.322 --- -#WSCH:FYS3 --- Organisms --- Cytology --- Cell Migration --- Locomotion, Cell --- Migration, Cell --- Motility, Cell --- Movement, Cell --- Cell Locomotion --- Cell Motility --- Cell Movements --- Movements, Cell --- Cell Tracking --- Cell motility. Amoeboid movement. Ciliary and flagellary movements --- Motility. --- 576.322 Cell motility. Amoeboid movement. Ciliary and flagellary movements --- Cell movement --- Cellulaire beweging --- Mouvement cellulaire --- Cell Movement --- #WSCH:FYS3 --- Cell motility --- Cellular movement --- Motility of cells --- Biomechanics --- Cell physiology --- Movement --- Cells - Motility. --- Cells - Motility --- CELLS --- MOTILITY --- LIGHT MICROSCOPY --- ACTIN --- MUSCLES --- CONTRACTION --- MICROTUBULES --- CILIA

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This book surveys the most recent advances in physics-inspired cell movement models. This synergetic, cross-disciplinary effort to increase the fidelity of computational algorithms will lead to a better understanding of the complex biomechanics of cell movement, and stimulate progress in research on related active matter systems, from suspensions of bacteria and synthetic swimmers to cell tissues and cytoskeleton.Cell motility and collective motion are among the most important themes in biology and statistical physics of out-of-equilibrium systems, and crucial for morphogenesis, wound healing, and immune response in eukaryotic organisms. It is also relevant for the development of effective treatment strategies for diseases such as cancer, and for the design of bioactive surfaces for cell sorting and manipulation. Substrate-based cell motility is, however, a very complex process as regulatory pathways and physical force generation mechanisms are intertwined. To understand the interplay between adhesion, force generation and motility, an abundance of computational models have been proposed in recent years, from finite element to immerse interface methods and phase field approaches. This book is primarily written for physicists, mathematical biologists and biomedical engineers working in this rapidly expanding field, and can serve as supplementary reading for advanced graduate courses in biophysics and mathematical biology. The e-book incorporates experimental and computer animations illustrating various aspects of cell movement.

Biophysics --- Biology --- Health & Biological Sciences --- Cells --- Motility. --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Movement --- Biomechanics --- Cell physiology --- Biomedical engineering. --- Physiology --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Computer Appl. in Life Sciences. --- Numerical and Computational Physics, Simulation. --- Physiological, Cellular and Medical Topics. --- Data processing. --- Mathematics. --- Animal physiology --- Animals --- Anatomy --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Medicine --- Biophysics. --- Biological physics. --- Bioinformatics . --- Computational biology . --- Physics. --- Biomathematics. --- Mathematics --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Bioinformatics --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Biological physics --- Medical sciences --- Physics --- Data processing

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Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development of effective antagonists. One antagonist, plerixafor, is now clinically approved for stem cell mobilization of lymphoma and myeloma patients. This progress allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoietic cells, i.e. leukemia cells. In preclinical studies, a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. CXCR4 antagonists are an exciting new class of compounds which are also used for the mobilization of angiogenic cells or for the treatment of solid tumors. This book provides concise reviews of novel developments, as well as possible future developments on CXCR4.  .

Hematopoietic stem cells -- Transplantation. --- Stem cells --Transplantation. --- Stem cells --- Hematopoietic stem cells --- Cancer --- Receptors, CXCR --- Stem Cell Transplantation --- Receptors, HIV --- Biological Therapy --- Bone Marrow Cells --- Metabolic Phenomena --- Chemicals and Drugs --- Stem Cells --- Cells --- Hematopoietic System --- Receptors, Chemokine --- Cell Transplantation --- Phenomena and Processes --- Receptors, Virus --- Therapeutics --- Antigens, CD --- Receptors, Cytokine --- Anatomy --- Hemic and Immune Systems --- Receptors, G-Protein-Coupled --- Transplantation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Cell Surface --- Receptors, Immunologic --- Antigens, Differentiation --- Membrane Proteins --- Surgical Procedures, Operative --- Proteins --- Antigens, Surface --- Biological Markers --- Amino Acids, Peptides, and Proteins --- Antigens --- Biological Factors --- Hematopoietic Stem Cells --- Receptors, CXCR4 --- Hematopoietic Stem Cell Mobilization --- Heterocyclic Compounds --- Hematopoietic Stem Cell Transplantation --- Metabolism --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Cytology --- Therapeutic use --- Treatment --- Motility. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Therapy --- Movement --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Biomechanics --- Cell physiology --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect