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Annotation This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most widely used organophosphate insecticides, and has a broad spectrum of applications in agriculture and public health, notably mosquito control. The insecticide parathion has been largely banned or restricted throughout the world due to toxicity to wildlife and humans. Tetrachlorvinphos is banned in the European Union, but continues to be used in the USA and elsewhere as an insecticide on animals, including in pet flea collars. The IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of these agents.
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This volume presents an evaluation of the carcinogenicity of benzene, updating with new data the most recent evaluation provided in Volume 100F of the IARC Monographs. Benzene, a simple aromatic hydrocarbon, occurs naturally and as a result of human activity, notably as a result of combustion, and it is a high-volume chemical now used mostly as a chemical intermediate. Human exposure to benzene is widespread through the air, in consumer products, and in industry. An IARC Monographs Working Group reviewed epidemiological studies, animal cancer bioassays, and mechanistic data to assess the carcinogenicity of benzene and conducted quantitative analyses of data on genotoxicity and human cancer risks.
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This volume presents an evaluation of the carcinogenicity of benzene, updating with new data the most recent evaluation provided in Volume 100F of the IARC Monographs. Benzene, a simple aromatic hydrocarbon, occurs naturally and as a result of human activity, notably as a result of combustion, and it is a high-volume chemical now used mostly as a chemical intermediate. Human exposure to benzene is widespread through the air, in consumer products, and in industry. An IARC Monographs Working Group reviewed epidemiological studies, animal cancer bioassays, and mechanistic data to assess the carcinogenicity of benzene and conducted quantitative analyses of data on genotoxicity and human cancer risks.
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Annotation This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most widely used organophosphate insecticides, and has a broad spectrum of applications in agriculture and public health, notably mosquito control. The insecticide parathion has been largely banned or restricted throughout the world due to toxicity to wildlife and humans. Tetrachlorvinphos is banned in the European Union, but continues to be used in the USA and elsewhere as an insecticide on animals, including in pet flea collars. The IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of these agents.
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Carcinogens --- Pharmacokinetics --- Carcinogens
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