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The Beta-3 Adrenoreceptor plays an important role in regulating human fat storage and variants of this receptor are thought to be relevant to diabetes.In addition to the major interest in obesity and diabetes expressed by the pharmaceutical industry, increasing numbers of academic groups are attracted by this general research area. This renewed interest is of course in part stimulated by available financing from industry. It also reflects the growing realisation that metabolism remains an open frontier: little is known about adipocyte sub-populations, specific markers, or endocrine functio
Beta adrenoceptors. --- Adrenergic beta agonists. --- Adrenergic beta receptor agonists --- Beta adrenergic agonists --- Beta adrenergic receptor agonists --- Beta adrenoceptor agonists --- Beta agonists --- Beta sympathomimetic agents --- Beta sympathomimetics --- Sympathomimetic agents --- Beta adrenoceptors --- Adrenergic beta receptors --- Adrenergic receptors, Beta --- Adrenoceptors, Beta --- Beta adrenergic receptors --- Receptors, Beta adrenergic --- Adrenaline --- Adrenergic beta agonists --- Adrenergic beta blockers --- Receptors
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Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
Lungs --- Adrenergic beta agonists --- Diseases, Obstructive --- Chemotherapy. --- Therapeutic use. --- Adrenergic beta receptor agonists --- Beta adrenergic agonists --- Beta adrenergic receptor agonists --- Beta adrenoceptor agonists --- Beta agonists --- Beta sympathomimetic agents --- Beta sympathomimetics --- Lung --- Medicine. --- Pharmacology. --- Respiratory organs --- Biomedicine. --- Pharmacology/Toxicology. --- Pneumology/Respiratory System. --- Diseases. --- Sympathomimetic agents --- Beta adrenoceptors --- Cardiopulmonary system --- Chest --- Toxicology. --- Pneumology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Respiratory organs—Diseases. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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Adrenergic beta agonists --- Adrenergic beta agonists in animal nutrition --- Livestock --- Physiological effect --- Congresses --- Growth --- Carcasses --- Quality --- Adrénaline --- Epinephrine --- Catécholamine --- Catecholamines --- Élevage intensif --- Intensive husbandry --- Bovin --- Cattle --- Carcasse --- European Union --- -Adrenergic beta agonists in animal nutrition --- -Livestock --- -636.064.6 --- 636.064:591.147 --- 591.134 --- 637.512 --- $?$88/4 --- Animal husbandry --- Farm animals --- Live stock --- Stock (Animals) --- Stock and stock-breeding --- Agriculture --- Animal culture --- Animal industry --- Domestic animals --- Food animals --- Herders --- Range management --- Rangelands --- Animal nutrition --- Medicated feeds --- Adrenergic beta receptor agonists --- Beta adrenergic agonists --- Beta adrenergic receptor agonists --- Beta adrenoceptor agonists --- Beta agonists --- Beta sympathomimetic agents --- Beta sympathomimetics --- Sympathomimetic agents --- Beta adrenoceptors --- -Congresses --- -Quality --- Zoology and Animal Sciences. Animal Nutrition and Feeding --- Zoology and Animal Sciences. Zoology --- Agrotechnology and Food Sciences. Food Sciences --- Feed Additives --- Animal Physiology and Biochemistry --- Animal Nutrition Physiology --- Food Quality and Safety --- Feed Additives. --- Animal Nutrition Physiology. --- Food Quality and Safety. --- 636.064.6 --- Epinephrine. --- Adrenergic beta agonists - Physiological effect - Congresses --- Adrenergic beta agonists in animal nutrition - Congresses --- Livestock - Growth - Congresses --- Livestock - Carcasses - Quality - Congresses --- Bruxelles
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