Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines. Recent examples of advanced nanoparticle-based nanomedicines are COVID-19 RNA vaccines. Regardless of the delivery route of the NPs into the body (intravenous or subcutaneous injection, oral, intranasal, etc.), NPs inevitably come into contact with immune cells, such as macrophages. Macrophages are phagocytizing cells that determine the fate and the lifetime of NPs in relevant biological fluids or tissues, which has consequences for both nanosafety and nanomedicine. The aim of this Special Issue is to cover recent advancements in our understanding of NP–macrophage interactions, with a focus on in vitro models for nanosafety and novel nanomedicine approaches that allow the modulation of the immunological profile of macrophages. The current Special Issue compiles nine papers: seven research articles and two review articles. The original articles include studies on the interaction of different nanomaterials, such as multi-walled carbon nanotubes (MWCNTs), amorphous silica, gold nanoparticles, lipid carriers, and microspheres, with macrophages in different scenarios.

Medicine --- chronic wound --- device --- foot ulcer --- inflammation --- wound healing --- macrophage --- nanomaterial --- nanoparticle --- drug delivery --- immune system --- anti-inflammatory --- innate immunity --- osteoarthritis --- rifabutin --- nanostructured lipid carriers --- cell uptake --- Caco-2 cells --- oral administration --- Crohn’s disease --- nanomaterials --- macrophages --- class A type 1 scavenger receptors --- cytotoxicity --- macrophage–nanoparticle interaction --- monocytes --- gold nanoparticles --- in vitro models --- innate memory --- 2D cultures --- 3D cultures --- carbon nanotube --- scavenger receptor --- phagocytosis --- protein corona --- bovine serum albumin --- synthetic amorphous silica --- in vitro testing --- NR8383 alveolar macrophage --- ICP-MS analysis of cell bound SiO2 --- multi-walled carbon nanotubes --- nanoparticles --- chemokines --- transcriptomics --- zebrafish --- n/a --- Crohn's disease --- macrophage-nanoparticle interaction

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book contributes to increasing the knowledge on the mechanisms of action of natural antioxidants, evidencing their pleiotropic role in the prevention and/or counteraction of degenerative diseases, and promoting their application in the functional food and cosmetic fields.

CNS --- fava beans --- glucose --- fructose --- oxidative stress --- vitagenes --- neurodegeneration --- SH-SY5Y cell line --- 3D cultures --- phytochemicals --- antioxidants --- cyanidin-3-glucoside --- phenolic metabolites --- gut microbiota --- signaling pathways --- intestinal injury --- proliferation --- migration --- vascular smooth muscle cells --- atherosclerosis --- tumor necrosis factor-alpha --- Hibiscus leaf polyphenols --- Rosmarinus officinalis --- essential oil --- scopolamine --- anxiety --- memory --- Ectoine --- keratinocytes --- melanogenesis --- tyrosinase --- α-MSH --- Nrf2 --- bioactive peptides --- Keap1/Nrf2 pathway --- natural antioxidants --- FPP® --- nutraceutical supplementation --- C57BL/6J --- anti-aging effect --- antioxidant effect --- telomeres --- telomerase --- SOD-1 --- GSH --- natural antioxidant --- seaweed --- algae --- Fucus vesiculosus --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

clear cell renal cell carcinoma --- tumor evolution --- tumor ecology --- intratumor heterogeneity --- multisite tumor sampling --- targeted therapy --- uterine carcinosarcoma --- endometrial carcinoma --- metaplastic carcinoma --- epithelial-to-mesenchymal transition --- clonality --- mutation --- TP53 --- PI3K/AKT pathway --- gene expression --- miRNA expression --- tumor microenvironment --- interstitial pH --- acidosis --- tumor heterogeneity --- magnetic resonance imaging --- hyperpolarized 13C MRI --- carbonic anhydrase --- lactic acid --- positron emission tomography --- esophageal squamous cell carcinoma --- precision medicine --- natural killer cells --- tumor mutation burden --- immunotherapy --- PET --- heterogeneity --- radiomics --- radiopharmaceuticals --- SUV --- nuclear medicine --- colon cancer --- Wnt signaling --- phenotypic plasticity --- EMT --- hybrid E/M --- collective and single-cell migration --- beta-catenin paradox --- breast cancer --- immune microenvironment --- DCIS --- ADH --- mammary gland --- cell fate --- 3D cultures --- organoids --- signaling --- single-cell RNAseq --- tumor endothelial cell --- metastasis --- angiocrine factor --- microsatellite instability --- colorectal cancer --- immune checkpoints --- deficient mismatch repair --- plasticity --- biomechanics --- circulating tumor cells (CTCs) --- extracellular vesicles --- metastatic niche --- epigenetics --- CTC-clusters --- single-cell analysis --- cellular heterogeneity --- circulating tumor cells --- pancreatic cancer --- epithelial mesenchymal plasticity --- target discovery --- review --- genomics --- intra-tumour heterogeneity --- subclonal diversity --- treatment resistance

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Viruses exhibit an elegant simplicity as they are so basic, but so frightening. Although only a few are life threatening, they have substantial implications for human health and the economy, as exemplified by the ongoing coronavirus pandemic. Viruses are rather small infectious agents found in all types of life forms, from animals and plants to prokaryotes and archaebacteria. They are obligate intracellular parasites, and as such, subvert many molecular and cellular processes of the host cell to ensure their own replication, amplification, and subsequent spread. This Special Issue addresses the cell biology of viral infections based on a collection of original research articles, communications, opinions, and reviews on various aspects of virus–host cell interactions. Together, these articles not only provide a glance into the latest research on the cell biology of viral infections but also include novel technological developments.

Research & information: general --- Biology, life sciences --- ectoderm --- mesoderm --- human development --- embryogenesis --- interferon response --- interferon-induced genes --- self-organizing map (SOM) data portrayal --- epigenetic signature --- embryoid body --- TGF-β and Wnt/β-catenin pathway --- interferon --- tumor necrosis factor --- STAT --- interferon regulatory factor --- antiviral --- autoimmunity --- inflammation --- hepatitis C virus --- HCV --- erlin-1 --- erlin-2 --- host factor --- endoplasmic reticulum --- RNA replication --- protein production --- virus production --- lipid droplet --- TAP-GFP --- fluorescent TAP platform --- antigen presentation --- MHC I --- immune evasion --- BoHV-1 UL49.5 --- virus --- calcium channels --- calcium pumps --- virus–host interaction --- Ebola virus --- filovirus --- inclusion bodies --- NXF1 --- liquid organelles --- mRNA export --- cancer immunotherapy --- oncolytic virus --- herpes simplex virus --- immune checkpoint inhibitor --- angiogenesis inhibitor --- rabies --- uDISCO --- 3D imaging --- rabies pathogenicity --- astrocyte infection --- metabolism --- apoptosis --- autophagy --- HIV-1 spread --- cell-free infection --- cell–cell transmission --- 3D cultures --- mathematical modeling --- environmental restriction --- CAD --- pyrimidine synthesis --- HEV --- particle production --- viral replication --- virus entry --- hantavirus --- Tula virus --- replication --- factory --- RNA synthesis --- Golgi --- stress granules --- actin cytoskeleton --- nucleocapsid transport --- Arp2/3 complex --- ERAP2 --- ERAP2/Iso3 --- microbial infections --- alternative splicing --- SARS-CoV-2 --- host cell response --- coronavirus --- MERS-CoV --- SARS-CoV --- sialic acid --- Siglec --- antiviral peptide --- enveloped viruses --- membrane phosphatidylserine --- envelope disruption --- membrane damage --- antiviral autophagy --- galectin --- bacterial invasion --- adenovirus --- lysophagy --- ESCRT machinery --- cedar virus --- henipavirus --- fusion protein --- endocytosis --- biological activity --- feline coronavirus --- feline enteric coronavirus --- FECV --- feline infectious peritonitis virus --- FIPV --- feline intestinal organoids --- alphaviruses --- cell death --- mosquito --- tolerance --- ectoderm --- mesoderm --- human development --- embryogenesis --- interferon response --- interferon-induced genes --- self-organizing map (SOM) data portrayal --- epigenetic signature --- embryoid body --- TGF-β and Wnt/β-catenin pathway --- interferon --- tumor necrosis factor --- STAT --- interferon regulatory factor --- antiviral --- autoimmunity --- inflammation --- hepatitis C virus --- HCV --- erlin-1 --- erlin-2 --- host factor --- endoplasmic reticulum --- RNA replication --- protein production --- virus production --- lipid droplet --- TAP-GFP --- fluorescent TAP platform --- antigen presentation --- MHC I --- immune evasion --- BoHV-1 UL49.5 --- virus --- calcium channels --- calcium pumps --- virus–host interaction --- Ebola virus --- filovirus --- inclusion bodies --- NXF1 --- liquid organelles --- mRNA export --- cancer immunotherapy --- oncolytic virus --- herpes simplex virus --- immune checkpoint inhibitor --- angiogenesis inhibitor --- rabies --- uDISCO --- 3D imaging --- rabies pathogenicity --- astrocyte infection --- metabolism --- apoptosis --- autophagy --- HIV-1 spread --- cell-free infection --- cell–cell transmission --- 3D cultures --- mathematical modeling --- environmental restriction --- CAD --- pyrimidine synthesis --- HEV --- particle production --- viral replication --- virus entry --- hantavirus --- Tula virus --- replication --- factory --- RNA synthesis --- Golgi --- stress granules --- actin cytoskeleton --- nucleocapsid transport --- Arp2/3 complex --- ERAP2 --- ERAP2/Iso3 --- microbial infections --- alternative splicing --- SARS-CoV-2 --- host cell response --- coronavirus --- MERS-CoV --- SARS-CoV --- sialic acid --- Siglec --- antiviral peptide --- enveloped viruses --- membrane phosphatidylserine --- envelope disruption --- membrane damage --- antiviral autophagy --- galectin --- bacterial invasion --- adenovirus --- lysophagy --- ESCRT machinery --- cedar virus --- henipavirus --- fusion protein --- endocytosis --- biological activity --- feline coronavirus --- feline enteric coronavirus --- FECV --- feline infectious peritonitis virus --- FIPV --- feline intestinal organoids --- alphaviruses --- cell death --- mosquito --- tolerance

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Viruses exhibit an elegant simplicity as they are so basic, but so frightening. Although only a few are life threatening, they have substantial implications for human health and the economy, as exemplified by the ongoing coronavirus pandemic. Viruses are rather small infectious agents found in all types of life forms, from animals and plants to prokaryotes and archaebacteria. They are obligate intracellular parasites, and as such, subvert many molecular and cellular processes of the host cell to ensure their own replication, amplification, and subsequent spread. This Special Issue addresses the cell biology of viral infections based on a collection of original research articles, communications, opinions, and reviews on various aspects of virus–host cell interactions. Together, these articles not only provide a glance into the latest research on the cell biology of viral infections but also include novel technological developments.

Research & information: general --- Biology, life sciences --- ectoderm --- mesoderm --- human development --- embryogenesis --- interferon response --- interferon-induced genes --- self-organizing map (SOM) data portrayal --- epigenetic signature --- embryoid body --- TGF-β and Wnt/β-catenin pathway --- interferon --- tumor necrosis factor --- STAT --- interferon regulatory factor --- antiviral --- autoimmunity --- inflammation --- hepatitis C virus --- HCV --- erlin-1 --- erlin-2 --- host factor --- endoplasmic reticulum --- RNA replication --- protein production --- virus production --- lipid droplet --- TAP-GFP --- fluorescent TAP platform --- antigen presentation --- MHC I --- immune evasion --- BoHV-1 UL49.5 --- virus --- calcium channels --- calcium pumps --- virus–host interaction --- Ebola virus --- filovirus --- inclusion bodies --- NXF1 --- liquid organelles --- mRNA export --- cancer immunotherapy --- oncolytic virus --- herpes simplex virus --- immune checkpoint inhibitor --- angiogenesis inhibitor --- rabies --- uDISCO --- 3D imaging --- rabies pathogenicity --- astrocyte infection --- metabolism --- apoptosis --- autophagy --- HIV-1 spread --- cell-free infection --- cell–cell transmission --- 3D cultures --- mathematical modeling --- environmental restriction --- CAD --- pyrimidine synthesis --- HEV --- particle production --- viral replication --- virus entry --- hantavirus --- Tula virus --- replication --- factory --- RNA synthesis --- Golgi --- stress granules --- actin cytoskeleton --- nucleocapsid transport --- Arp2/3 complex --- ERAP2 --- ERAP2/Iso3 --- microbial infections --- alternative splicing --- SARS-CoV-2 --- host cell response --- coronavirus --- MERS-CoV --- SARS-CoV --- sialic acid --- Siglec --- antiviral peptide --- enveloped viruses --- membrane phosphatidylserine --- envelope disruption --- membrane damage --- antiviral autophagy --- galectin --- bacterial invasion --- adenovirus --- lysophagy --- ESCRT machinery --- cedar virus --- henipavirus --- fusion protein --- endocytosis --- biological activity --- feline coronavirus --- feline enteric coronavirus --- FECV --- feline infectious peritonitis virus --- FIPV --- feline intestinal organoids --- alphaviruses --- cell death --- mosquito --- tolerance