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From birth to first calving, the replacement heifer undergoes tremendous changes anatomically as well as in feeding and management practices. The calf changes from being a pseudo-monogastric to a full ruminant within a period of two months. During the same period, the calf is fed colostrum, milk, or milk replacer, and starter with or without hay. Notably, the lifetime milk production and health of a dairy cow is highly dependent on early life nutrition and management of the calf and, subsequently, the heifer. Hence, animal scientists continue to investigate critical areas such as colostrum feeding, the level of liquid feeding, gut microbial succession, energy and protein levels, housing, health management, and their interactions with the animal in an effort to help dairy producers raise successful and sustainable dairy enterprises.

betaine --- dairy cows --- newborn calves --- fat mobilization --- immunity --- calf --- glutamine --- autophagy --- apoptosis --- calf economics --- replacement --- ADG --- cost per kg --- calves --- rumen --- epithelium --- microbiota --- diet --- feed additives --- feeding management --- dairy calf --- involuntary culling --- mortality --- replacement heifer --- survival rate --- amino acid pattern --- Holstein heifers --- lysine --- methionine --- threonine --- heat stress --- yak calf --- early weaning --- caecal microbiota --- 16S rRNA gene sequencing --- growth performance --- heifer --- bull --- Simmental --- fattening --- management --- carcass and meat quality --- weaning age --- Holstein calves --- growth --- milk replacer --- metabolism --- development --- body condition score --- peripartum --- primiparous dairy cow --- pair housing --- individual housing --- behavior --- dairy calf feeding --- health --- welfare --- nutrition --- stakeholder attitudes --- forage --- performance --- rumen fermentation

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Cyanobacteria are a group of ubiquitous photosynthetic prokaryotes. Their occurrence has been increasing worldwide, due to anthropogenic activities and climate change. Several cyanobacterial species are able to synthesize a high number of bioactive molecules, among them, cyanotoxins (microcystins, cylindrospermopsin, nodularin, etc.), which are considered a health concern. For risk assessment of cyanotoxins, more scientific knowledge is required to perform adequate hazard characterization, exposure evaluation and, finally, risk characterization of these toxins. This Special Issue “Cyanobacteria and Cyanotoxins: New Advances and Future Challenges” presents new research or review articles related to different aspects of cyanobacteria and cyanotoxins, and contributes to providing new toxicological data and methods for a more realistic risk assessment.

method validation --- sirtuin 1 (SIRT1) --- arctic --- Cylindrospermopsin --- Microcystin-LR --- 16S rRNA gene --- astaxanthin --- secondary metabolites --- shotgun metagenomic sequencing --- time-resolved fluoroimmunoassay --- Histopathological evaluation --- cyanobacterial thresholds --- akinetes --- nutrient enrichment --- benthic mats --- cylindrospermopsin --- drinking water treatment plant --- blue-green algae supplements --- lettuce --- genotoxicity --- exposure --- bacterial community --- PCR --- microcystin-LR --- marine natural compounds --- ELISA --- [d-Leu1]Microcystin-LR --- Paracentrotus lividus --- tadpoles --- apoptosis --- 16S rRNA gene sequencing --- PSP toxins --- marine cyanobacteria --- hemolytic essay --- energy budget --- bioassays --- anatoxin-a --- Lithobates catesbeianus --- mixture --- reproductive toxicity --- cyanobacteria --- taste-and-odor compounds --- Procambarus clarkii --- drinking water --- saxitoxin --- resveratrol --- harmful algal blooms --- cytotoxicity --- phylogenetic analyses --- Yangtze estuary --- microcystin --- mutagenicity --- detection --- Artemia salina --- water source --- cyanotoxins --- microcystins --- in vitro --- marine sponges --- microcystin-LR (MC-LR) --- UPLC-MS/MS --- reservoir --- microbial metabolisms --- Aphanizomenon flos-aquae --- monoclonal antibody --- oxidative stress --- Nostocales