Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.

Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Agents teratògens. --- Embriologia --- Manuals de laboratori --- Tècniques de laboratori --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Factors teratògens --- Medicaments teratògens --- Teratògens

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Stem cells. --- Veterinary embryology. --- Embryology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cèl·lules mare embrionàries --- Embriologia --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Cèl·lules mare

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the importance of consuming vitamins throughout human history, but empirical studies of their physiological role and mode of action only began about 150 years ago. Since then, the biochemical nature of vitamin A and its active derivative, retinoic acid, have been identified and researchers around the globe have investigated retinoic acid’s physiological function in growth processes and in maintaining life Written by leading experts, this book discusses the latest findings and advances in retinoic acid research. It addresses topics such as the role of retinoic acid signaling in a multitude of processes, including limb, heart and respiratory system development, as well as its role in maintaining postnatal organ systems. This book is a valuable resource for scientists involved in vitamin A/retinoic acid research and readers interested in developmental biology.

Human physiology. --- Nutrition   . --- Embryology. --- Physiology. --- Human Physiology. --- Nutrition. --- Animal physiology --- Animals --- Biology --- Anatomy --- Animal embryology --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Alimentation --- Food --- Nutrition --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Human biology --- Medical sciences --- Human body --- Embryology --- Development --- Health aspects --- Cellular signal transduction. --- Retinoids. --- Vitamin A analogs --- Vitamin A congeners --- Vitamin A derivatives --- Carotenoids --- Diterpenes --- Interphotoreceptor retinoid-binding protein --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Retinoides --- Vitamina A --- Embriologia --- Fisiologia humana --- Biologia humana --- Ciències de la salut --- Fisiologia --- Mecànica humana --- Reproducció humana --- Cos humà --- Desenvolupament embriològic --- Desenvolupament embrional --- Embriogènesi --- Embriogènia --- Embriologia animal --- Biologia --- Evolució --- Morfologia animal --- Edat gestacional --- Epigènesi --- Cèl·lules germinals --- Cordó umbilical --- Diferenciació sexual --- Fetus --- Gametogènesi --- Genètica del desenvolupament --- Miogènesi --- Neurobiologia del desenvolupament --- Òvuls --- Placenta --- Teratologia --- Biologia del desenvolupament --- Cèl·lules --- Protoplasma --- Reproducció --- Retinol --- Vitamina antixeroftàlmica --- Vitamines liposolubles --- Carotenoides