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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the 42nd issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, consists of five revised selected regular papers, presenting the following topics: Privacy-Preserving Top-k Query Processing in Distributed Systems; Trust Factors and Insider Threats in Permissioned Distributed Ledgers: An Analytical Study and Evaluation of Popular DLT Frameworks; Polystore and Tensor Data Model for Logical Data Independence and Impedance Mismatch in Big Data Analytics; A General Framework for Multiple Choice Question Answering Based on Mutual Information and Reinforced Co-occurrence; Rejig: A Scalable Online Algorithm for Cache Server Configuration Changes.

Data mining. --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Computer communication systems. --- Computer system failures. --- Computer security. --- Operating systems (Computers). --- Logic design. --- Computers. --- Computer Communication Networks. --- System Performance and Evaluation. --- Systems and Data Security. --- Operating Systems. --- Logic Design. --- Information Systems and Communication Service. --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic brains --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Machine theory --- Calculators --- Cyberspace --- Design, Logic --- Design of logic systems --- Digital electronics --- Electronic circuit design --- Logic circuits --- Switching theory --- Computer operating systems --- Computers --- Disk operating systems --- Systems software --- Computer privacy --- Computer system security --- Cyber security --- Cybersecurity --- Electronic digital computers --- Protection of computer systems --- Security of computer systems --- Data protection --- Security systems --- Hacking --- Computer failures --- Computer malfunctions --- Failure of computer systems --- System failures (Engineering) --- Fault-tolerant computing --- Communication systems, Computer --- Computer communication systems --- Data networks, Computer --- ECNs (Electronic communication networks) --- Electronic communication networks --- Networks, Computer --- Teleprocessing networks --- Data transmission systems --- Digital communications --- Electronic systems --- Information networks --- Telecommunication --- Cyberinfrastructure --- Electronic data processing --- Network computers --- Operating systems --- Protection --- Security measures --- Failures --- Distributed processing --- Computer networks. --- Data protection. --- Data and Information Security. --- Evaluation. --- Data governance --- Data regulation --- Personal data protection --- Protection, Data

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Operational research. Game theory --- Molecular biology --- Biology --- Programming --- Information systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- IR (information retrieval) --- stochastische analyse --- bio-informatica --- biologie --- informatica --- database management --- informatietechnologie --- KI (kunstmatige intelligentie) --- robots --- moleculaire biologie --- AI (artificiële intelligentie)

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This book constitutes the refereed proceedings of the 7th International Conference on Database and Expert Systems Applications, DEXA '96, held in Zurich, Switzerland, in September 1996. The 77 revised full papers included were selected from a total of nearly 200 submissions. They report on a broad spectrum of advanced applications and the design of database and expert systems. Among the topics addressed are object-oriented databases, active databases, temporal databases, transactions and concurrency, relational databases, CSCW and workflow systems, parallel and distributed systems, expert systems, knowledge-based systems, and information retrieval.

Database management --- Expert systems (Computer science) --- Congresses. --- Congresses --- Data structures (Computer scienc. --- Artificial intelligence. --- Information theory. --- Database management. --- Information storage and retrieval systems. --- Data Structures and Information Theory. --- Artificial Intelligence. --- Theory of Computation. --- Database Management. --- Information Systems Applications (incl. Internet). --- Information Storage and Retrieval. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- Electronic data processing --- Communication theory --- Communication --- Cybernetics --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Database management - Congresses --- Expert systems (Computer science) - Congresses.

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This volume contains the papers which were selected for oral presentation at the first Bioinformatics Research and Development (BIRD) conference held in Berlin, Germany during March 12-14, 2007. BIRD covers a wide range of topics related to bioinformatics like microarray data, genomics, single nucleotide polymorphism, sequence analysis, systems biology, medical applications, proteomics, information systems. The conference was very competitive. From about 140 submissions only 36 were selected by the Program Committee for oral presentation at BIRD and for publication in these proceedings. The acceptance rate was 1/4. The decisions of the Program Committee were guided by the recommendations of several reviewers for each paper. It should be mentioned that these proceedings have companion proceedings published by the Austrian Computer Society where selected poster presentations of the BIRD conference are included. The invited talk titled "From Flies to Human Disease" by Josef Penninger, one of the leading researcher in genetic experiments for investigating disease pathogenesis, was very inspiring and gave new insights into future bioinformatics challenges.

Bioinformatics --- Biological systems --- Computational biology --- Proteomics --- Bio-informatique --- Protéomique --- Congresses. --- Research --- Data processing --- Congrès --- Congresses --- Publication Formats --- Genetics --- Biology --- Investigative Techniques --- Sequence Analysis --- Biochemistry --- Methods --- Computational Biology --- Genomics --- Sequence Analysis, DNA --- Biological Science Disciplines --- Genetic Techniques --- Publication Characteristics --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Disciplines and Occupations --- Biology - General --- Health & Biological Sciences --- Biosystems --- Systems, Biological --- Bio-informatics --- Biological informatics --- Life sciences. --- Mathematical statistics. --- Data mining. --- Information storage and retrieval. --- Artificial intelligence. --- Bioinformatics. --- Life Sciences. --- Life Sciences, general. --- Computational Biology/Bioinformatics. --- Data Mining and Knowledge Discovery. --- Artificial Intelligence (incl. Robotics). --- Information Storage and Retrieval. --- Probability and Statistics in Computer Science. --- Information science --- Systems biology --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Mathematics --- Statistical inference --- Statistics, Mathematical --- Statistics --- Probabilities --- Sampling (Statistics) --- Biosciences --- Sciences, Life --- Science --- Statistical methods --- Molecular biology --- Proteins --- System theory --- Philosophy --- Information storage and retrieva. --- Computer science. --- Artificial Intelligence. --- Informatics --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Computer science—Mathematics. --- Computational and Systems Biology. --- Data centers

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The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind applicational development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolvement of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between Grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the inaugural issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, consists of journal versions of talks invited to the DEXA 2009 conference and further invited contributions by well-known scientists in the field. Therefore, the content of this issue covers a wide range of different topics in the area of the title of this new journal.

Transaction systems (Computer systems) --- Database management --- Expert systems (Computer science) --- Peer-to-peer architecture (Computer networks) --- Computer Science --- Engineering & Applied Sciences --- Database management. --- P2P (Computer network architecture) --- Knowledge-based systems (Computer science) --- Systems, Expert (Computer science) --- Data base management --- Data services (Database management) --- Database management services --- DBMS (Computer science) --- Generalized data management systems --- Services, Database management --- Systems, Database management --- Systems, Generalized database management --- TP systems (Computer systems) --- Transaction-oriented systems (Computer systems) --- Transaction processing systems (Computer systems) --- Computer science. --- Computer communication systems. --- Computers. --- Data mining. --- Information storage and retrieval. --- Computer Science. --- Computer Communication Networks. --- Database Management. --- Data Mining and Knowledge Discovery. --- Information Storage and Retrieval. --- Information Systems Applications (incl. Internet). --- Information Systems and Communication Service. --- Electronic data processing --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- Automatic computers --- Automatic data processors --- Computer hardware --- Computing machines (Computers) --- Electronic brains --- Electronic calculating-machines --- Electronic computers --- Hardware, Computer --- Computer systems --- Cybernetics --- Machine theory --- Calculators --- Cyberspace --- Communication systems, Computer --- Computer communication systems --- Data networks, Computer --- ECNs (Electronic communication networks) --- Electronic communication networks --- Networks, Computer --- Teleprocessing networks --- Data transmission systems --- Digital communications --- Electronic systems --- Information networks --- Telecommunication --- Cyberinfrastructure --- Network computers --- Informatics --- Science --- Distributed processing --- Computer network architectures --- Real-time data processing --- Artificial intelligence --- Soft computing --- Information storage and retrieva. --- Information systems. --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Application software. --- Application computer programs --- Application computer software --- Applications software --- Apps (Computer software) --- Computer software