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Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis.

Drug development. --- Pyrimidines. --- Heterocyclic compounds --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Development --- Heterocyclic chemistry. --- Heterocyclic compounds. --- Pyrimidines --- Heterocyclic Compounds, Fused-Ring --- Drug Discovery --- Organic Chemistry Phenomena --- Chemistry, Pharmaceutical --- Structure-Activity Relationship --- Research. --- chemistry --- chemical synthesis --- methods

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Venture Capital is a form of financing provided by wealthy investors, investment banks and other financial institutions to start-ups and small- to medium-sized enterprises with strong growth potential in exchange of private equity stakes. These investors are also known as venture capitalists. With the rise of start-ups and small ventures, the market of venture capitalist and the interest of people in venture capitalism are also increasing. The valuation of the firms done by the venture capitalist at the beginning is not just a betting game. It is a thorough research done using different strategies and computing formulas. Venture Capital Investments gives a fundamental understanding of various aspects of venture capital covering the nature of investments, deal evaluation, structure, economics and fundraising. It discusses the challenges a venture capitalist faces right from raising funds to evaluating a potential deal and exit valuation. The book begins by covering the difference between the private market and the public market. Finally, it discusses fund economics and fund structure in venture capital firms. The book will be a helpful read for entrepreneurs who want to get into the shoes of a venture capitalist and understand how they valuate a firm or a start-up. It will also be an informative read for the aspiring venture capitalists who are interested to enter the venture capital market.

Venture capital. --- Capital investments. --- Capital expenditures --- Capital improvements --- Capital spending --- Fixed asset expenditures --- Plant and equipment investments --- Plant investments --- Investments --- Risk capital --- Seed capital --- Capital --- Small business --- Small business investment companies --- Finance

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Pineal gland. --- Melatonin. --- Pineal gland --- Epiphysis cerebri --- Pineal body --- Endocrine glands --- Acetylmethoxytryptamine --- Methoxyindolylethylacetamide --- Hormones --- Tryptamine --- Diseases. --- Secretions

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This succinct volume addresses the production of inactive, potentially toxic proteins in the absence of correct protein folding and the resultant neurodegenerative diseases. Other topics include intrinsic disorder in protein structure and function and the effects of molten globules on protein toxicity. This concise and yet thorough text also discusses using toxin structure as a model for studying structural and functional aspects of protein chemistry. Protein Toxins in Modeling Biochemistry, a SpringerBrief, is essential reading for advanced researchers, scientists and advanced graduate students interested in protein chemistry and related areas of biochemistry and molecular science. .

Life sciences. --- Microbiology. --- Proteomics. --- Proteins. --- Life Sciences. --- Protein Science. --- Protein Structure. --- Protein-Ligand Interactions. --- Applied Microbiology. --- Cytology. --- Biochemistry. --- Microbial biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Cell biology --- Cellular biology --- Composition --- Biology --- Microorganisms --- Chemistry --- Medical sciences --- Cells --- Cytologists --- RNA-ligand interactions. --- Molecular biology --- Proteins --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics