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Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Drug targeting. --- Protein-protein interactions. --- Interactions, Protein-protein --- Protein interactions --- Molecular association --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Targeting --- Dosage forms --- Toxicology. --- Cytology. --- Biochemistry. --- Medicine. --- Pharmacology/Toxicology. --- Cell Biology. --- Medical Biochemistry. --- Molecular Medicine. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Toxicology --- Composition --- Health Workforce --- Pharmacology. --- Cell biology. --- Medical biochemistry. --- Molecular biology. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Physiological effect

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Histology. Cytology --- Molecular biology --- Human biochemistry --- Pharmacology. Therapy --- Pathological biochemistry --- farmacologie --- biochemie --- toxicologie --- cytologie --- histologie --- moleculaire biologie

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The cyclic nucleotides 3',5'-adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) play important roles in the control of cardiovascular function under physiological and pathological conditions. In this book, which is a reprint of a Special Issue of the Journal of Cardiovascular Development and Disease entitled "Cyclic Nucleotide Signaling and the Cardiovascular System", internationally recognized experts give an overview of this vibrant scientific field. The first series of articles deal with the localization and function of membrane-bound and soluble adenylate cyclases, followed by articles on the roles of phosphodiesterase isoforms in the heart. Cyclic nucleotide signaling takes place in nanodomains and the A-kinase anchor proteins (AKAPS) are essential for the compartmentalized assembly of signaling proteins into functional complexes. Reviews on the role of AKAP proteins in the physiology and pathophysiology of the heart are also included in this book. Cyclic nucleotides act through effector proteins and articles on EPAC and POPDC proteins inform the reader of recent developments on these topics. A major advancement in our understanding of cyclic nucleotide signaling came through the use of genetically encoded cAMP sensor molecules, and a series of articles review the current insight that these reporter molecules have provided. The final set of articles in this book deals with the association of the cyclic nucleotide pathway and cardiovascular disease as well as the development of novel therapeutic approaches.

Nucleotides.