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Serous (peritoneal, pleural and pericardial) effusions are a frequently encountered clinical finding in everyday medical practice and one of the most common specimen types submitted for cytological evaluation. The correct diagnosis of effusions is critical for patient management, as well as for prognostication and yet many clinicians find diagnosis and treatment of cancer cells in effusions very challenging. Featuring multiple microscopic illustrations of all diagnostic entities and ancillary techniques (immunhistochemistry and molecular methods), this book provides a comprehensive, authoritative guide to all aspects of serous effusions, including etiology, morphology and ancillary diagnostic methods, as well as data related to therapeutic approaches and prognostication. Section One covers diagnosis for benign and malignant effusions including the etiological reasons for the accumulation of effusions that provides the reader with the full spectrum of differential diagnoses at this anatomic site. Section Two discusses biology, therapy and prognosis highlighting clinical approaches that may be of value to patients and the movement towards personalized medicine and targeted therapy. Written by experts in the field internationally, Serous Effusions will provide an indispensable guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.

Cancer -- Cytopathology. --- Cancer --- Pleural Diseases --- Diseases --- Heart Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Body Fluids --- Medicine --- Respiratory Tract Diseases --- Cardiovascular Diseases --- Health Occupations --- Fluids and Secretions --- Disciplines and Occupations --- Anatomy --- Pericardial Effusion --- Pathology --- Diagnosis --- Neoplasms --- Ascitic Fluid --- Pleural Effusion --- Health & Biological Sciences --- Oncology --- Cytopathology --- Serous fluids. --- Membranes (Biology) --- Serosal fluids --- Biological membranes --- Biomembranes --- Medicine. --- Internal medicine. --- Oncology. --- Medical biochemistry. --- Pathology. --- Medicine & Public Health. --- Internal Medicine. --- Medical Biochemistry. --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Tumors --- Medicine, Internal --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Biological interfaces --- Protoplasm --- Lymph --- Oncology  . --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition

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Human biochemistry --- Oncology. Neoplasms --- Pathological biochemistry --- Pathology --- Human medicine --- pathologie --- biochemie --- geneeskunde --- oncologie

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Serous (peritoneal, pleural and pericardial) effusions are a frequently encountered clinical finding in everyday medical practice and one of the most common specimen types submitted for cytological evaluation. The correct diagnosis of effusions is critical for patient management, as well as for prognostication and yet many clinicians find diagnosis and treatment of cancer cells in effusions very challenging. Featuring multiple microscopic illustrations of all diagnostic entities and ancillary techniques (immunhistochemistry and molecular methods), this book provides a comprehensive, authoritative guide to all aspects of serous effusions, including etiology, morphology and ancillary diagnostic methods, as well as data related to therapeutic approaches and prognostication. Section One covers diagnosis for benign and malignant effusions including the etiological reasons for the accumulation of effusions that provides the reader with the full spectrum of differential diagnoses at this anatomic site. Section Two discusses biology, therapy and prognosis highlighting clinical approaches that may be of value to patients and the movement towards personalized medicine and targeted therapy. Written by experts in the field internationally, Serous Effusions will provide an indispensible guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.

Human biochemistry --- Oncology. Neoplasms --- Pathological biochemistry --- Pathology --- Human medicine --- pathologie --- biochemie --- geneeskunde --- oncologie

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This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions.

Ovaries --- Neoplasms. --- Oncology. --- Cancer --- Research. --- 3D-cell culture --- Ovarian cancer stem cells --- ovarian cancer --- tumor-associated macrophage --- BRCA --- chemoresistance --- fallopian tube --- tumour microenvironment --- mouse models of ovarian cancer --- patient derived xenografts --- primary ovarian tumour cells --- Ascites

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Basic Sciences. Meteorology --- Meteorology (General).