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Pharmaceutical chemistry --- Drugs --- Drug interactions --- Metabolism --- Pharmacosynthesis. Pharmacochemistry --- Chimie pharmaceutique --- Interaction --- Drug interactions. --- Chemistry, Pharmaceutical. --- Pharmaceutical chemistry. --- Pharmacology --- Metabolism. --- Textbooks & monographs 1891-2000. --- Médicaments --- Métabolisme --- Drugs - Metabolism

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Pharmacology. --- Drugs --- Pharmacologie --- Médicaments --- Metabolism. --- Métabolisme --- Pharmacology --- Metabolism --- PHARMACOLOGY --- 615 --- Drug metabolism --- Pharmacokinetics --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Farmacologie. Farmaceutische wetenschappen --- Physiological effect --- Textbooks & monographs 1891-2000 --- Textbooks & monographs 1891-2000. --- Médicaments --- Métabolisme --- Drugs - Metabolism

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Drugs --- Pharmacokinetics --- Pharmaceutical Preparations --- PHARMACOLOGY --- Metabolism --- metabolism --- Pharmacology. --- -Pharmacokinetics --- #Lilly --- Drug kinetics --- Kinetics, Drugs --- Chemical kinetics --- Pharmacology --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Pharmacologies --- metabolism. --- Kinetics --- pharmacology --- Pharmacokinetics. --- Metabolism. --- Drug metabolism --- Drugs - Metabolism --- Pharmaceutical Preparations - metabolism

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The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

Biological techniques --- Enzymology --- Toxicology --- Enzymes --- Drugs --- Metabolic conjugation --- Metabolism --- Metabolic detoxification --- -Enzymes --- -#Lilly --- 577.15 --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Conjugation, Metabolic --- Conjugation (Metabolism) --- Biotransformation (Metabolism) --- Bioconjugates --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymes. Catalysts of biological reactions. Enzymology --- Enzymes. --- Metabolic conjugation. --- Metabolic detoxication, Drug. --- Metabolic detoxification. --- Metabolism. --- 577.15 Enzymes. Catalysts of biological reactions. Enzymology --- #Lilly --- Drug metabolism --- Pharmacokinetics --- Metabolic detoxication --- Drugs - Metabolism --- Drugs - Metabolic detoxification

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In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Pharmacokinetics --- Drugs --- Physiological effect --- Metabolism --- Medicine. --- Pharmacy. --- Pharmacology. --- Biochemistry. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Pharmaceutical Preparations --- Drug Interactions --- Pharmacology --- metabolism --- Toxicology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Medicine --- Materia medica --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Pharmacy --- Composition --- Drug kinetics --- Kinetics, Drugs --- Chemical kinetics --- Kinetics --- Pharmacokinetics - Handbooks, manuals, etc. --- Drugs - Physiological effect - Handbooks, manuals, etc. --- Drugs - Metabolism - Handbooks, manuals, etc. --- Pharmaceutical Preparations - metabolism - handbooks --- Pharmacokinetics - handbooks --- Drug Interactions - Handbooks. --- Pharmacology - Handbooks.