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The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
Proteolytic enzymes. --- Proteinase. --- Brain --- Brain chemistry. --- Pathophysiology. --- Peptide hydrolases --- Proteases --- Hydrolases --- Cerebrum --- Mind --- Central nervous system --- Head --- Proteolytic enzymes --- Neurochemistry --- Analysis and chemistry --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition
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Erythrocytes --- Blood --- -Body fluids --- Fear of blood --- Red blood cells --- Red blood corpuscles --- Red cells --- Blood cells --- Analysis --- -Analysis --- Analysis of blood --- Blood chemistry --- Blood tests --- Clinical chemistry --- Analysis and chemistry --- Chemistry
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Blood Tests Made Easy is a quick reference guide designed to bring medical students up to speed when interpreting blood tests on their clinical placements. Small enough to be carried and quickly referenced on the go, this book covers everything you need to know when interpreting bloods, including the main abnormalities you are likely to encounter. Rather than focusing on theory or physiology, it is designed to provide an easy-to-follow guide to support clinical decision making.This latest addition to the Made Easy series will fill knowledge gaps on blood test interpretation, becoming a valuable asset both for medical students and, later, as a reference guide to increase junior doctors' confidence on the wards.Relevant to real life - material laid out like real hospital laboratory testsEasy to use - information presented in a clear and accessible formatCase studies and multiple-choice questions to aid revisionPortable for easy access on the wards
Blood --- Analysis of blood --- Blood chemistry --- Blood tests --- Clinical chemistry --- Examination of the blood --- Diagnosis, Laboratory --- Examination --- Analysis --- Analysis and chemistry --- Chemistry --- Semiology --- Diseases --- Diagnosis --- Hematology --- Diagnosis. --- Hematologic Tests. --- Diagnostic Techniques and Procedures. --- Technique. --- bloed --- bloedtesten --- Examination. --- Analysis.
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In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes. Proteases in the Brain reviews the role and regulation of proteases in Alzheimer’s disease brain ischemia and traumatic brain injury human glioma inflammatory and infectious diseases of the central nervous system metabolism of the prion protein modulating synaptic activity multiple sclerosis neuronal plasticity and memory consolidation Parkinson’s disease processing, conversion and inactivation of neuropeptides. Proteases in the Brain is a timely and useful source of information both for those well versed in the role of proteases in the brain and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction.
Brain --- Proteinase. --- Brain chemistry. --- Pathophysiology. --- Neurochemistry --- Proteolytic enzymes --- Cerebrum --- Mind --- Central nervous system --- Head --- Analysis and chemistry --- Biochemistry. --- Neurosciences. --- Biochemistry, general. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition
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The main message of this monograph is that the appearance of the mammalian brain with the ability to acquire drives ensured the development of social life, and eventually led to the evolution of the human society. This most sophisticated form of organized life on earth is still in the trial and error phase of its development. It seeks to outgrow the myth-directed era of its history and come to its final state, the ration-directed human society.
Neurochemistry. --- Brain chemistry. --- Brain --- Neurochemistry --- Biochemistry --- Neurosciences --- Analysis and chemistry --- Neurosciences. --- Animal behavior. --- Psychology, clinical. --- Psychopharmacology. --- Behavioral Sciences. --- Neuropsychology. --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Animals --- Animals, Habits and behavior of --- Behavior, Animal --- Ethology --- Animal psychology --- Zoology --- Ethologists --- Psychology, Comparative --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Psychotropic effects --- Behavior --- Behavioral sciences. --- Neurophysiology --- Psychophysiology
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Brain chemistry --- Brain --- Developmental neurobiology --- Infant psychology --- Infants --- Parent and child --- Child and parent --- Children and parents --- Parent-child relations --- Parents and children --- Children and adults --- Interpersonal relations --- Parental alienation syndrome --- Sandwich generation --- Infant development --- Child development --- Child psychology --- Developmental neurology --- Neurogenesis --- Developmental biology --- Embryology --- Neurobiology --- Nervous system --- Neuroplasticity --- Neurochemistry --- Growth --- Development --- Psychology --- Evolution --- Analysis and chemistry
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On-chip pretreatment of whole blood is one of the hottest topics in lab-on-a-chip research since whole blood has been regarded as the most important clinical sample. This e-book is a valuable reference for readers interested in this specific clinical application of advanced MEMS technology.
Microelectromechanical systems. --- Microfluidic devices. --- Blood --- Analysis of blood --- Blood chemistry --- Blood tests --- Clinical chemistry --- Fluidic devices --- Microtechnology --- MEMS (Microelectromechanical systems) --- Micro-electro-mechanical systems --- Micro-machinery --- Microelectromechanical devices --- Micromachinery --- Micromachines --- Micromechanical devices --- Micromechanical systems --- Electromechanical devices --- Mechatronics --- Analysis. --- Analysis and chemistry --- Chemistry
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The book will present the progress made since the last meeting in fall 2013 concerning the analysis of circulating extra-cellular nucleic acids. There are a modest number of laboratories involved in this field, nevertheless the number of papers published by researchers is extensive. The articles which will be published in this meeting report will be a valuable contribution for researchers and research students alike and will help them to stay on top of the developments in different research areas and to „cross borders“ between them.
Nucleic acids --- Blood --- Metabolism. --- Analysis. --- Analysis of blood --- Blood chemistry --- Blood tests --- Polynucleotides --- Analysis and chemistry --- Chemistry --- Medicine. --- Cancer research. --- Microarrays. --- Molecular biology. --- Oncology. --- Bioinformatics. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Tumors --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Data processing --- Clinical chemistry --- DNA microarrays. --- Oncology . --- DNA biochips --- Microarrays, DNA --- Biochips --- Immobilized nucleic acids --- Health Workforce
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Molecular biology --- Human biochemistry --- Neuropathology --- Brain chemistry --- Neuropeptides --- Brain --- Peptides --- 577.112.6 --- 577.175.8 --- 591.481.1 --- Brain peptides --- Nerve tissue proteins --- Neurotransmitters --- Neurochemistry --- 591.481.1 Brain of vertebrates. Encephalon. Cerebellum --- Brain of vertebrates. Encephalon. Cerebellum --- 577.175.8 Hormone-like substances (hormonoids). Neurotransmitters. Histamine --- Hormone-like substances (hormonoids). Neurotransmitters. Histamine --- 577.112.6 Synthetic peptides and polypeptides --- Synthetic peptides and polypeptides --- physiology --- Analysis and chemistry
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Brain --- Cerveau --- Congresses. --- Congrès --- Neurotransmitter Agents. --- Brain Chemistry. --- Neurons. --- -Brain Chemistry --- -Neurons --- -Neurotransmitters --- -Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Nerve cells --- Neurocytes --- Cells --- Nervous system --- Cerebrum --- Mind --- Central nervous system --- Head --- Nerve Cells --- Cell, Nerve --- Cells, Nerve --- Nerve Cell --- Neuron --- Chemistry, Brain --- Brain Chemistries --- Chemistries, Brain --- Chemistry --- Nerve Transmitter Substances --- Neurohormones --- Neuromodulator --- Neuromodulators --- Neuroregulator --- Neurosteroids --- Neurotransmitter --- Neurotransmitters --- Substances, Nerve Transmitter --- Transmitter Substances, Nerve --- Neurotoxins --- Congresses --- congresses --- Analysis and chemistry --- chemistry --- Brain chemistry --- Neurons --- -Congresses --- Congrès --- Brain Chemistry --- Neurotransmitter Agents --- Neurotransmitter Agent --- Nerve Transmitter Substance --- Neurohormone --- Neurohumor --- Substance, Nerve Transmitter --- Transmitter Substance, Nerve