TY - BOOK ID - 8581132 TI - Extracellular matrix degradation AU - Parks, William C. AU - Mecham, Robert P. PY - 2011 SN - 3642168604 3642168612 PB - New York : Springer, DB - UniCat KW - Collagen. KW - Connective Tissue. KW - Connective tissues -- Congresses. KW - Extracellular matrix. KW - Polysaccharides. KW - Extracellular Space KW - Metalloendopeptidases KW - Membrane Glycoproteins KW - Antigens, Surface KW - Proteins KW - Amino Acids, Peptides, and Proteins KW - Cellular Structures KW - Endopeptidases KW - Glycoproteins KW - Membrane Proteins KW - Antigens KW - Metalloproteases KW - Peptide Hydrolases KW - Biological Factors KW - Cells KW - Chemicals and Drugs KW - Hydrolases KW - Anatomy KW - Enzymes KW - Enzymes and Coenzymes KW - Cell Adhesion Molecules KW - Extracellular Matrix KW - Matrix Metalloproteinases KW - Tissue Inhibitor of Metalloproteinases KW - Biology KW - Human Anatomy & Physiology KW - Health & Biological Sciences KW - Cytology KW - Physiology KW - Cement substance (Anatomy) KW - Ground substance (Anatomy) KW - Ground substance (Histology) KW - Intercellular matrix KW - Interstitial substance KW - Matrix, Extracellular KW - Life sciences. KW - Molecular biology. KW - Biochemistry. KW - Proteins. KW - Cell biology. KW - Life Sciences. KW - Cell Biology. KW - Biochemistry, general. KW - Protein Science. KW - Molecular Medicine. KW - Connective tissues KW - Extracellular space KW - Cytology. KW - Medicine. KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Chemistry KW - Cell biology KW - Cellular biology KW - Cytologists KW - Composition KW - Health Workforce KW - Proteins . KW - Molecular biochemistry KW - Molecular biophysics KW - Biochemistry KW - Biophysics KW - Biomolecules KW - Systems biology KW - Proteids KW - Polypeptides KW - Proteomics UR - https://www.unicat.be/uniCat?func=search&query=sysid:8581132 AB - Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology. ER -