TY - BOOK ID - 8580464 TI - Cancer Biology and the Nuclear Envelope : Recent Advances May Elucidate Past Paradoxes AU - Schirmer, Eric C. AU - de las Heras, Jose I. PY - 2014 SN - 1489980318 1489980326 PB - New York, NY : Springer New York : Imprint: Springer, DB - UniCat KW - Biology. KW - Cancer. KW - Medical Oncology -- periodicals. KW - Neoplasms -- periodicals. KW - Cancer cells KW - Nuclear membranes KW - Diseases KW - Biological Science Disciplines KW - Cell Membrane Structures KW - Proteins KW - Nuclear Matrix-Associated Proteins KW - Metabolic Phenomena KW - Cell Physiological Phenomena KW - Amino Acids, Peptides, and Proteins KW - Nuclear Proteins KW - Cell Membrane KW - Phenomena and Processes KW - Natural Science Disciplines KW - Disciplines and Occupations KW - Chemicals and Drugs KW - Cellular Structures KW - Cells KW - Anatomy KW - Physiology KW - Lamins KW - Organelle Shape KW - Metabolism KW - Neoplasms KW - Membrane Proteins KW - Nuclear Envelope KW - Medicine KW - Health & Biological Sciences KW - Oncology KW - Cancer cells. KW - Nuclear membranes. KW - Nuclear envelope KW - Medicine. KW - Cancer research. KW - Medical microbiology. KW - Proteins. KW - Cell membranes. KW - Biomedicine. KW - Cancer Research. KW - Medical Microbiology. KW - Protein Science. KW - Membrane Biology. KW - Biomedicine general. KW - Cell surfaces KW - Cytoplasmic membranes KW - Plasma membranes KW - Plasmalemma KW - Membranes (Biology) KW - Glycocalyces KW - Proteids KW - Biomolecules KW - Polypeptides KW - Proteomics KW - Cancer research KW - Clinical sciences KW - Medical profession KW - Human biology KW - Life sciences KW - Medical sciences KW - Pathology KW - Physicians KW - Cell membranes KW - Cell nuclei KW - Pathology, Cellular KW - Oncology. KW - Microbiology. KW - Biochemistry. KW - Biological chemistry KW - Chemical composition of organisms KW - Organisms KW - Physiological chemistry KW - Biology KW - Chemistry KW - Microbial biology KW - Microorganisms KW - Tumors KW - Composition KW - Proteins . KW - Cell membranes . KW - Biomedicine, general. KW - Health Workforce UR - https://www.unicat.be/uniCat?func=search&query=sysid:8580464 AB - "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.". ER -